{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T02:47:33Z","timestamp":1790390853438,"version":"4.1.0"},"reference-count":39,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2024,3,19]],"date-time":"2024-03-19T00:00:00Z","timestamp":1710806400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Perit Dial Int"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Mineral bone disorder (MBD) in chronic kidney disease (CKD) is associated with high symptom burden, fractures, vascular calcification, cardiovascular disease and increased morbidity and mortality. CKD-MBD studies have been limited in peritoneal dialysis (PD) patients. Here, we describe calcium and parathyroid hormone (PTH) control, related treatments and mortality associations in PD patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      We used data from eight countries (Australia and New Zealand (A\/NZ), Canada, Japan, Thailand, South Korea, United Kingdom, United States (US)) participating in the prospective cohort Peritoneal Dialysis Outcomes and Practice Patterns Study (2014\u20132022) among patients receiving PD for &gt;3 months. We analysed the association of baseline PTH and albumin-adjusted calcium (calcium\n                      <jats:sup>Alb<\/jats:sup>\n                      ) with all-cause mortality using Cox regression, adjusted for potential confounders, including serum phosphorus and alkaline phosphatase.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Mean age ranged from 54.6 years in South Korea to 63.5 years in Japan. PTH and serum calcium\n                      <jats:sup>Alb<\/jats:sup>\n                      were measured at baseline in 12,642 and 14,244 patients, respectively. Median PTH ranged from 161 (Japan) to 363 pg\/mL (US); mean calcium\n                      <jats:sup>Alb<\/jats:sup>\n                      ranged from 9.1 (South Korea, US) to 9.8 mg\/dL (A\/NZ). The PTH\/mortality relationship was U-shaped, with the lowest risk at PTH 300\u2013599 pg\/mL. Mortality was nearly 20% higher at serum calcium\n                      <jats:sup>Alb<\/jats:sup>\n                      9.6+ mg\/dL versus 8.4\u2013&lt;9.6 mg\/dL. MBD therapy prescriptions varied substantially across countries.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>A large proportion of PD patients in this multi-national study have calcium and\/or PTH levels in ranges associated with substantially higher mortality. These observations point to the need to substantially improve MBD management in PD to optimise patient outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Lay Summary<\/jats:title>\n                    <jats:p>Chronic kidney disease-mineral bone disorder (MBD) is a systemic condition, common in dialysis patients, that results in abnormalities in parathyroid hormone (PTH), calcium, phosphorus and vitamin D metabolism. A large proportion of peritoneal dialysis (PD) patients in this current multi-national study had calcium and\/or PTH levels in ranges associated with substantially higher risks of death. Our observational study design limits our ability to determine whether these abnormal calcium and PTH levels cause more death due to possible confounding that was not accounted for in our analysis. However, our findings, along with other recent work showing 48\u201375% higher risk of death for the one-third of PD patients having high phosphorus levels (&gt;5.5 mg\/dL), should raise strong concerns for a greater focus on improving MBD management in PD patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/08968608241235516","type":"journal-article","created":{"date-parts":[[2024,3,19]],"date-time":"2024-03-19T03:43:48Z","timestamp":1710819828000},"page":"275-286","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["International variations in serum PTH and calcium levels and their mortality associations in peritoneal dialysis patients: Results from PDOPPS"],"prefix":"10.1177","volume":"44","author":[{"given":"Kosaku","family":"Nitta","sequence":"first","affiliation":[{"name":"Department of Nephrology, Tokyo Women\u2019s Medical University, Shinjuku, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Bieber","sequence":"additional","affiliation":[{"name":"Arbor Research Collaborative for Health, Ann Arbor, MI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelo","family":"Karaboyas","sequence":"additional","affiliation":[{"name":"Arbor Research Collaborative for Health, Ann Arbor, MI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5491-3460","authenticated-orcid":false,"given":"David W","family":"Johnson","sequence":"additional","affiliation":[{"name":"Australasian Kidney Trials Network, University of Queensland, Brisbane, Australia"},{"name":"Department of Kidney and Transplant Services, Princess Alexandra, Brisbane, Australia"},{"name":"Translational Research Institute, Brisbane, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2996-8934","authenticated-orcid":false,"given":"Talerngsak","family":"Kanjanabuch","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Medicine and Center of Excellence in Kidney Metabolic Disorders and Dialysis Policy & Practice Program (DiP3), School of Global Health, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong-Lim","family":"Kim","sequence":"additional","affiliation":[{"name":"School of Medicine, Kyungpook National University, Daegu, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Lambie","sequence":"additional","affiliation":[{"name":"Medicine and Health Sciences, Keele University, Keele, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Hartman","sequence":"additional","affiliation":[{"name":"Visonex, Green Bay, WI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2993-403X","authenticated-orcid":false,"given":"Jenny I","family":"Shen","sequence":"additional","affiliation":[{"name":"The Lundquist Institute at Harbor-University of California, Los Angeles Medical Center, Torrance, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mihran","family":"Naljayan","sequence":"additional","affiliation":[{"name":"Home Modalities, DaVita Kidney