{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T11:15:11Z","timestamp":1777547711126,"version":"3.51.4"},"reference-count":27,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[1998,11,1]],"date-time":"1998-11-01T00:00:00Z","timestamp":909878400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Adv Dent Res."],"published-print":{"date-parts":[[1998,11]]},"abstract":"<jats:p>The effect of a new non-antimicrobial analog of tetracycline (CMT-8) on bone loss in ovariectomized (OVX) rats was examined. Three-month-old female rats were ovariectomized, and one week later, were distributed into 3 groups: sham-operated non-OVX controls, vehicle-treated OVX controls, and CMT-8-treated OVX rats. After 145 days of daily CMT-8 administration, the intact femurs were dissected and examined by several histological and histomorphometric techniques. OVX significantly (p &lt; 0.01) decreased trabecular bone volume by 53.4% in the metaphyses compared with sham-operated controls. CMT-8 therapy produced a significant (p &lt; 0.05) inhibition of trabecular bone loss and also induced bone formation in the OVX rats. Of interest, the newly synthesized bone in the CMT-treated OVX rats was found to increase the \"connectivity\" of the trabecular \"struts\" by bridging the adjacent longitudinal bone trabeculae, forming dense, platelike bone trabeculae. These results strongly suggest that long-term CMT-8 therapy effectively inhibits bone loss after OVX, not only by inhibiting bone resorption but also by inducing new bone formation in the trabecular areas of long bones.<\/jats:p>","DOI":"10.1177\/08959374980120012501","type":"journal-article","created":{"date-parts":[[2009,1,8]],"date-time":"2009-01-08T19:41:28Z","timestamp":1231443688000},"page":"76-81","source":"Crossref","is-referenced-by-count":7,"title":["Long-Term Therapy with a New Chemically Modified Tetracycline (CMT-8) Inhibits Bone Loss in Femurs of Ovariectomized Rats"],"prefix":"10.1177","volume":"12","author":[{"given":"T.","family":"Sasaki","sequence":"first","affiliation":[{"name":"Department of Anatomy, School of Dentistry, Showa University, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8555, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.S.","family":"Ramamurthy","sequence":"additional","affiliation":[{"name":"Department of Oral Biology and Pathology, School of Dental Medicine, Health Sciences Center, State University of New York at Stony Brook, Stony Brook, New York 11794-8700, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.M.","family":"Golub","sequence":"additional","affiliation":[{"name":"Department of Oral Biology and Pathology, School of Dental Medicine, Health Sciences Center, State University of New York at Stony Brook, Stony Brook, New York 11794-8700, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1998,11,1]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00675623"},{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.5650050310"},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.1984.tb01334.x"},{"key":"atypb4","first-page":"24","volume":"68","author":"Golub LM","year":"1990","journal-title":"Res Commun Chem Pathol Pharmacol"},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.1007\/BF01946671"},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.1016\/S8756-3282(97)00221-4"},{"key":"atypb7","doi-asserted-by":"publisher","DOI":"10.1016\/8756-3282(91)90030-M"},{"key":"atypb8","doi-asserted-by":"publisher","DOI":"10.1016\/S0169-6009(08)80037-2"},{"key":"atypb9","doi-asserted-by":"publisher","DOI":"10.1210\/endo-122-2-624"},{"key":"atypb10","doi-asserted-by":"publisher","DOI":"10.1016\/0169-6009(91)90124-I"},{"key":"atypb11","doi-asserted-by":"publisher","DOI":"10.1016\/S0169-6009(08)80050-5"},{"key":"atypb12","doi-asserted-by":"publisher","DOI":"10.1002\/ar.1092360303"},{"key":"atypb13","doi-asserted-by":"publisher","DOI":"10.1016\/8756-3282(91)90033-F"},{"key":"atypb14","doi-asserted-by":"publisher","DOI":"10.1016\/8756-3282(93)90248-9"},{"key":"atypb15","first-page":"105","volume":"75","author":"Ramamurthy NS","year":"1996","journal-title":"J Dent Res"},{"key":"atypb16","unstructured":"Rifkin BR, Golub LM, Sanavi F., Vernillo AT, Kleckner AP, McNamara TF, et al. 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