{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T20:39:47Z","timestamp":1777927187279,"version":"3.51.4"},"reference-count":16,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2024,4,26]],"date-time":"2024-04-26T00:00:00Z","timestamp":1714089600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Perit Dial Int"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:p>\n                    Currently, pharmacokinetic information on intravenous (IV) piperacillin\/tazobactam in patients with peritoneal dialysis-associated peritonitis (PD peritonitis) is limited. This study employed a prospective single-dose pharmacokinetic design to assess the pharmacokinetics of IV piperacillin\/tazobactam in these patients. Four patients with PD peritonitis who received an IV loading dose of 4000 mg\/500 mg piperacillin\/tazobactam were enrolled in this study. The concentrations of piperacillin and tazobactam in plasma, peritoneal dialysis fluid (PDF) and urine were determined by high-performance liquid chromatography. Non-compartmental methods were used for pharmacokinetic analysis. During a 6-h dwell time for chronic ambulatory peritoneal dialysis (CAPD), 9.23 \u00b1 4.01% of the piperacillin was recovered in the PDF. This result is greater than that observed in patients without peritonitis in prior research. Piperacillin\u2019s PD clearance (CL\n                    <jats:sub>PD<\/jats:sub>\n                    ), steady-state volume of distribution ( Vss) and terminal half-life ( t\n                    <jats:sub>1\/2<\/jats:sub>\n                    ) were 5.79 \u00b1 2.55 mL\/min, 24.35 \u00b1 11.26 L and 5.74 \u00b1 1.53 h, respectively. These values are also higher than those of patients without peritonitis in a prior study. Eight hours following the loading dosage, the plasma and PDF piperacillin concentrations of all patients (98.25 \u00b1 26.03 and 52.70 \u00b1 22.99 mg\/L, respectively) surpassed the Pseudomonas aeruginosa and Enterobacterales Clinical and Laboratory Standards Institute susceptible breakpoints. In summary, the CL\n                    <jats:sub>PD<\/jats:sub>\n                    , Vss and t\n                    <jats:sub>1\/2<\/jats:sub>\n                    for piperacillin were found to be greater in patients with PD peritonitis than in CAPD patients without peritonitis when compared with the results of a previous study. The IV loading dose of 4000 mg\/500 mg piperacillin\/tazobactam is sufficient to treat peritonitis caused by susceptible P. aeruginosa and Enterobacterales. The multiple-dose pharmacokinetics of IV piperacillin and tazobactam in this specific patient group should be further investigated.\n                  <\/jats:p>","DOI":"10.1177\/08968608241241449","type":"journal-article","created":{"date-parts":[[2024,4,26]],"date-time":"2024-04-26T08:11:10Z","timestamp":1714119070000},"page":"57-61","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Pharmacokinetics of intravenous piperacillin\/tazobactam among patients with peritoneal dialysis-associated peritonitis"],"prefix":"10.1177","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7636-1660","authenticated-orcid":false,"given":"Taweesak","family":"Maneerot","sequence":"first","affiliation":[{"name":"The College of Pharmacotherapy of Thailand, The Pharmacy Council, Nonthaburi, Thailand"},{"name":"Department of Clinical Pharmacy, Faculty of Pharmaceutical Sciences, Prince of Songkla University, Songkhla, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suwikran","family":"Wongpraphairot","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Internal Medicine, Faculty of Medicine, Prince of Songkla University, Songkhla, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aroonrut","family":"Lucksiri","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Care, Faculty of Pharmacy, Chiang Mai University, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sutep","family":"Jaruratanasirikul","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Prince of Songkla University, Songkhla, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3781-5062","authenticated-orcid":false,"given":"Weerachai","family":"Chaijamorn","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy, Siam University, Bangkok, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nanthawut","family":"Ninwisut","sequence":"additional","affiliation":[{"name":"Nephrology Unit, Songkhla Hospital, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Uraiwan","family":"Parinyasiri","sequence":"additional","affiliation":[{"name":"Nephrology Unit, Songkhla Hospital, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuttitham","family":"Suteeka","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Faculty of Medicine, Chiang Mai University, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sutthiporn","family":"Pattharachayakul","sequence":"additional","affiliation":[{"name":"The College of Pharmacotherapy of Thailand, The Pharmacy Council, Nonthaburi, Thailand"},{"name":"Department of Clinical Pharmacy, Faculty of Pharmaceutical Sciences, Prince of Songkla University, Songkhla, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2024,4,26]]},"reference":[{"key":"bibr1-08968608241241449","doi-asserted-by":"publisher","DOI":"10.1177\/08968608221080586"},{"key":"bibr2-08968608241241449","doi-asserted-by":"publisher","DOI":"10.1016\/j.xkme.2020.04.010"},{"key":"bibr3-08968608241241449","doi-asserted-by":"publisher","DOI":"10.1177\/089686080002000619"},{"key":"bibr4-08968608241241449","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.V1161117"},{"key":"bibr5-08968608241241449","doi-asserted-by":"publisher","DOI":"10.2147\/IJNRD.S123618"},{"key":"bibr6-08968608241241449","doi-asserted-by":"publisher","DOI":"10.3747\/pdi.2013.00012"},{"key":"bibr7-08968608241241449","doi-asserted-by":"publisher","DOI":"10.1177\/089686080002000211"},{"key":"bibr8-08968608241241449","doi-asserted-by":"publisher","DOI":"10.1002\/jps.2600790204"},{"key":"bibr9-08968608241241449","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.1992.5"},{"key":"bibr10-08968608241241449","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-4347(00)82563-3"},{"key":"bibr11-08968608241241449","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.1981.tb01304.x"},{"key":"bibr12-08968608241241449","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro862"},{"key":"bibr13-08968608241241449","doi-asserted-by":"publisher","DOI":"10.1517\/17425255.2010.506187"},{"key":"bibr14-08968608241241449","volume-title":"Performance 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