Care, Denver, CO, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Pecoits-Filho","sequence":"additional","affiliation":[{"name":"Arbor Research Collaborative for Health, Ann Arbor, MI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce M","family":"Robinson","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald L","family":"Pisoni","sequence":"additional","affiliation":[{"name":"Arbor Research Collaborative for Health, Ann Arbor, MI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey","family":"Perl","sequence":"additional","affiliation":[{"name":"Division of Nephrology, St. Michael\u2019s Hospital and the Keenan Research Center in the Li Ka Shing Knowledge Institute, St. Michael\u2019s Hospital, University of Toronto, Toronto, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideki","family":"Kawanishi","sequence":"additional","affiliation":[{"name":"Akane Foundation, Tsuchiya General Hospital, Nakaku, Hiroshima, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,3,19]]},"reference":[{"issue":"113","key":"bibr1-08968608241235516","first-page":"S1","volume":"76","author":"Kidney Disease: Improving Global Outcomes (KDIGO) CKD-MBD Work Group","year":"2009","journal-title":"Kidney Int"},{"key":"bibr2-08968608241235516","doi-asserted-by":"publisher","DOI":"10.1177\/089686080402400302"},{"issue":"4","key":"bibr3-08968608241235516","first-page":"S1","volume":"42","author":"K\/DOQI clinical practice guidelines for bone metabolism and disease in chronic kidney disease","year":"2003","journal-title":"Am J Kidney Dis"},{"key":"bibr4-08968608241235516","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2017.04.006"},{"key":"bibr5-08968608241235516","doi-asserted-by":"publisher","DOI":"10.3747\/pdi.2014.00279"},{"key":"bibr6-08968608241235516","doi-asserted-by":"publisher","DOI":"10.1111\/1744-9987.12058"},{"key":"bibr7-08968608241235516","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfs404"},{"key":"bibr8-08968608241235516","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfq219"},{"key":"bibr9-08968608241235516","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2008.03.020"},{"key":"bibr10-08968608241235516","doi-asserted-by":"publisher","DOI":"10.3747\/pdi.2014.00288"},{"key":"bibr11-08968608241235516","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfac249"},{"key":"bibr12-08968608241235516","unstructured":"Raghunathan TE, Solenberger PW, Berglund J, et al. IVEware: Imputation and variance estimation software. Survey methodology program, survey research center, institute for social research, university of Michigan. https:\/\/www.src.isr.umich.edu\/software\/. 2002."},{"key":"bibr13-08968608241235516","doi-asserted-by":"publisher","DOI":"10.1002\/9780470316696"},{"key":"bibr14-08968608241235516","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1103313"},{"key":"bibr15-08968608241235516","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2012.07.008"},{"key":"bibr16-08968608241235516","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2021.02.327"},{"key":"bibr17-08968608241235516","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.03530410"},{"key":"bibr18-08968608241235516","doi-asserted-by":"publisher","DOI":"10.1053\/j.jrn.2013.01.018"},{"key":"bibr19-08968608241235516","doi-asserted-by":"publisher","DOI":"10.1159\/000521508"},{"key":"bibr20-08968608241235516","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.12941213"},{"key":"bibr21-08968608241235516","doi-asserted-by":"publisher","DOI":"10.1177\/0896860819895356"},{"key":"bibr22-08968608241235516","doi-asserted-by":"publisher","DOI":"10.3747\/pdi.2013.00110"},{"key":"bibr23-08968608241235516","doi-asserted-by":"publisher","DOI":"10.1590\/2175-8239-jbn-2020-0040"},{"key":"bibr24-08968608241235516","doi-asserted-by":"publisher","DOI":"10.1177\/0896860820918131"},{"key":"bibr25-08968608241235516","doi-asserted-by":"publisher","DOI":"10.1080\/0886022X.2022.2041438"},{"key":"bibr26-08968608241235516","doi-asserted-by":"publisher","DOI":"10.1053\/ajkd.2001.29254"},{"key":"bibr27-08968608241235516","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2021.04.043"},{"key":"bibr28-08968608241235516","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0174811"},{"key":"bibr29-08968608241235516","doi-asserted-by":"publisher","DOI":"10.1590\/S0101-28002010000300009"},{"key":"bibr30-08968608241235516","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-00080-4"},{"key":"bibr31-08968608241235516","doi-asserted-by":"publisher","DOI":"10.1177\/089686080202200207"},{"key":"bibr32-08968608241235516","doi-asserted-by":"publisher","DOI":"10.34172\/jrip.2021.36"},{"key":"bibr33-08968608241235516","doi-asserted-by":"publisher","DOI":"10.34067\/KID.0000772020"},{"key":"bibr34-08968608241235516","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.11931116"},{"key":"bibr35-08968608241235516","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2014050472"},{"key":"bibr36-08968608241235516","doi-asserted-by":"publisher","DOI":"10.1159\/000319861"},{"key":"bibr37-08968608241235516","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2369-14-88"},{"key":"bibr38-08968608241235516","doi-asserted-by":"publisher","DOI":"10.7326\/M17-2640"},{"key":"bibr39-08968608241235516","doi-asserted-by":"publisher","DOI":"10.1186\/s12882-019-1388-9"}],"container-title":["Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/08968608241235516","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/08968608241235516","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/08968608241235516","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T22:37:07Z","timestamp":1777675027000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/08968608241235516"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,19]]},"references-count":39,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,7]]}},"alternative-id":["10.1177\/08968608241235516"],"URL":"https:\/\/doi.org\/10.1177\/08968608241235516","relation":{},"ISSN":["0896-8608","1718-4304"],"issn-type":[{"value":"0896-8608","type":"print"},{"value":"1718-4304","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,3,19]]}}}