{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T09:25:28Z","timestamp":1790673928513,"version":"4.1.0"},"reference-count":22,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[1995,10,1]],"date-time":"1995-10-01T00:00:00Z","timestamp":812505600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Geriatr Psychiatry Neurol"],"published-print":{"date-parts":[[1995,10]]},"abstract":"<jats:p>This study addresses the tolerability of divalproex sodium in elderly psychiatric inpatients with various Axis I diagnoses, using structured assessments. A chart review for a 7-month period on a geropsychiatry inpatient unit identified 13 patients who had been treated with divalproex sodium. All 13 patients received standardized ratings on the Cohen-Mansfield Agitation Inventory (CMAI), Brief Psychiatric Rating Scale (BPRS), Rating Scale for Side Effects (RSSE), and Mini-Mental State Examination (MMSE) on admission and discharge, which were compared using paired f-tests for 12 of the 13 patients. The thirteenth patient was withdrawn from valproate prior to discharge after developing a delirium thought to be secondary to a divalproex-phenytoin interaction. All of the remaining 12 patients tolerated divalproex sodium well with no significant change in MMSE scores ( P = .486), CMAI scores ( P = .0546), or RSSE scores ( P = .124). The change in BPRS score was found to be significant ( P = .004). Based on the present study and previously reported case series, divalproex sodium appears to be well tolerated in an elderly psychiatric population.<\/jats:p>","DOI":"10.1177\/089198879500800407","type":"journal-article","created":{"date-parts":[[2014,3,18]],"date-time":"2014-03-18T19:53:09Z","timestamp":1395172389000},"page":"234-237","source":"Crossref","is-referenced-by-count":34,"title":["Tolerability of Divalproex Sodium in Elderly Psychiatric Patients with Mixed Diagnoses"],"prefix":"10.1177","volume":"8","author":[{"given":"Lucy J.","family":"Puryear","sequence":"first","affiliation":[{"name":"Department of Psychiatry, Veterans Affairs Medical Center, Baylor College of Medicine, Houston, Texas."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark E.","family":"Kunik","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Veterans Affairs Medical Center, Baylor College of Medicine, Houston, 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