{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:08:37Z","timestamp":1787018917201,"version":"build-2736575974"},"reference-count":26,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2020,5,19]],"date-time":"2020-05-19T00:00:00Z","timestamp":1589846400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"The study was initiated and funded by Gambro and Fresenius Medical Care","award":["n.a."],"award-info":[{"award-number":["n.a."]}]},{"name":"Gambro AB"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Perit Dial Int"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Patients on peritoneal dialysis (PD) may suffer from sodium (Na) and fluid overload, hypertension and increased cardiovascular risk. Low-Na dialysis solution, by increasing the diffusive removal of Na, might improve blood pressure (BP) management.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>A glucose-compensated, low-Na PD solution (112 mmol\/L Na and 2% glucose) was compared to a standard-Na solution (133 mmol\/L Na and 1.5% glucose) in a prospective, randomised, single-blind study in hypertensive patients on PD. One daily exchange of the standard dialysis regimen was substituted by either of the study solutions for 6 months. The primary outcome (response) was defined as either a decrease of 24-h systolic BP (SBP) by \u22656 mmHg or a fall in BP requiring a medical intervention (e.g. a reduction of antihypertensive medication) at 8 weeks.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>One hundred twenty-three patients were assessed for efficacy. Response criteria were achieved in 34.5% and 29.1% of patients using low- and standard-Na solutions, respectively ( p = 0.51). Small reductions in 24 h, office, and self-measured BP were observed, more marked with low-Na than with standard-Na solution, but only the between-group difference for self-measured SBP and diastolic BP was significant ( p = 0.002 and p = 0.003). Total body water decreased in the low-Na group and increased in the control group, but between-group differences were not significant. Hypotension and dizziness occurred in 27.0% and in 11.1% of patients in the low-Na group and in 16.9% and 4.6% in the control group, respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Superiority of low-Na PD solution over standard-Na solution for control of BP could not be shown. The once daily use of a low-Na PD solution was associated with more hypotensive episodes, suggesting the need to reassess the overall concept of how Na-reduced solutions might be incorporated within the treatment schedule.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0896860820924136","type":"journal-article","created":{"date-parts":[[2020,5,19]],"date-time":"2020-05-19T07:24:22Z","timestamp":1589873062000},"page":"446-454","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":11,"title":["Single-dwell treatment with a low-sodium solution in hypertensive peritoneal dialysis patients"],"prefix":"10.1177","volume":"40","author":[{"given":"Simon","family":"Davies","sequence":"first","affiliation":[{"name":"Faculty of Medicine and Health Sciences, Keele University, Staffordshire, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B\u00f6rje","family":"Haraldsson","sequence":"additional","affiliation":[{"name":"Department of Physiology, University of Gothenburg, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois","family":"Vrtovsnik","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Xavier Bichat Hospital, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vedat","family":"Schwenger","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Katharinenhospital, Stuttgart, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stanley","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Nephrology, The Royal London Hospital, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre","family":"Klein","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Hospital Louis Pasteur, Colmar, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saynab","family":"Atiye","sequence":"additional","affiliation":[{"name":"Fresenius Medical Care, Bad Homburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2554-0711","authenticated-orcid":false,"given":"Adelheid","family":"Gauly","sequence":"additional","affiliation":[{"name":"Fresenius Medical Care, Bad Homburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2020,5,19]]},"reference":[{"key":"bibr1-0896860820924136","doi-asserted-by":"publisher","DOI":"10.1016\/j.jash.2011.02.004"},{"key":"bibr2-0896860820924136","doi-asserted-by":"publisher","DOI":"10.1097\/01.ASN.0000019641.41496.1E"},{"key":"bibr3-0896860820924136","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)60212-9"},{"key":"bibr4-0896860820924136","doi-asserted-by":"publisher","DOI":"10.1159\/000074924"},{"key":"bibr5-0896860820924136","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2001.060002767.x"},{"key":"bibr6-0896860820924136","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2016.02.029"},{"key":"bibr7-0896860820924136","doi-asserted-by":"publisher","DOI":"10.1177\/089686080902900510"},{"key":"bibr8-0896860820924136","doi-asserted-by":"publisher","DOI":"10.1080\/08860220701260461"},{"key":"bibr9-0896860820924136","doi-asserted-by":"publisher","DOI":"10.1177\/089686080102100110"},{"issue":"1","key":"bibr10-0896860820924136","first-page":"66","volume":"45","author":"Nakayama M","year":"1996","journal-title":"Clin Nephrol"},{"issue":"6","key":"bibr11-0896860820924136","first-page":"357","volume":"41","author":"Nakayama M","year":"1994","journal-title":"Clin Nephrol"},{"issue":"3","key":"bibr12-0896860820924136","doi-asserted-by":"crossref","first-page":"S131","DOI":"10.1177\/089686080802803s25","volume":"28","author":"Rippe B","year":"2008","journal-title":"Perit Dial Int"},{"key":"bibr13-0896860820924136","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfn668"},{"key":"bibr14-0896860820924136","unstructured":"Committee for Proprietary Medicinal Products. Note for guidance on clinical investigation of medicinal products in the treatment of hypertension. European Medicines Agency; 2004. https:\/\/www.ema.europa.eu\/en\/documents (2004, accessed 11 May 2020)."},{"key":"bibr15-0896860820924136","doi-asserted-by":"publisher","DOI":"10.1097\/00126097-200202000-00002"},{"key":"bibr16-0896860820924136","doi-asserted-by":"publisher","DOI":"10.1111\/j.1542-4758.2007.00148.x"},{"key":"bibr17-0896860820924136","doi-asserted-by":"publisher","DOI":"10.3747\/pdi.2015.00305"},{"key":"bibr18-0896860820924136","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.114.04334"},{"key":"bibr19-0896860820924136","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfh856"},{"issue":"7","key":"bibr20-0896860820924136","first-page":"1224","volume":"32","author":"Ravel VA","year":"2016","journal-title":"Nephrol Dial Transplant"},{"key":"bibr21-0896860820924136","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2012.04.026"},{"key":"bibr22-0896860820924136","doi-asserted-by":"publisher","DOI":"10.1186\/s41100-016-0034-2"},{"key":"bibr23-0896860820924136","doi-asserted-by":"publisher","DOI":"10.3747\/pdi.2009.00068"},{"key":"bibr24-0896860820924136","doi-asserted-by":"publisher","DOI":"10.1046\/j.1525-139X.2002.00101.x"},{"key":"bibr25-0896860820924136","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2015.07.031"},{"key":"bibr26-0896860820924136","doi-asserted-by":"publisher","DOI":"10.3747\/pdi.2018.00120"}],"container-title":["Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0896860820924136","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0896860820924136","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0896860820924136","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T22:33:16Z","timestamp":1777674796000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0896860820924136"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5,19]]},"references-count":26,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2020,9]]}},"alternative-id":["10.1177\/0896860820924136"],"URL":"https:\/\/doi.org\/10.1177\/0896860820924136","relation":{},"ISSN":["0896-8608","1718-4304"],"issn-type":[{"value":"0896-8608","type":"print"},{"value":"1718-4304","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,5,19]]}}}