{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T01:07:25Z","timestamp":1790816845745,"version":"4.1.0"},"reference-count":21,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2021,8,9]],"date-time":"2021-08-09T00:00:00Z","timestamp":1628467200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2021,8,9]],"date-time":"2021-08-09T00:00:00Z","timestamp":1628467200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Perit Dial Int"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>This retrospective cohort study investigated the characteristics and outcomes of the end-stage kidney disease (ESKD) patients treated with incremental peritoneal dialysis (PD) at a large academic centre.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>ESKD patients initiating PD with a dialysate volume \u22646 L\/day were analysed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      One hundred and seventy-five patients were included and were followed up for 352.6 patient-years. The baseline residual kidney function (RKF) was 8.3 \u00b1 3.4 mL\/min\/1.73 m\n                      <jats:sup>2<\/jats:sup>\n                      . The unadjusted 1- to 5-year patient survival rate was 89.6%, 80.4%, 65.4%, 62.7% and 48.8%, respectively, and the corresponding time on PD therapy rate was 95.1%, 89.1%, 89.1%, 82.4% and 77.6%. Greater initial PD dose (hazard ratio = 1.608, 95% confidence interval 1.089\u20132.375) was associated with death after adjusting for age, Charlson comorbidity index (CCI), haemodialysis prior to PD, assisted PD and baseline RKF, likely as a result of residual confounding. There was no association with PD discontinuation. The average peritonitis rate and hospitalisation rate were 0.122 and 0.645 episodes per patient-year, respectively. The dialysate volume increased from 4.5 (4.3\u20135.7) L\/day to 8.0 (6.0\u20139.8) L\/day at 5 years. Fifty-seven (32.6%) patients graduated to full-dose PD at a median time of 10.3 (6.2, 15.7) months. Male sex, greater body mass index and lower baseline serum albumin were risk factors for increasing PD dose to over 6 L\/day within 1 year.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Incremental PD is a safe approach to initiate dialysis, and it offers satisfactory outcomes. Close monitoring, comprehensive evaluation of clinical responses and prompt adjustment of the prescription as needed play a crucial role in this patient-centred treatment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/08968608211036796","type":"journal-article","created":{"date-parts":[[2021,8,9]],"date-time":"2021-08-09T04:32:25Z","timestamp":1628483545000},"page":"387-393","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":15,"title":["Incremental peritoneal dialysis in incident end-stage kidney disease patients"],"prefix":"10.1177","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7312-8860","authenticated-orcid":false,"given":"Hao","family":"Yan","sequence":"first","affiliation":[{"name":"Department of Nephrology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, People\u2019s Republic of China"},{"name":"Division of Nephrology, University Health Network, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zita","family":"Abreu","sequence":"additional","affiliation":[{"name":"Division of Nephrology, University Health Network, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanne M","family":"Bargman","sequence":"additional","affiliation":[{"name":"Division of Nephrology, University Health Network, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2021,8,9]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40620-018-00577-9"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40620-017-0403-0"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1177\/2054358116679131"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-46654-2"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40620-016-0344-z"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2016.08.019"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1000552"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.3747\/pdi.2012.00046"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.09301010"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.3747\/pdi.2013.00328"},{"key":"e_1_3_3_12_2","first-page":"93","article-title":"Incremental dialysis with automated peritoneal dialysis","volume":"19","author":"Neri L","year":"2003","unstructured":"Neri L, Viglino G, Cappelletti A, et al. Incremental dialysis with automated peritoneal dialysis. Adv Perit Dial 2003; 19: 93\u201396.","journal-title":"Adv Perit Dial"},{"key":"e_1_3_3_13_2","article-title":"Incremental peritoneal dialysis: effects on the choice of dialysis modality, residual renal function and adequacy","volume":"108","author":"Viglino G","year":"2008","unstructured":"Viglino G, Neri L, Barbieri S. Incremental peritoneal dialysis: effects on the choice of dialysis modality, residual renal function and adequacy. Kidney Int Suppl 2008; 108: S52\u201355.","journal-title":"Kidney Int Suppl"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0272-6386(99)70094-6"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1177\/089686080002000407"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nefro.2016.01.006"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.3747\/pdi.2011.00027"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1177\/0896860819895362"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfn372"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1177\/0896860820911521"},{"key":"e_1_3_3_21_2","doi-asserted-by":"crossref","unstructured":"Boudville N de Moraes TP. 2005 Guidelines on targets for solute and fluid removal in adults being treated with chronic peritoneal dialysis: 2019 update of the literature and revision of recommendations. 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