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Osseous destructive diseases associated with excessive mammalian collagenase (matrix metalloproteinase) activity and collagen breakdown include malignancy, arthritis, and periodontitis. However, apart from the significant antimatrix metalloproteinase effects of TCs, TCs\/CMTs are also potent inhibitors of osteoclast function (i.e., anti-resorptive). Thus, TCs can affect several parameters of osteoclast function and consequently inhibit bone resorption by (1) altering intracellular calcium concentration and interacting with the putative calcium receptor; (2) decreasing ruffled border area; (3) diminishing acid production; (4) diminishing the secretion of lysosomal cysteine proteinases (cathepsins); (5) inducing cell retraction by affecting podosomes; (6) inhibiting osteoclast gelatinase activity; (7) selectively inhibiting osteoclast ontogeny or development; and (8) inducing apoptosis or programmed cell death of osteoclasts. TCs\/CMTs, as anti-resorptive drugs, may act similarly to bisphosphonates and primarily affect osteoclast function.<\/jats:p>","DOI":"10.1177\/08959374980120012101","type":"journal-article","created":{"date-parts":[[2009,1,8]],"date-time":"2009-01-08T19:41:28Z","timestamp":1231443688000},"page":"56-62","source":"Crossref","is-referenced-by-count":30,"title":["Effects of Tetracyclines on Bone Metabolism"],"prefix":"10.1177","volume":"12","author":[{"given":"A.T.","family":"Vernillo","sequence":"first","affiliation":[{"name":"Division of Basic Sciences, Unit of Oral Medicine and Pathology, New York University College of Dentistry, 345 E. 24th Street, New York, NY 10010"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.R.","family":"Rifkin","sequence":"additional","affiliation":[{"name":"Division of Basic Sciences, Unit of Oral Medicine and Pathology, New York University College of Dentistry, 345 E. 24th Street, New York, NY 10010"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1998,11,1]]},"reference":[{"key":"atypb1","first-page":"309","volume":"69","author":"Athanasou NA","year":"1988","journal-title":"Br J Exp Pathol"},{"key":"atypb2","doi-asserted-by":"crossref","unstructured":"Aubin JE, Heersche JNM, Kanehisa J, Okuda A, Turksen K, Opas M (1992). 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