{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,10]],"date-time":"2026-05-10T08:51:16Z","timestamp":1778403076866,"version":"3.51.4"},"reference-count":41,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2022,3,16]],"date-time":"2022-03-16T00:00:00Z","timestamp":1647388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Baxter Ltd.","award":["04-080-5103"],"award-info":[{"award-number":["04-080-5103"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Perit Dial Int"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Thymus and activation-regulated chemokine (TARC), which induces a Th2-dominated inflammation, is a well-known biomarker that reflects the severity of atopic dermatitis. The present study aimed to evaluate TARC as a Th2-associated marker with chronic kidney disease-associated pruritus (CKD-aP) in patients with peritoneal dialysis (PD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>This single-centre cross-sectional study included patients who underwent PD in our hospital between August 2020 and July 2021. The severity and impaired quality of life (QOL) of CKD-aP were assessed using the visual analogue scale (VAS) and Japanese version of the 5-D itch scale (5D-J), respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      A total of 48 patients with PD were included in the present study. Age and dialysis vintage were (mean \u00b1 SD) 64.8 \u00b1 12.0 year and (median (IQR)) 38.5 (11.5\u201391.5) month, respectively. VAS and 5D-J scores were 3.3 \u00b1 2.0 and 10.5 (9.0\u201312.0), respectively. Serum TARC level was 481.5 (278.9\u2013603.4) pg\/mL (upper limits of normal 450 pg\/mL) and significantly correlated with VAS (\n                      <jats:italic>r<\/jats:italic>\n                      = 0.39,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.006) and 5D-J score (\n                      <jats:italic>r<\/jats:italic>\n                      = 0.37,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.009). Multivariate linear analysis revealed that higher serum TARC level was significantly associated with VAS (\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001) and 5D-J score (\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001). Furthermore, the serum brain natriuretic peptide level tended to be associated with VAS (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.060) and 5D-J score (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.029).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Serum TARC level is an independent predictor of the severity and impaired QOL of CKD-aP in patients with PD, and TARC might be involved in the pathogenesis of CKD-aP.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/08968608221085432","type":"journal-article","created":{"date-parts":[[2022,3,17]],"date-time":"2022-03-17T02:50:10Z","timestamp":1647485410000},"page":"415-424","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Serum thymus and activation-regulated chemokine level is associated with the severity of chronic kidney disease-associated pruritus in patients undergoing peritoneal dialysis"],"prefix":"10.1177","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2498-2793","authenticated-orcid":false,"given":"Takashin","family":"Nakayama","sequence":"first","affiliation":[{"name":"Division of Endocrinology, Metabolism, and Nephrology, Department of Internal Medicine, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7652-6506","authenticated-orcid":false,"given":"Kohkichi","family":"Morimoto","sequence":"additional","affiliation":[{"name":"Apheresis and Dialysis Center, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5173-1263","authenticated-orcid":false,"given":"Kiyotaka","family":"Uchiyama","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Metabolism, and Nephrology, Department of Internal Medicine, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ei","family":"Kusahana","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Metabolism, and Nephrology, Department of Internal Medicine, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoki","family":"Washida","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Metabolism, and Nephrology, Department of Internal Medicine, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan"},{"name":"Department of Nephrology, International University of Health and Welfare School of Medicine, Narita, Chiba, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4809-5788","authenticated-orcid":false,"given":"Tatsuhiko","family":"Azegami","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Metabolism, and Nephrology, Department of Internal Medicine, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan"},{"name":"Keio University Health Center, Yokohama-shi, Kanagawa, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeshi","family":"Kanda","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Metabolism, and Nephrology, Department of Internal Medicine, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tadashi","family":"Yoshida","sequence":"additional","affiliation":[{"name":"Apheresis and Dialysis Center, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Itoh","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Metabolism, and Nephrology, Department of Internal Medicine, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2022,3,16]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ki.5000251"},{"issue":"2","key":"e_1_3_3_3_2","first-page":"241","article-title":"The impact of pruritus on patients\u2019 quality of life undergoing dialysis: a single-center cohort study","volume":"22","author":"Tessari G","year":"2009","unstructured":"Tessari G, Dalle Vedove C, Loschiavo C, et al. 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