{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T06:44:46Z","timestamp":1782974686928,"version":"3.54.5"},"reference-count":57,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2025,12,24]],"date-time":"2025-12-24T00:00:00Z","timestamp":1766534400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,12,24]],"date-time":"2025-12-24T00:00:00Z","timestamp":1766534400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100015303","name":"Otsuka Pharmaceutical Development and Commercialization","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100015303","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013327","name":"H. Lundbeck A\/S","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013327","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Geriatr Psychiatry Neurol"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Agitation is a neuropsychiatric symptom commonly observed in Alzheimer\u2019s dementia, which causes substantial burden for patients and caregivers. In this exploratory analysis, Neuropsychiatric Inventory (NPI) data were pooled from two randomized, double-blind, fixed-dose, placebo-controlled trials of brexpiprazole in agitation associated with dementia due to Alzheimer\u2019s disease. The analysis explored the efficacy of brexpiprazole on agitation and other neuropsychiatric symptoms, including their impact on caregivers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Major Findings<\/jats:title>\n                    <jats:p>\n                      Brexpiprazole 2 or 3\u00a0mg\/day (\n                      <jats:italic toggle=\"yes\">N<\/jats:italic>\n                      = 368) showed greater improvement vs placebo (\n                      <jats:italic toggle=\"yes\">N<\/jats:italic>\n                      = 253) from baseline in NPI agitation\/aggression domain score (Week 6 onwards), and in the associated occupational disruptiveness\/caregiver distress score (Week 4 onwards). Improvements with brexpiprazole vs placebo also occurred on other NPI and occupational disruptiveness\/caregiver distress scores, including irritability\/lability, aberrant motor behavior, and anxiety.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Over 12\u00a0weeks, brexpiprazole was associated with greater improvements vs placebo in agitation\/aggression and other neuropsychiatric symptoms, and in associated caregiver disruption\/distress. ClinicalTrials.gov identifiers: NCT01862640; NCT03548584.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/08919887251407124","type":"journal-article","created":{"date-parts":[[2025,12,24]],"date-time":"2025-12-24T11:20:56Z","timestamp":1766575256000},"page":"589-601","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Efficacy of Brexpiprazole on Neuropsychiatric Symptoms and Impact on Caregivers: Pooled Neuropsychiatric Inventory (NPI) Analysis in Patients With Agitation Associated With Dementia due to Alzheimer\u2019s Disease"],"prefix":"10.1177","volume":"39","author":[{"given":"George T","family":"Grossberg","sequence":"first","affiliation":[{"name":"Saint Louis University School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marwan N","family":"Sabbagh","sequence":"additional","affiliation":[{"name":"Department of Neurology, Barrow Neurological Institute"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5882-0920","authenticated-orcid":false,"given":"Sanjeda R","family":"Chumki","sequence":"additional","affiliation":[{"name":"Medical Affairs, Otsuka Pharmaceutical Development & Commercialization Inc"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Wang","sequence":"additional","affiliation":[{"name":"Medical Affairs, Lundbeck LLC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro","family":"Such","sequence":"additional","affiliation":[{"name":"Medical Affairs, H. 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