{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T20:09:47Z","timestamp":1793045387936,"version":"4.5.0"},"reference-count":10,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2024,3,7]],"date-time":"2024-03-07T00:00:00Z","timestamp":1709769600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Perit Dial Int"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>\n                      Periplex\n                      <jats:sup>\u00ae<\/jats:sup>\n                      is a rapid point-of-care test based on the detection of interleukin-6 (IL-6) or matrix metalloproteinase-8 (MMP-8) to diagnose peritonitis in peritoneal dialysis (PD) patients.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>This single-centre study was conducted in Singapore General Hospital from 2019 to 2022. The study recruited PD patients suspected of having peritonitis. Periplex was performed at the presentation and recovery of peritonitis. Primary outcomes were sensitivity and specificity of Periplex at presentation. The positive and negative predictive values of tests were also performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>A total of 120 patients were included in the study. The mean age was 60.9 \u00b1 14.9 years, 53% were male, 79% were Chinese and 47.5% had diabetes mellitus. Periplex was positive in all patients with peritonitis ( n = 114); sensitivity of 100%; 95% confidence interval (CI): 100\u2013100%. Periplex was falsely positive in three patients with non-infective eosinophilic peritonitis, resulting in a low specificity of 50%; 95% CI: 41.1\u201359.0%. Periplex had a positive predictive value of 97.4% and a negative predictive value of 100%. During recovery from peritonitis, Periplex had high specificity (93.6%) and negative predictive value (98.7%) to indicate the resolution of infection. MMP-8 was more sensitive than IL-6 in detecting peritonitis. Periplex was positive in all patients with peritonitis regardless of the types of PD solutions used.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Periplex had high sensitivity, and positive and negative predictive values in the diagnosis of peritonitis can be considered as a screening tool for peritonitis. Given its high specificity and negative predictive value, it may also be used to document the resolution of peritonitis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/08968608241234728","type":"journal-article","created":{"date-parts":[[2024,3,7]],"date-time":"2024-03-07T23:28:20Z","timestamp":1709854100000},"page":"413-418","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Rapid point-of-care test for diagnosis of peritonitis in peritoneal dialysis patients"],"prefix":"10.1177","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6597-7267","authenticated-orcid":false,"given":"Htay","family":"Htay","sequence":"first","affiliation":[{"name":"Department of Renal Medicine, Singapore General Hospital, Singapore, Singapore"},{"name":"DUKE-NUS Medical School, Singapore, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason Chon Jun","family":"Choo","sequence":"additional","affiliation":[{"name":"Department of Renal Medicine, Singapore General Hospital, Singapore, Singapore"},{"name":"DUKE-NUS Medical School, Singapore, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dorothy Hannah","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Renal Medicine, Singapore General Hospital, Singapore, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathini","family":"Jayaballa","sequence":"additional","affiliation":[{"name":"Department of Renal Medicine, Singapore General Hospital, Singapore, Singapore"},{"name":"DUKE-NUS Medical School, Singapore, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5491-3460","authenticated-orcid":false,"given":"David W","family":"Johnson","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Princess Alexandra Hospital, Brisbane, QLD, Australia"},{"name":"Centre for Kidney Disease Research, University of Queensland, Brisbane, QLD, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4456-9592","authenticated-orcid":false,"given":"Riece","family":"Koniman","sequence":"additional","affiliation":[{"name":"Department of Renal Medicine, Singapore General Hospital, Singapore, Singapore"},{"name":"DUKE-NUS Medical School, Singapore, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth Ley","family":"Oei","sequence":"additional","affiliation":[{"name":"Department of Renal Medicine, Singapore General Hospital, Singapore, Singapore"},{"name":"DUKE-NUS Medical School, Singapore, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tan Chieh","family":"Suai","sequence":"additional","affiliation":[{"name":"Department of Renal Medicine, Singapore General Hospital, Singapore, Singapore"},{"name":"DUKE-NUS Medical School, Singapore, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sin Yan","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Renal Medicine, Singapore General Hospital, Singapore, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marjorie Wai Yin","family":"Foo","sequence":"additional","affiliation":[{"name":"Department of Renal Medicine, Singapore General Hospital, Singapore, Singapore"},{"name":"DUKE-NUS Medical School, Singapore, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,3,7]]},"reference":[{"key":"bibr1-08968608241234728","doi-asserted-by":"publisher","DOI":"10.1016\/j.ekir.2016.05.003"},{"key":"bibr2-08968608241234728","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-86071-y"},{"key":"bibr3-08968608241234728","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.09210914"},{"key":"bibr4-08968608241234728","doi-asserted-by":"publisher","DOI":"10.3747\/pdi.2014.00333"},{"key":"bibr5-08968608241234728","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2017.01.017"},{"key":"bibr6-08968608241234728","doi-asserted-by":"publisher","DOI":"10.25796\/bdd.v3i4.57953"},{"key":"bibr7-08968608241234728","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2020.01.044"},{"key":"bibr8-08968608241234728","doi-asserted-by":"crossref","unstructured":"Li PKT, Chow KM, Cho Y, et al. ISPD peritonitis guideline recommendations: 2022 update on prevention and treatment. Perit Dial Int 2022; 42(2): 110\u2013153. Available from: https:\/\/journals.sagepub.com\/doi\/10.1177\/08968608221080586","DOI":"10.1177\/08968608221080586"},{"key":"bibr9-08968608241234728","doi-asserted-by":"publisher","DOI":"10.3747\/pdi.2018.00056"},{"key":"bibr10-08968608241234728","doi-asserted-by":"publisher","DOI":"10.3904\/kjim.2004.19.2.121"}],"container-title":["Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/08968608241234728","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/08968608241234728","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/08968608241234728","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T22:37:07Z","timestamp":1777675027000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/08968608241234728"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,7]]},"references-count":10,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2024,11]]}},"alternative-id":["10.1177\/08968608241234728"],"URL":"https:\/\/doi.org\/10.1177\/08968608241234728","relation":{},"ISSN":["0896-8608","1718-4304"],"issn-type":[{"value":"0896-8608","type":"print"},{"value":"1718-4304","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,3,7]]}}}