{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T20:39:28Z","timestamp":1777927168155,"version":"3.51.4"},"reference-count":17,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2023,9,25]],"date-time":"2023-09-25T00:00:00Z","timestamp":1695600000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2023,9,25]],"date-time":"2023-09-25T00:00:00Z","timestamp":1695600000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Perit Dial Int"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:p>Vancomycin has been reported to cause vancomycin flushing reaction (VFR), a hypersensitivity reaction that mostly occurs after intravenous administration. The incidence of VFR in a patient receiving intraperitoneal vancomycin is rare. We report a case of a female peritoneal dialysis (PD) patient with a PD-related peritonitis who developed VFR after intraperitoneal administration of 2000 mg vancomycin. Seventy-five minutes after instillation, she developed flushing, a pruritic erythema on the upper body and swelling of the lips. Blood results revealed a vancomycin plasma concentration of 54.8 mg\/L and a normal tryptase level. During a relapse of her PD-related peritonitis, vancomycin was successfully reintroduced in a 50% reduced dose. No symptoms of VFR developed, and the corresponding vancomycin plasma concentration was 33.6 mg\/L. Intraperitoneal treatment was continued with 500 mg vancomycin every 2\u20133 days with frequently measured, adequate trough levels ranging from 15-22 mg\/L. This case illustrates the risk factors for the development of VFR after intraperitoneal administration of vancomycin, namely a high and concentrated loading dose together with a low body weight, a fast peritoneal transport state and peritonitis. Reintroduction of vancomycin after occurrence of VFR is safe, but a lower loading dose or a slower instillation rate is recommended.<\/jats:p>","DOI":"10.1177\/08968608231199735","type":"journal-article","created":{"date-parts":[[2023,9,25]],"date-time":"2023-09-25T03:16:50Z","timestamp":1695611810000},"page":"145-148","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Vancomycin flushing reaction after intraperitoneal vancomycin: A case report"],"prefix":"10.1177","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6496-937X","authenticated-orcid":false,"given":"Julia E","family":"M\u00f6hlmann","sequence":"first","affiliation":[{"name":"Department of Clinical Pharmacy, University Medical Centre Utrecht, University Utrecht, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amely MK","family":"Daza Zabaleta","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Hypertension, University Medical Centre Utrecht, University Utrecht, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthijs","family":"van Luin","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy, University Medical Centre Utrecht, University Utrecht, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alferso C","family":"Abrahams","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Hypertension, University Medical Centre Utrecht, University Utrecht, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2023,9,25]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1177\/08968608221080586"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.3390\/cells10051033"},{"key":"e_1_3_3_4_2","volume-title":"Vancomycin flushing syndrome","author":"Martel TJ","year":"2023","unstructured":"Martel TJ, Jamil RT, King KC. Vancomycin flushing syndrome. Treasure Island, FL: StatPearls Publishing, 2023."},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1177\/106002809402800505"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.12691\/ajmcr-7-1-5"},{"issue":"8","key":"e_1_3_3_7_2","first-page":"e28024","article-title":"Red man syndrome due to oral vancomycin in chronic kidney disease patients: a case report","volume":"14","author":"Yadav S","year":"2022","unstructured":"Yadav S, Hashmi MU, Shah S, et al. Red man syndrome due to oral vancomycin in chronic kidney disease patients: a case report. 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