{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T13:25:32Z","timestamp":1787059532725,"version":"build-2736575974"},"reference-count":22,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2024,10,15]],"date-time":"2024-10-15T00:00:00Z","timestamp":1728950400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2024,10,15]],"date-time":"2024-10-15T00:00:00Z","timestamp":1728950400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Perit Dial Int"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The stability of antimicrobials in peritonitis during peritoneal dialysis (PD) solutions is a critical factor influencing treatment success. This study investigated the stability of daptomycin (DAP) when combined with icodextrin-based PD solution, by measuring DAP concentrations and observing any structural changes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A dose of DAP (350\u2005mg) was dissolved in 7\u2005mL of saline in a clean bench. The solution was then injected into the large compartment (1,260\u2005mL) of NICOPELIQ\n                      <jats:sup>\u00ae<\/jats:sup>\n                      Peritoneal Dialysis Solution and thoroughly mixed. Samples were collected at intervals ranging from 0 to 336\u2005h (7 points in total). The concentration of DAP was quantified using high-performance liquid chromatography (HPLC). The structure of any unidentified peaks was determined using HPLC coupled with electrospray ionization tandem mass spectrometry.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      DAP maintained 90% of the initial concentration in NICOPELIC\n                      <jats:sup>\u00ae<\/jats:sup>\n                      for 72\u2005h at room temperature and 12\u2005h at 37\u2005\u00b0C. Unidentified peaks, distinct from DAP, were detected during analysis. Further investigation indicated that these peaks corresponded to anhydrated DAP.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The findings from this stability study are expected to enhance the effectiveness of outpatient management and preparation for treating peritonitis using DAP.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/08968608241283526","type":"journal-article","created":{"date-parts":[[2024,10,15]],"date-time":"2024-10-15T07:08:10Z","timestamp":1728976090000},"page":"353-358","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Assessing the stability of daptomycin in icodextrin-based peritoneal dialysis solution"],"prefix":"10.1177","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6970-8160","authenticated-orcid":false,"given":"Hiroyuki","family":"Suzuki","sequence":"first","affiliation":[{"name":"Tohoku Medical and Pharmaceutical University"},{"name":"Tohoku Medical and Pharmaceutical University Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kasumi","family":"Kudo","sequence":"additional","affiliation":[{"name":"Tohoku Medical and Pharmaceutical University Hospital"},{"name":"Tohoku Medical and Pharmaceutical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Uno","sequence":"additional","affiliation":[{"name":"Tohoku Medical and Pharmaceutical University Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taisuke","family":"Konno","sequence":"additional","affiliation":[{"name":"Tohoku Medical and Pharmaceutical University"},{"name":"Tohoku Medical and Pharmaceutical University Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kouji","family":"Okada","sequence":"additional","affiliation":[{"name":"Tohoku Medical and Pharmaceutical University Hospital"},{"name":"Tohoku Medical and Pharmaceutical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuyuki","family":"Agatsuma","sequence":"additional","affiliation":[{"name":"Tohoku Medical and Pharmaceutical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hitoshi","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Tohoku Medical and Pharmaceutical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuriko","family":"Murai","sequence":"additional","affiliation":[{"name":"Tohoku Medical and Pharmaceutical 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