{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T07:28:08Z","timestamp":1787124488072,"version":"build-2736575974"},"reference-count":22,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T00:00:00Z","timestamp":1770768000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Endourology"],"published-print":{"date-parts":[[2026,5,1]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>\n                      Holmium laser enucleation of the prostate (HoLEP) is a size-independent treatment for benign prostatic hyperplasia (BPH) that has emerged as the gold standard. Pulse-modulated energy delivery, MOSES\u2122 laser technology, optimizes the delivery of energy by reducing energy loss between the laser fiber and tissue. This study aims to compare the operative parameters of HoLEP using MOSES\u2122 1.0\n                      <jats:italic toggle=\"yes\">vs<\/jats:italic>\n                      2.0.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>We prospectively enlisted patients undergoing HoLEP at two sites in a single institution. Patients were assigned to MOSES\u2122 1.0 or 2.0 by site and remained blinded to laser settings. Primary outcomes were differences in postoperative hemoglobin and enucleation, morcellation and hemostasis times. Secondary outcomes were improvement in International Prostate Symptom Score, maximum urinary flow rate, proportion of prostate enucleated and enucleation efficiency.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Among 236 patients (median age 73 (46\u201390), 67 (28%) were assigned to the 1.0 group and 169 (72%) to the 2.0 group. Baseline demographics were similar, except higher rates of active anticoagulation in the 2.0 cohort (0\n                      <jats:italic toggle=\"yes\">vs<\/jats:italic>\n                      8%,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      &lt; 0.03). The 2.0 group had significantly higher hemoglobin on postoperative day 1 (POD1) (1.0: 12.5\n                      <jats:italic toggle=\"yes\">vs<\/jats:italic>\n                      2.0: 13.0,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      &lt; 0.05). Enucleation (51.0\n                      <jats:italic toggle=\"yes\">vs<\/jats:italic>\n                      46.5 minutes) and morcellation (6.0\n                      <jats:italic toggle=\"yes\">vs<\/jats:italic>\n                      7.0) were comparable. Hemostasis was 33% faster with the 2.0 (15.0\n                      <jats:italic toggle=\"yes\">vs<\/jats:italic>\n                      10.0 minutes,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      &lt; 0.001), even when adjusted for prostate volume (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      &lt; 0.0001) and anticoagulation status (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = 0.001). Although not statistically different, the 1.0 cohort had higher rate of urinary tract infection (11.9%\n                      <jats:italic toggle=\"yes\">vs<\/jats:italic>\n                      6.0%), while the 2.0 cohort had more Clavien-Dindo IV complications (0%\n                      <jats:italic toggle=\"yes\">vs<\/jats:italic>\n                      1.2%) and clot retention (0%\n                      <jats:italic toggle=\"yes\">vs<\/jats:italic>\n                      1.2%).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Compared with the 1.0, the MOSES\u2122 2.0 laser demonstrated significantly improved intraoperative hemostasis while maintaining comparable enucleation efficiency. Although POD1 hemoglobin values were higher with the 2.0 system, the difference was small and unlikely clinically meaningful. Secondary postoperative outcomes were also similar between groups. Our findings suggest that the primary advantage of the updated technology lies in enhanced hemostatic performance rather than procedural efficiency.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/08927790261422980","type":"journal-article","created":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T05:15:43Z","timestamp":1770873343000},"page":"570-578","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Comparative Outcomes of MOSES\n                    <b>\u2122<\/b>\n                    1.0 Versus 2.0 in Holmium Laser Enucleation of the Prostate Is There Really a Difference?"],"prefix":"10.1177","volume":"40","author":[{"given":"Rita R.","family":"Palanjian","sequence":"first","affiliation":[{"name":"Department of Urology, University of Arizona-Tucson, Tucson, Arizona, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taylor","family":"Veschio","sequence":"additional","affiliation":[{"name":"Tucson Campus, University of Arizona School of Medicine, Tucson, Arizona, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ava A.","family":"Delu","sequence":"additional","affiliation":[{"name":"Department of Urology, University of Arizona-Tucson, Tucson, Arizona, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunchin","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Urology, University of Arizona-Tucson, Tucson, Arizona, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David T.","family":"Tzou","sequence":"additional","affiliation":[{"name":"Department of Urology, University of Arizona-Tucson, Tucson, Arizona, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joel T.","family":"Funk","sequence":"additional","affiliation":[{"name":"Department of Urology, University of Alabama Birmingham, Birmingham, Alabama, USA."},{"name":"Department of Urology, Formerly University of Arizona-Tucson, Birmingham, Alabama, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,2,11]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/J.JURO.2008.03.141"},{"key":"e_1_3_2_3_2","first-page":"S3","article-title":"Benign prostatic hyperplasia: An overview","volume":"7","author":"Roehrborn CG","year":"2005","unstructured":"Roehrborn CG. Benign prostatic hyperplasia: An overview. Rev Urol, 2005; 7(Suppl 9):S3\u2013S14. https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC1477638\/ [June 10, 2025]","journal-title":"Rev Urol"},{"issue":"2","key":"e_1_3_2_4_2","first-page":"6","article-title":"HoLEP: The new gold standard for surgical treatment of benign prostatic hyperplasia","volume":"28","author":"Shvero A","year":"2021","unstructured":"Shvero A, , Calio B, , Humphreys MR, , Das AK. HoLEP: The new gold standard for surgical treatment of benign prostatic hyperplasia. Can J Urol, 2021; 28(S2):6\u201310.","journal-title":"Can J Urol"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/JU.0000000000000280"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/J.EURURO.2007.04.074"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/JU.0000000000001693"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1089\/END.2020.0996"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/J.EUF.2022.01.013"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1148\/RADIOL.2501080290"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/J.UROLOGY.2019.11.029"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/BJU.15265"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/J.EUROS.2022.07.012"},{"key":"e_1_3_2_14_2","doi-asserted-by":"crossref","unstructured":"Leeuwen TG Jansen ED Motamedi M Welch AJ Borst CMD. Bubble formation during pulsed laser ablation: Mechanism and implications. Publ by Society of Photo-Optical Instrumentation Engineers. Preprint posted online 1993. 13\u201322. Available from: https:\/\/researchexperts.utmb.edu\/en\/publications\/bubble-formation-during-pulsed-laser-ablation-mechanism-and-impli [June 10 2025].","DOI":"10.1117\/12.147658"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/S00345-024-05277-7\/METRICS"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1177\/03000605231190763"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/J.UROLOGY.2024.08.050"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1089\/END.2024.0054"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)56333-8"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1371\/JOURNAL.PONE.0207208"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1093\/BJA\/AEI279"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1182\/BLOOD-2007-07-102665"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1177\/15579883221113203"}],"container-title":["Journal of Endourology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/08927790261422980","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/08927790261422980","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/08927790261422980","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T07:12:07Z","timestamp":1787123527000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/08927790261422980"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,11]]},"references-count":22,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,5,1]]}},"alternative-id":["10.1177\/08927790261422980"],"URL":"https:\/\/doi.org\/10.1177\/08927790261422980","relation":{},"ISSN":["0892-7790","1557-900X"],"issn-type":[{"value":"0892-7790","type":"print"},{"value":"1557-900X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,11]]}}}