{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T20:38:54Z","timestamp":1777927134395,"version":"3.51.4"},"reference-count":40,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2022,8,9]],"date-time":"2022-08-09T00:00:00Z","timestamp":1660003200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"NIH\/National Center for Advancing Translational Science (NCATS) UCLA CTSI","award":["Grant Number KL2TR000122"],"award-info":[{"award-number":["Grant Number KL2TR000122"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Perit Dial Int"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Peritoneal dialysis (PD) is limited by reduced efficacy over time. We previously showed that a Janus kinase 1\/2 inhibitor (JAK1\/2i) reduced inflammation, hypervascularity and fibrosis induced by 4.25% dextrose dialysate (4.25%D) intraperitoneally (IP) infused for 10 days in rats with normal kidney function. JAK\/STAT signalling mediates inflammatory pathways, including angiotensin signalling. We now tested the effect of long-term JAK1\/2i and\/or an angiotensin receptor blocker (ARB) on peritoneal membrane (PM) in polycystic kidneys (PCK) rats infused with 4.25%D.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      Except for controls, all PCK rats had a tunnelled PD catheter: (1) no infusions; (2) 4.25%D; (3) 4.25%D + JAK1\/2i (5 mg\/kg); (4) 4.25%D +losartan (5 mg\/kg); and (5) 4.25%D + losartan +JAK1\/2i (5 mg\/kg each) IP BID \u00d7 16 weeks ( N = 5\/group). PM VEGFR2 staining areas and submesothelial compact zone (SMCZ) width were morphometrically measured. Peritoneal equilibration testing measured peritoneal ultrafiltration (UF) by calculating dialysate glucose at time 0 and 90 min (D\/D\n                      <jats:sub>0<\/jats:sub>\n                      glucose).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>4.25%D caused hypervascularity, SMCZ widening, fibrosis and UF functional decline in PCK rats. Angiogenesis was significantly attenuated by JAK1\/2i \u00b1 ARB but not by ARB monotherapy. Both treatments reduced SMCZ area. UF was preserved consistently by dual therapy ( p &lt; 0.05) but with inconsistent responses by monotherapies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Long-term JAK1\/2i \u00b1 ARB reduced angiogenesis and fibrosis, and the combination consistently maintained UF. In clinical practice, angiotensin inhibition has been advocated to maintain residual kidney function. Our study suggests that adding JAK1\/2i to angiotensin inhibition may preserve PM structure and UF.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/08968608221116956","type":"journal-article","created":{"date-parts":[[2022,8,10]],"date-time":"2022-08-10T01:42:20Z","timestamp":1660095740000},"page":"159-167","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Dual therapy with an angiotensin receptor blocker and a JAK1\/2 inhibitor attenuates dialysate-induced angiogenesis and preserves peritoneal membrane structure and function in an experimental CKD rat model"],"prefix":"10.1177","volume":"43","author":[{"given":"Pei","family":"Zhang","sequence":"first","affiliation":[{"name":"Division of Nephrology and Hypertension, the Lundquist Institute at Harbor-UCLA Medical Center, Torrance, CA, USA"},{"name":"Department of Nephrology, the First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kana N","family":"Miyata","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Hypertension, the Lundquist Institute at Harbor-UCLA Medical Center, Torrance, CA, USA"},{"name":"Division of Nephrology, Department of Internal Medicine, Saint Louis University, St Louis, MO, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cynthia C","family":"Nast","sequence":"additional","affiliation":[{"name":"Department of Pathology, Cedars-Sinai Medical Center, Los Angeles, CA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janine A","family":"LaPage","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Hypertension, the Lundquist Institute at Harbor-UCLA Medical Center, Torrance, CA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Madisyn","family":"Mahoney","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Hypertension, the Lundquist Institute at Harbor-UCLA Medical Center, Torrance, CA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sonny","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Hypertension, the Lundquist Institute at Harbor-UCLA Medical Center, Torrance, CA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kamran","family":"Khan","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Hypertension, the Lundquist Institute at Harbor-UCLA Medical Center, Torrance, CA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiaoyuan","family":"Wu","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Hypertension, the Lundquist Institute at Harbor-UCLA Medical Center, Torrance, CA, USA"},{"name":"Department of Nephrology, the First Affiliated Hospital, Guangxi Medical University, Nanning, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sharon G","family":"Adler","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Hypertension, the Lundquist Institute at Harbor-UCLA Medical Center, Torrance, CA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7238-3296","authenticated-orcid":false,"given":"Tiane","family":"Dai","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Hypertension, the Lundquist Institute at Harbor-UCLA Medical Center, Torrance, CA, 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