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Two previous studies reported contradictory results in patients with dementia of Alzheimer's type treated with 3 g\/day of thiamine. In the present study, we examined the effects of 3 to 8 g\/day thiamine administered orally. Our results suggest that thiamine at these pharmacologic dosages may have a mild beneficial effect in dementia of Alzheimer's type. The mechanism of the observed effect is unknown, but the findings warrant further investigation, not only for their therapeutic implications but for their possible etiologic clues. In addition, the results suggest long-term carry-over effects that should be considered in the design of future studies.<\/jats:p>","DOI":"10.1177\/089198879300600408","type":"journal-article","created":{"date-parts":[[2014,3,18]],"date-time":"2014-03-18T19:53:09Z","timestamp":1395172389000},"page":"222-229","source":"Crossref","is-referenced-by-count":66,"title":["Preliminary Findings of High-Dose Thiamine in Dementia of Alzheimer's Type"],"prefix":"10.1177","volume":"6","author":[{"given":"Kimford","family":"Meador","sequence":"first","affiliation":[{"name":"Department of Neurology, Medical College of Georgia, Augusta, GA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Loring","sequence":"additional","affiliation":[{"name":"Department of Neurology, Medical College of Georgia, Augusta, GA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martha","family":"Nichols","sequence":"additional","affiliation":[{"name":"Department of Neurology, Medical College of Georgia, Augusta, GA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward","family":"Zamrini","sequence":"additional","affiliation":[{"name":"Department of Neurology, Medical College of Georgia, Augusta, GA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Rivner","sequence":"additional","affiliation":[{"name":"Department of Neurology, Medical College of Georgia, Augusta, GA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hernan","family":"Posas","sequence":"additional","affiliation":[{"name":"Department of Neurology, Medical College of Georgia, Augusta, GA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elaine","family":"Thompson","sequence":"additional","affiliation":[{"name":"Department of Neurology, Medical College of Georgia, Augusta, GA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eugene","family":"Moore","sequence":"additional","affiliation":[{"name":"Department of Neurology, Medical College of Georgia, Augusta, GA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[1993,10,1]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1988.00520320019008"},{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1982.tb31213.x"},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1971.tb00001.x"},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1038\/264186a0"},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1980.tb08999.x"},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.490130310"},{"key":"atypb7","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/S0022-3565(25)32570-X","volume":"217","author":"Barclay LL","year":"1981","journal-title":"J Pharmacol Exp Ther"},{"key":"atypb8","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/112.10.1906"},{"key":"atypb9","doi-asserted-by":"publisher","DOI":"10.3177\/jnsv.29.217"},{"key":"atypb10","doi-asserted-by":"publisher","DOI":"10.1016\/0091-3057(85)90555-6"},{"key":"atypb11","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1988.00520320022009"},{"key":"atypb12","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1988.00520320027010"},{"key":"atypb13","doi-asserted-by":"publisher","DOI":"10.1007\/BF00997071"},{"key":"atypb14","first-page":"726","volume":"1","author":"H\u00e9roux M","year":"1991","journal-title":"Soc Neurosci Abstr"},{"key":"atypb15","doi-asserted-by":"publisher","DOI":"10.1126\/science.7058341"},{"key":"atypb16","doi-asserted-by":"publisher","DOI":"10.1007\/BF00697388"},{"key":"atypb17","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-70094-1_32"},{"key":"atypb18","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1991.00530130093025"},{"key":"atypb19","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.141.11.1356"},{"key":"atypb20","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3956(75)90026-6"},{"key":"atypb21","doi-asserted-by":"crossref","unstructured":"21. 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