{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T11:14:35Z","timestamp":1777547675726,"version":"3.51.4"},"reference-count":64,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[1997,11,1]],"date-time":"1997-11-01T00:00:00Z","timestamp":878342400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Adv Dent Res."],"published-print":{"date-parts":[[1997,11]]},"abstract":"<jats:p>The availability of monoclonal and polyclonal antibodies directed toward the recognition of epitopes in a variety of extracellular matrix components of the dentition represents a powerful tool in the investigation of the structure and biology of dental tissues in health and disease. The immunolocalization of both whole molecule structures and specific regions of molecules has the potential to yield information on tooth development, the effects of aging, changes in tooth structure during the initiation and progression of the caries process, together with the response of the tooth to restorative treatment. This review reports on current research to elucidate the role of extracellular matrices of enamel, dentin, cementum, and bone. Attention is directed at the use of antibodies toward the small leucine-rich proteoglycans such as decorin and biglycan, in addition to their glycosaminoglycan chains. Antibodies are also being developed toward dental tissue-specific macromolecules such as phosphophoryn and amelogenin; the use of these antibodies will increase our understanding of the role of these macromolecules in mineralized tissues.<\/jats:p>","DOI":"10.1177\/08959374970110041601","type":"journal-article","created":{"date-parts":[[2009,1,8]],"date-time":"2009-01-08T19:41:28Z","timestamp":1231443688000},"page":"478-486","source":"Crossref","is-referenced-by-count":25,"title":["The Use of Immunohistochemistry in Understanding the Structure and Function of the Extracellular Matrix of Dental Tissues"],"prefix":"10.1177","volume":"11","author":[{"given":"R.C.","family":"Hall","sequence":"first","affiliation":[{"name":"Department of Basic Dental Science University of Wales College of Medicine Heath Park, Cardiff, CF4 4XY, UK, Anatomy Unit School of Molecular and Medical Biosciences University of Wales College Cardiff Museum Avenue, PO Box 911 Cardiff, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Embery","sequence":"additional","affiliation":[{"name":"Department of Basic Dental Science University of Wales College of Medicine Heath Park, Cardiff, CF4 4XY, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1997,11,1]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1177\/00220345900690011201"},{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.1988.tb01020.x"},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1016\/S0934-8832(11)80132-0"},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1177\/38.11.2212616"},{"key":"atypb5","doi-asserted-by":"crossref","first-page":"5250","DOI":"10.1016\/S0021-9258(18)42759-7","volume":"267","author":"Bidanset DJ","year":"1992","journal-title":"J Biol Chem"},{"key":"atypb6","first-page":"346","volume":"267","author":"Blochberger TC","year":"1992","journal-title":"J Biol Chem"},{"key":"atypb7","doi-asserted-by":"publisher","DOI":"10.1177\/41.1.8417108"},{"key":"atypb8","doi-asserted-by":"crossref","first-page":"8843","DOI":"10.1016\/S0021-9258(18)32133-1","volume":"258","author":"Caterson B.","year":"1983","journal-title":"J Biol Chem"},{"key":"atypb9","first-page":"386","volume":"44","author":"Caterson B.","year":"1985","journal-title":"Proc FASEB"},{"key":"atypb10","doi-asserted-by":"publisher","DOI":"10.3109\/03008209609021494"},{"key":"atypb11","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-47-13084P"},{"key":"atypb12","doi-asserted-by":"publisher","DOI":"10.1038\/307650a0"},{"key":"atypb13","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1007\/BF00514327","volume":"81","author":"Danscher G.","year":"1984","journal-title":"Histochem"},{"key":"atypb14","doi-asserted-by":"publisher","DOI":"10.1042\/bj1990699"},{"key":"atypb15","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/S0021-9258(18)56108-1","volume":"189","author":"Dziewiatkowski DD","year":"1951","journal-title":"J Biol Chem"},{"key":"atypb16","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(81)90221-9"},{"key":"atypb17","doi-asserted-by":"publisher","DOI":"10.1007\/BF02012545"},{"key":"atypb18","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9969(95)00068-Z"},{"key":"atypb19","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1016\/0019-2791(71)90496-4","volume":"8","author":"Faulk W.","year":"1971","journal-title":"Immunocytochem"},{"key":"atypb20","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/0304-4165(76)90351-2","volume":"437","author":"Fransson LA","year":"1976","journal-title":"Biochim Biophys Acta"},{"key":"atypb21","doi-asserted-by":"publisher","DOI":"10.1007\/BF01320911"},{"key":"atypb22","doi-asserted-by":"crossref","first-page":"11874","DOI":"10.1016\/S0021-9258(19)50281-2","volume":"268","author":"Funderburgh