{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T13:24:18Z","timestamp":1790861058866,"version":"4.1.0"},"reference-count":16,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2000,12,1]],"date-time":"2000-12-01T00:00:00Z","timestamp":975628800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Adv Dent Res."],"published-print":{"date-parts":[[2000,12]]},"abstract":"<jats:p>Pleomorphic adenoma, or mixed tumor of the salivary glands, is a benign tumor originating from the major and minor salivary glands. Eighty-five percent of these tumors are found in the parotid gland, 10% in the minor (sublingual) salivary glands, and 5% in the submandibular gland. It is the most common type of salivary gland tumor, accounting for almost 50% of all neoplasms in these organs. In fact, after the first observation of recurrent loss of chromosome 22 in meningioma, this was the second type of benign tumor for which non-random chromosomal changes were reported. The rate of malignant change with the potential to metastasize has been reported to be only 2 to 3%, and only a few cases of metastasizing pleomorphic salivary gland adenomas have been described to date. The fact that these tumors arise in organs located in an ontogenetic transitional zone, a region where endoderm and ectoderm meet, might be one of the reasons for the often-problematic histopathological classification. This type of benign tumor has been cytogenetically very well-characterized, with several hundreds of tumors karyotyped. In addition to the cytogenetic subgroup with an apparently normal diploid stemline (making up approximately 30% of the cases), three major cytogenetic subgroups can be distinguished. In addition to a subgroup showing non-recurrent clonal abnormalities, another subgroup is composed of tumors with various translocations involving 12ql5. By far the largest cytogenetic subgroup, however, consists of tumors with chromosome 8 abnormalities, mainly showing translocations involving region 8ql2. The most frequently encountered aberration in this group is a t(3;8)(p21;q12).<\/jats:p>","DOI":"10.1177\/08959374000140011301","type":"journal-article","created":{"date-parts":[[2009,1,8]],"date-time":"2009-01-08T19:41:28Z","timestamp":1231443688000},"page":"81-83","source":"Crossref","is-referenced-by-count":28,"title":["First Insights into the Molecular Basis of Pleomorphic Adenomas of the Salivary Glands"],"prefix":"10.1177","volume":"14","author":[{"given":"M.L.","family":"Voz","sequence":"first","affiliation":[{"name":"Laboratory for Molecular Oncology, Center for Human Genetics, University of Leuven & Flanders Interuniversity Institute for Biotechnology, Herestraat 49, 3000 Leuven, Belgium, correspondence author,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W.J.M.","family":"Van de Ven","sequence":"additional","affiliation":[{"name":"Laboratory for Molecular Oncology, Center for Human Genetics, University of Leuven & Flanders Interuniversity Institute for Biotechnology, Herestraat 49, 3000 Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Kas","sequence":"additional","affiliation":[{"name":"Laboratory for Molecular Oncology, Center for Human Genetics, University of Leuven & Flanders Interuniversity Institute for Biotechnology, Herestraat 49, 3000 Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2000,12,1]]},"reference":[{"key":"atypb1","first-page":"918","volume":"59","author":"Astrom AK","year":"1999","journal-title":"Cancer Res"},{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/26.1.353"},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.91.23.11168"},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1991.tb07833.x"},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.1006\/geno.1993.1441"},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(90)90690-G"},{"key":"atypb7","doi-asserted-by":"publisher","DOI":"10.1038\/ng0297-170"},{"key":"atypb8","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.36.23026"},{"key":"atypb9","doi-asserted-by":"publisher","DOI":"10.1038\/ng0993-66"},{"key":"atypb10","doi-asserted-by":"publisher","DOI":"10.1006\/geno.1994.1493"},{"key":"atypb11","doi-asserted-by":"publisher","DOI":"10.1006\/geno.1996.0136"},{"key":"atypb12","doi-asserted-by":"publisher","DOI":"10.1016\/0378-1119(94)90767-6"},{"key":"atypb13","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-2264(199611)17:3<166::AID-GCC4>3.0.CO;2-2"},{"key":"atypb14","doi-asserted-by":"publisher","DOI":"10.1677\/joe.0.1490367"},{"key":"atypb15","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1201660"},{"key":"atypb16","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-437X(98)80068-3"}],"container-title":["Advances in Dental Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/08959374000140011301","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/08959374000140011301","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T17:42:05Z","timestamp":1777398125000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/08959374000140011301"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,12]]},"references-count":16,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2000,12]]}},"alternative-id":["10.1177\/08959374000140011301"],"URL":"https:\/\/doi.org\/10.1177\/08959374000140011301","relation":{},"ISSN":["0895-9374","1544-0737"],"issn-type":[{"value":"0895-9374","type":"print"},{"value":"1544-0737","type":"electronic"}],"subject":[],"published":{"date-parts":[[2000,12]]}}}