{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T15:04:35Z","timestamp":1784300675190,"version":"3.55.0"},"reference-count":30,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2021,9,27]],"date-time":"2021-09-27T00:00:00Z","timestamp":1632700800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000291","name":"Kidney Research UK","doi-asserted-by":"publisher","award":["TF_013_20151127"],"award-info":[{"award-number":["TF_013_20151127"]}],"id":[{"id":"10.13039\/501100000291","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Perit Dial Int"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>For patients on peritoneal dialysis (PD), the deleterious effects of high concentrations of dialysate glucose on the peritoneal membrane are well-documented. Systemic effects of peritoneally absorbed glucose are more poorly defined. Using continuous glucose monitoring (CGM), we aimed to describe 24-h glycaemic profiles of PD patients without diabetes and compare with non-dialysis controls with stage 5 chronic kidney disease (CKD-5).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>In this cross-sectional, case-control study, 15 patients on PD (9 automated PD (APD) and 6 continuous ambulatory PD (CAPD)) and 16 CKD-5 controls underwent 72 h of CGM and metabolic profiling. CGM was used to derive average glucose concentrations and within-participant standard deviation (SD) of glucose. Data were analysed for the whole 72-h monitoring period and as daytime (09.00 to 21.00) and night-time (21.00 to 09.00).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Average glucose concentrations and within-participant SD of glucose for the whole monitoring period were not different between the three groups ( p \u2265 0.5). Daytime average glucose concentrations were also similar across the three groups ( p = 0.729). APD was associated with a significantly higher nocturnal glucose than CAPD (5.25 mmol\/L \u00b1 0.65 vs. 4.28 \u00b1 0.5, p = 0.026). A significant drop in nocturnal glucose compared with daytime average seen in both CAPD patients and controls was absent in APD patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Systematically different glycaemic patterns were observed in non-diabetic APD and CAPD patients, including an absence of physiological nocturnal glucose dipping in patients on APD. Comprehensive CGM data sets highlight subtleties not appreciated by traditional metabolic biomarkers; this has implications when choosing the most appropriate outcome measures in future research addressing the metabolic impact of PD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/08968608211047787","type":"journal-article","created":{"date-parts":[[2021,9,28]],"date-time":"2021-09-28T00:10:36Z","timestamp":1632787836000},"page":"497-504","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":9,"title":["24-h Glycaemic profiles in peritoneal dialysis patients and non-dialysis controls with advanced kidney disease"],"prefix":"10.1177","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2779-9620","authenticated-orcid":false,"given":"Jennifer","family":"Williams","sequence":"first","affiliation":[{"name":"Diabetes and Vascular Medicine Research Centre, NIHR Exeter Clinical Research Facility, University of Exeter College of Medicine and Health, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Gilchrist","sequence":"additional","affiliation":[{"name":"Diabetes and Vascular Medicine Research Centre, NIHR Exeter Clinical Research Facility, University of Exeter College of Medicine and Health, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William David","family":"Strain","sequence":"additional","affiliation":[{"name":"Diabetes and Vascular Medicine Research Centre, NIHR Exeter Clinical Research Facility, University of Exeter College of Medicine and Health, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donald","family":"Fraser","sequence":"additional","affiliation":[{"name":"Wales Kidney Research Unit, Cardiff University, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Shore","sequence":"additional","affiliation":[{"name":"Diabetes and Vascular Medicine Research Centre, NIHR Exeter Clinical Research Facility, University of Exeter College of Medicine and Health, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2021,9,27]]},"reference":[{"key":"bibr1-08968608211047787","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)61272-0"},{"key":"bibr2-08968608211047787","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)61350-6"},{"key":"bibr3-08968608211047787","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1992.196"},{"key":"bibr4-08968608211047787","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfx250"},{"key":"bibr5-08968608211047787","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0087891"},{"key":"bibr6-08968608211047787","doi-asserted-by":"publisher","DOI":"10.2337\/dc12-2148"},{"key":"bibr7-08968608211047787","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0155564"},{"key":"bibr8-08968608211047787","doi-asserted-by":"publisher","DOI":"10.3747\/pdi.2015.00182"},{"key":"bibr9-08968608211047787","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.03170315"},{"key":"bibr10-08968608211047787","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.09301209"},{"key":"bibr11-08968608211047787","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2006070772"},{"key":"bibr12-08968608211047787","doi-asserted-by":"publisher","DOI":"10.2337\/dc10-0917"},{"key":"bibr13-08968608211047787","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1089\/dia.2015.0417","volume":"18","author":"Rodbard D","year":"2016","journal-title":"Diabetes Technol Ther"},{"key":"bibr14-08968608211047787","first-page":"213","volume":"20","author":"Schwing WD","year":"2004","journal-title":"Adv Perit Dial Conf Perit Dial"},{"key":"bibr15-08968608211047787","first-page":"34","volume":"31","author":"Okada E","year":"2015","journal-title":"Adv Perit Dial"},{"key":"bibr16-08968608211047787","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2003.00209.x"},{"key":"bibr17-08968608211047787","doi-asserted-by":"publisher","DOI":"10.2337\/dc12-0840"},{"key":"bibr18-08968608211047787","doi-asserted-by":"publisher","DOI":"10.1007\/s13300-016-0223-6"},{"key":"bibr19-08968608211047787","unstructured":"Flowers K, Kirk A, Turner L, et al. 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