{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T02:47:34Z","timestamp":1790390854819,"version":"4.1.0"},"reference-count":40,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2023,7,5]],"date-time":"2023-07-05T00:00:00Z","timestamp":1688515200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Perit Dial Int"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>Peritoneal dialysis (PD)-related peritonitis is independently associated with low serum 25-hydroxy vitamin D [25(OH)D] levels. Our objective is to examine the feasibility of conducting a large, randomised controlled trial to determine the effects of vitamin D supplementation on the risk of PD-related peritonitis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design:<\/jats:title>\n                    <jats:p>Pilot, prospective, open-label randomised controlled trial.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting:<\/jats:title>\n                    <jats:p>Peking University First Hospital, China.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Participants:<\/jats:title>\n                    <jats:p>Patients receiving PD who had recovered from a recent episode of peritonitis between 30 September 2017 and 28 May 2020.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Interventions:<\/jats:title>\n                    <jats:p>Oral natural vitamin D supplementation (2000 IU per day) versus no vitamin D supplementation for 12 months.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Primary and secondary outcome measures:<\/jats:title>\n                    <jats:p>Primary outcomes were feasibility (recruitment success, retention, adherence, safety) and fidelity (change in serum 25(OH)D level during follow-up) for a large, randomised controlled trial in the future to determine the effects of vitamin D on PD-related peritonitis. Secondary outcomes were time to peritonitis occurrence and outcome of subsequent peritonitis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Overall, 60 among 151 patients were recruited (recruitment rate was 39.7%, 95% CI 31.9\u201347.5%, recruitment rate among eligible patients was 61.9%, 95% CI 52.2\u201371.5%). Retention and adherence rates were 100.0% (95% CI 100.0\u2013100.0%) and 81.5% (95% CI 66.8\u201396.1%), respectively. During follow-up, serum 25(OH)D levels increased in the vitamin D (VD) group (from 19.25 \u00b1 10.11 nmol\/L to 60.27 \u00b1 23.29 nmol\/L after 6 months, p &lt; 0.001, n = 31), and remained higher ( p &lt; 0.001) than those in the control group ( n = 29). No differences were observed between the two groups with respect to time to subsequent peritonitis (hazard ratio 0.85, 95% CI 0.33\u20132.17) or any of the peritonitis outcomes. Adverse events were uncommon.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>A randomised controlled trial of the effect of vitamin D supplementation on peritonitis occurrence in patients receiving PD is feasible, safe and results in adequate serum 25(OH)D levels.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/08968608231182885","type":"journal-article","created":{"date-parts":[[2023,7,6]],"date-time":"2023-07-06T01:59:18Z","timestamp":1688608758000},"page":"27-36","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Oral vitamin D supplementation on the prevention of peritoneal dialysis-related peritonitis: A pilot randomised controlled trial"],"prefix":"10.1177","volume":"44","author":[{"given":"Yu-Hui","family":"Zhang","sequence":"first","affiliation":[{"name":"Renal Division, Department of Medicine, Peking University First Hospital, Beijing, China"},{"name":"Institute of Nephrology, Peking University, Beijing, China"},{"name":"Key Laboratory of Renal Disease, Ministry of Health, Beijing, China"},{"name":"Key Laboratory of Renal Disease, Ministry of Education, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Xu","sequence":"additional","affiliation":[{"name":"Renal Division, Department of Medicine, Peking University First Hospital, Beijing, China"},{"name":"Institute of Nephrology, Peking University, Beijing, China"},{"name":"Key Laboratory of Renal Disease, Ministry of Health, Beijing, China"},{"name":"Key Laboratory of Renal Disease, Ministry of Education, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai-Chen","family":"Pi","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Peking University First Hospital, Beijing, 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