JL","year":"1993","journal-title":"J Biol Chem"},{"key":"atypb23","doi-asserted-by":"publisher","DOI":"10.1177\/17.3.156"},{"key":"atypb24","doi-asserted-by":"publisher","DOI":"10.1007\/BF02557834"},{"key":"atypb25","doi-asserted-by":"publisher","DOI":"10.1016\/0167-5699(86)90108-8"},{"key":"atypb26","author":"Hall RC","year":"1997","journal-title":"Arch Oral Biol"},{"key":"atypb27","doi-asserted-by":"crossref","first-page":"6898","DOI":"10.1016\/S0021-9258(18)83516-5","volume":"264","author":"Hedbom E.","year":"1989","journal-title":"J Biol Chem"},{"key":"atypb28","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)74250-1"},{"key":"atypb29","doi-asserted-by":"publisher","DOI":"10.1042\/bj3020527"},{"key":"atypb30","doi-asserted-by":"publisher","DOI":"10.1016\/0968-0004(94)90090-6"},{"key":"atypb31","doi-asserted-by":"publisher","DOI":"10.1038\/256495a0"},{"key":"atypb32","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.271.8.4431"},{"key":"atypb33","doi-asserted-by":"publisher","DOI":"10.1007\/BF01923585"},{"key":"atypb34","doi-asserted-by":"crossref","first-page":"3695","DOI":"10.4049\/jimmunol.149.11.3695","volume":"149","author":"Krumdieck R.","year":"1992","journal-title":"J Immunol"},{"key":"atypb35","doi-asserted-by":"publisher","DOI":"10.1177\/38.4.2319121"},{"key":"atypb36","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1955.tb40055.x"},{"key":"atypb37","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-0436.1992.tb00775.x"},{"key":"atypb38","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.bi.47.070178.002125"},{"key":"atypb39","first-page":"651","volume":"91","author":"McManus Jfa","year":"1950","journal-title":"I. Periodic acid methods. J Exp Med"},{"key":"atypb40","doi-asserted-by":"publisher","DOI":"10.1038\/scientificamerican1080-66"},{"key":"atypb41","first-page":"393","volume":"211","author":"Milstein C.","year":"1981","journal-title":"Proc R Soc Lond"},{"key":"atypb42","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1111\/j.1749-6632.1963.tb16654.x","volume":"106","author":"Mowry RW","year":"1963","journal-title":"Ann NYAcad Sci"},{"key":"atypb43","doi-asserted-by":"publisher","DOI":"10.1111\/j.1699-0463.1952.tb00200.x"},{"key":"atypb44","doi-asserted-by":"publisher","DOI":"10.1042\/bj2240941"},{"key":"atypb45","doi-asserted-by":"publisher","DOI":"10.1042\/bj2180877"},{"key":"atypb46","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198404123101518"},{"key":"atypb47","doi-asserted-by":"publisher","DOI":"10.1177\/29.5.6166664"},{"key":"atypb48","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.270.15.8877"},{"key":"atypb49","doi-asserted-by":"publisher","DOI":"10.1042\/bj2520313"},{"key":"atypb50","doi-asserted-by":"publisher","DOI":"10.1042\/bj1970213"},{"key":"atypb51","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9969(93)90127-8"},{"key":"atypb52","doi-asserted-by":"publisher","DOI":"10.3109\/03008209509016995"},{"key":"atypb53","doi-asserted-by":"publisher","DOI":"10.1177\/13.3.211"},{"key":"atypb54","first-page":"256","volume":"10","author":"Spicer SS","year":"1961","journal-title":"Lab Invest"},{"key":"atypb55","first-page":"477","volume":"91","author":"Steedman HF","year":"1950","journal-title":"J Micro Sci"},{"key":"atypb56","doi-asserted-by":"publisher","DOI":"10.1007\/BF00307784"},{"key":"atypb57","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.270.35.20712"},{"key":"atypb58","doi-asserted-by":"publisher","DOI":"10.1177\/38.3.1689334"},{"key":"atypb59","doi-asserted-by":"publisher","DOI":"10.1177\/39.1.1898498"},{"key":"atypb60","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1016\/S0021-9258(17)33868-1","volume":"251","author":"Toole BP","year":"1976","journal-title":"J Biol Chem"},{"key":"atypb61","doi-asserted-by":"publisher","DOI":"10.1159\/000144313"},{"key":"atypb62","doi-asserted-by":"publisher","DOI":"10.1042\/bj2230587"},{"key":"atypb63","first-page":"41","volume":"11","author":"Wilson RW","year":"1988","journal-title":"J Clin Immunoassay"},{"key":"atypb64","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9969(95)00138-7"}],"container-title":["Advances in Dental Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/08959374970110041601","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/08959374970110041601","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T17:41:50Z","timestamp":1777398110000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/08959374970110041601"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,11]]},"references-count":64,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1997,11]]}},"alternative-id":["10.1177\/08959374970110041601"],"URL":"https:\/\/doi.org\/10.1177\/08959374970110041601","relation":{},"ISSN":["0895-9374","1544-0737"],"issn-type":[{"value":"0895-9374","type":"print"},{"value":"1544-0737","type":"electronic"}],"subject":[],"published":{"date-parts":[[1997,11]]}}}