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The diagnostic accuracy of each modality was assessed through sensitivity, specificity, and the area under the curve (AUC) to compare performance in detecting clinically significant prostate cancer (Gleason score\u2009\u2265\u20097).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>MpMRI demonstrated the highest diagnostic performance, with a sensitivity of 90%, specificity of 85%, and AUC of 0.92, outperforming both TRUS (sensitivity 76%, specificity 78%, AUC 0.77) and PET\/CT (sensitivity 82%, specificity 80%, AUC 0.81). MpMRI detected clinically significant tumors in 80% of cases. Although TRUS and PET\/CT had similar detection rates for significant tumors, their overall accuracy was lower. Minor adverse events occurred in 5% of patients undergoing TRUS, while no significant complications were associated with mpMRI or PET\/CT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>These findings suggest that mpMRI is the most reliable imaging modality for early detection of clinically significant prostate cancer. It reduces the need for unnecessary biopsies and optimizes patient management.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/08953996241304988","type":"journal-article","created":{"date-parts":[[2025,2,12]],"date-time":"2025-02-12T05:46:56Z","timestamp":1739339216000},"page":"436-447","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Ultrasound and advanced imaging techniques in prostate cancer diagnosis: A comparative study of mpMRI, TRUS, and PET\/CT"],"prefix":"10.1177","volume":"33","author":[{"given":"Ying","family":"Dong","sequence":"first","affiliation":[{"name":"Department of Radiology, Beijing Renhe Hospital, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Imaging Diagnostic, Binzhou Hospital of Traditional Chinese Medicine, Binzhou City, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Geng","sequence":"additional","affiliation":[{"name":"Department of Oncology, Binzhou Hospital of Traditional Chinese Medicine, Binzhou City, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yankun","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Medical Imaging Center, Central Hospital Afffliated to Shandong First Medical University, Jinan City, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enguo","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Medical Imaging Center, Central Hospital Afffliated to Shandong First Medical University, Jinan City, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,2,12]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.semnuclmed.2016.07.002"},{"key":"e_1_3_2_3_2","first-page":"14","article-title":"Re: focal ablation targeted to the index lesion in multifocal localised prostate cancer: a prospective development study","volume":"196","author":"Taneja SS","unstructured":"Taneja SS. 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