{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T16:24:50Z","timestamp":1791908690370,"version":"4.3.4"},"reference-count":53,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T00:00:00Z","timestamp":1790121600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T00:00:00Z","timestamp":1790121600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["527734"],"award-info":[{"award-number":["527734"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Geriatr Psychiatry Neurol"],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Cognitive reserve (CR) buffers against cognitive manifestations of neurodegenerative disease; little is known about CR and neuropsychiatric symptoms (NPS). We investigated CR moderation on the relationship between AD-related cortical changes and NPS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Cross-sectional data from 455 participants in COMPASS-ND were analyzed. CR score (CRS) was operationalized from education, occupation, and mentally stimulating activities; NPS were assessed using the Mild Behavioral Impairment Checklist. Logistic regression modelled the relationship between hippocampal volume\/entorhinal thickness and NPS. A volume\/thickness*CRS interaction term was included to assess effect modification. All models adjusted for age, sex, and cognition.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      CR moderated the relationship between hippocampal volume and NPS (B = \u22123.39, 95% CI: [\u22126.04, \u22120.84],\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .01), with greater impact at lower CR. A weaker but non-significant interaction effect was observed with lower entorhinal thickness.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Greater CR may mitigate NPS associated with lower hippocampal volume, independent of cognition, suggesting CR may preserve cognition and behaviour.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/08919887261491948","type":"journal-article","created":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T02:24:57Z","timestamp":1790216697000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Can Cognitive Reserve Moderate the Association Between Brain Structure and Later-Life Behavioural Symptoms?"],"prefix":"10.1177","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-3477-7624","authenticated-orcid":false,"given":"Gurshaan","family":"Sidhu","sequence":"first","affiliation":[{"name":"University of Calgary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dylan X.","family":"Guan","sequence":"additional","affiliation":[{"name":"University of Calgary"},{"name":"University of Calgary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryam","family":"Ghahremani","sequence":"additional","affiliation":[{"name":"University of Calgary"},{"name":"University of Calgary"},{"name":"University of Calgary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric E.","family":"Smith","sequence":"additional","affiliation":[{"name":"University of Calgary"},{"name":"University of Calgary"},{"name":"University of Calgary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5529-3731","authenticated-orcid":false,"given":"Zahinoor","family":"Ismail","sequence":"additional","affiliation":[{"name":"University of Calgary"},{"name":"University of Calgary"},{"name":"University of Calgary"},{"name":"University of Calgary"},{"name":"University of Calgary"},{"name":"University of Calgary"},{"name":"University of Calgary"},{"name":"University of 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