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However, PD technique failure due to loss of residual kidney function and\/or loss of peritoneal membrane function may require patients to transition to HD, where hybrid dialysis (combining PD and HD) may be a viable alternative to thrice-weekly HD, while also promoting patient-centered care. However, hybrid dialysis is not advocated in current clinical practice guidelines, potentially due to a lack of clinician experience or high certainty evidence on the benefits, safety, and cost of combining PD and HD. In this narrative review, we summarize the existing data on health and economic outcomes in patients transitioning from PD alone to combined PD and HD, which may inform patient selection, dialysis prescription, and evaluation of dialysis quality for clinicians and patients considering hybrid dialysis.<\/jats:p>","DOI":"10.1177\/08968608251395132","type":"journal-article","created":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T17:43:29Z","timestamp":1762883009000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Hybrid dialysis: Two modalities twice the benefit?"],"prefix":"10.1177","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6897-2231","authenticated-orcid":false,"given":"Edmund YM","family":"Chung","sequence":"first","affiliation":[{"name":"The Children's Hospital at Westmead"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7648-007X","authenticated-orcid":false,"given":"Kamal","family":"Sud","sequence":"additional","affiliation":[{"name":"Nepean Hospital"},{"name":"Nepean Clinical School, The University of Sydney, Sydney, Australia, NSW, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,11,11]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.01220406"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.291.6.697"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gft214"},{"key":"e_1_3_3_5_2","volume-title":"47th Report, Chapter 5: Peritoneal dialysis","author":"Chen J","year":"2024","unstructured":"Chen J, Davies C, Au E, et al. 47th Report, Chapter 5: Peritoneal dialysis. 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