{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T13:18:40Z","timestamp":1787836720542,"version":"build-2784847793"},"reference-count":23,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[1995,11,1]],"date-time":"1995-11-01T00:00:00Z","timestamp":815184000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Adv Dent Res."],"published-print":{"date-parts":[[1995,11]]},"abstract":"<jats:p>Abstract\u2014To determine the ability of animal caries models to evaluate the cariostatic potential of fluoride dentifrices, we examined four different coronal caries models. These currently used rat caries models were: Francis' hypomineralized area model, Gaffar's CARA rat model, the Connecticut model, and the Indiana model. Available data indicated that all of these models were capable of detecting significant cariostatic benefits from clinically proven fluoride dentifrices. For the most part, these animal models were also able to demonstrate a response to increasing concentrations of fluoride, particularly if the fluoride was provided in an ionic rather than a complexed form. Data were also presented which indicated the potential for animal caries models to be used to predict the clinical benefits of non-fluoride systems as well as the utility of fluoride systems for the prevention of root-surface caries. It is concluded that animal caries models play a significant role in the development and evaluation of fluoride and other systems for the clinical prevention of dental caries.<\/jats:p>","DOI":"10.1177\/08959374950090030301","type":"journal-article","created":{"date-parts":[[2009,1,8]],"date-time":"2009-01-08T19:41:28Z","timestamp":1231443688000},"page":"198-207","source":"Crossref","is-referenced-by-count":28,"title":["Animal Caries Models for Evaluating Fluoride Dentifrices"],"prefix":"10.1177","volume":"9","author":[{"given":"G.K.","family":"Stookey","sequence":"first","affiliation":[{"name":"Indiana University School of Dentistry Oral Health Research Institute 415 N. Lansing Street Indianapolis, Indiana 46202-2876"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.M.","family":"Warrick","sequence":"additional","affiliation":[{"name":"Indiana University School of Dentistry Oral Health Research Institute 415 N. Lansing Street Indianapolis, Indiana 46202-2876"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.L.","family":"Miller","sequence":"additional","affiliation":[{"name":"Indiana University School of Dentistry Oral Health Research Institute 415 N. Lansing Street Indianapolis, Indiana 46202-2876"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.L.","family":"Greene","sequence":"additional","affiliation":[{"name":"Indiana University School of Dentistry Oral Health Research Institute 415 N. Lansing Street Indianapolis, Indiana 46202-2876"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[1995,11,1]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.1980.tb00297.x"},{"key":"atypb2","volume-title":"FDI Annual World Dental Congress","author":"Best JM"},{"key":"atypb3","unstructured":"Bowen WH, Pearson S., Young DA, Thibodeau E. (1985). The effect of partial desalivation on coronal and root surface caries in the rat. In: Factors relating to demineralisation and remineralisation of the teeth. Leach SA, Editor. Oxford: IRL Press Ltd., pp. 243-250."},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1177\/00220345770560080301"},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.1177\/00220345870660101401"},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9969(66)90183-X"},{"key":"atypb7","doi-asserted-by":"publisher","DOI":"10.1007\/BF02405059"},{"key":"atypb8","doi-asserted-by":"publisher","DOI":"10.14219\/jada.archive.1988.0128"},{"key":"atypb9","doi-asserted-by":"publisher","DOI":"10.1177\/00220345580370060901"},{"key":"atypb10","unstructured":"Keyes PH (1968). Similarities and differences in dental caries in various species. In: Art and science of dental caries research . Harris RS, editor. 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In: Foods, nutrition and dental health. Vol. 5. Hefferren JJ, Koehler, HM , Osborn JC, editors. Chicago, IL: American Dental Association, pp. 7-21."},{"key":"atypb17","doi-asserted-by":"publisher","DOI":"10.1177\/00220345770560112201"},{"key":"atypb18","first-page":"75","volume":"1","author":"Schmid R.","year":"1989","journal-title":"J Clin Dent"},{"key":"atypb19","first-page":"241","volume":"73","author":"Shaffer JB","year":"1994","journal-title":"J Dent Res"},{"key":"atypb20","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-109-27313"},{"key":"atypb21","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9969(74)90203-9"},{"key":"atypb22","volume-title":"Animal models in cariology. 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