{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T21:49:16Z","timestamp":1792446556333,"version":"4.5.0"},"reference-count":62,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T00:00:00Z","timestamp":1761782400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Geriatr Psychiatry Neurol"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Mild Behavioral Impairment (MBI) has been increasingly recognized as a potential early clinical marker of neurodegenerative disease, while blood-based biomarkers such as phosphorylated tau 217 (p-tau217) and neurofilament light chain (NfL) are associated with Alzheimer\u2019s disease and axonal damage, respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate the role of MBI and blood-based biomarkers of neurodegeneration in the early detection of dementia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Fifty-one individuals without dementia aged 60 or older with mood or anxiety disorders underwent psychiatric, neuropsychiatric, and cognitive evaluations, as well as assessment of plasma p-tau217 and NfL at baseline and at one-year follow-up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A higher proportion of males was observed in the MBI group compared to the non-MBI group (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.076). MBI was significantly associated with a higher risk of conversion to dementia (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.006). MBI patients showed a trend toward higher baseline p-tau217 (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.096) and significantly higher NfL at follow-up (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.025), suggesting active neurodegeneration. Individuals who converted to dementia had marginally higher baseline p-tau217 (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.053) and NfL (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.091).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>MBI and blood-based biomarkers of neurodegeneration appear to be promising clinical tools for identifying dementia risk in its early stages.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/08919887251394747","type":"journal-article","created":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T22:58:01Z","timestamp":1761865081000},"page":"413-425","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Mild Behavioral Impairment and Plasma Biomarkers of Neurodegeneration as Predictors of Cognitive Decline in Geriatric Patients With Psychiatric Disorders"],"prefix":"10.1177","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3865-7975","authenticated-orcid":false,"given":"Camilla","family":"Elefante","sequence":"first","affiliation":[{"name":"University of Pisa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Francesca","family":"Beatino","sequence":"additional","affiliation":[{"name":"University of Pisa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Fustini","sequence":"additional","affiliation":[{"name":"University of Pisa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vittoria","family":"Lepri","sequence":"additional","affiliation":[{"name":"University of Pisa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donatella","family":"Acierno","sequence":"additional","affiliation":[{"name":"University of 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