{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T20:26:37Z","timestamp":1786739197287,"version":"build-2736575974"},"reference-count":47,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T00:00:00Z","timestamp":1786492800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Geriatr Psychiatry Neurol"],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Mild Cognitive Impairment (MCI) and Mild Behavioral Impairment (MBI) can be prodromal stages of neurodegenerative disease associated with plasma biomarkers of tau pathology and neuroaxonal damage. However, in psychiatric populations, the relationship between MCI, MBI and these plasma biomarkers remains unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study examined the association of MCI with plasma biomarkers of neurodegeneration (phosphorylated tau217 [p-tau217] and neurofilament light chain [NfL]), metabolic alterations, psychiatric disorder features, and MBI in older adults receiving psychiatric treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Fifty-one non-demented patients \u226560\u00a0years, referred for mood or anxiety disorders, were enrolled and classified based on cognitive performance as MCI (n = 20) or non-MCI (n = 31). Assessments included psychiatric, cognitive, functional, and plasma biomarker measures.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      MCI patients exhibited higher p-tau217 (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .003) and NfL (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .042) levels, lower cognitive scores (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; .001), and a trend toward reduced functioning (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .074). MCI was also associated with later onset of psychiatric symptoms (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .033) and greater prevalence of MBI (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; .001). Logistic regression identified plasma NfL as a marker of MCI (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; .05) in this sample.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our findings suggest that integrating cognitive, psychiatric, and biomarker assessments may improve early detection of dementia risk.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/08919887261477071","type":"journal-article","created":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T03:37:53Z","timestamp":1786592273000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Plasma Biomarkers and Clinical Indicators for Identifying Mild Cognitive Impairment in Older Adults With Psychiatric Disorders"],"prefix":"10.1177","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3865-7975","authenticated-orcid":false,"given":"Camilla","family":"Elefante","sequence":"first","affiliation":[{"name":"Independent Researcher"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Francesca","family":"Beatino","sequence":"additional","affiliation":[{"name":"Azienda USL Toscana Nord Ovest"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Marro","sequence":"additional","affiliation":[{"name":"University of Pisa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Coccoglioniti","sequence":"additional","affiliation":[{"name":"University of Pisa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cosimo","family":"Lazzerini","sequence":"additional","affiliation":[{"name":"University of Pisa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Pacini","sequence":"additional","affiliation":[{"name":"University of Pisa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ani","family":"Gasparyan","sequence":"additional","affiliation":[{"name":"Universidad Miguel Hern\u00e1ndez"},{"name":"Instituto de Investigaci\u00f3n Sanitaria y Biom\u00e9dica de Alicante, ISABIAL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esther","family":"Caparr\u00f3s","sequence":"additional","affiliation":[{"name":"Universidad Miguel Hern\u00e1ndez"},{"name":"Instituto de Investigaci\u00f3n Sanitaria y Biom\u00e9dica de Alicante, ISABIAL"},{"name":"Instituto de Salud Carlos III"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucia","family":"Petrozzi","sequence":"additional","affiliation":[{"name":"University of Pisa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriele","family":"Siciliano","sequence":"additional","affiliation":[{"name":"University of Pisa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5529-3731","authenticated-orcid":false,"given":"Zahinoor","family":"Ismail","sequence":"additional","affiliation":[{"name":"University of Calgary"},{"name":"University of Exeter"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenzo","family":"Lattanzi","sequence":"additional","affiliation":[{"name":"University of Pisa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filippo","family":"Baldacci","sequence":"additional","affiliation":[{"name":"University of Pisa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Ceravolo","sequence":"additional","affiliation":[{"name":"University of Pisa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5556-1858","authenticated-orcid":false,"given":"Giulio","family":"Perugi","sequence":"additional","affiliation":[{"name":"University of Pisa"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,8,12]]},"reference":[{"key":"e_1_3_5_2_2","unstructured":"World Health Organization. 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