{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T08:10:20Z","timestamp":1793261420501,"version":"4.5.0"},"reference-count":49,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T00:00:00Z","timestamp":1772928000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100010564","name":"Academic Medical Organization of Southwestern Ontario","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100010564","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Perit Dial Int"],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Maintaining neurocognitive function is essential in the care of patients requiring dialysis. Currently, it is known that intradialytic systemic injury occurs during hemodialysis (HD) leading to ischemic injury and subcortical abnormalities that correspond to neurocognitive impairments. However, the pathophysiology of the intradialytic effects of peritoneal dialysis (PD) on the brain and neurocognitive function is unknown.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Patients completed a neurocognitive battery (The Montreal Cognitive Assessment [MoCA], Trails Making Test [TMT], and Cambridge Brain Science [CBS]), a diffusion tensor imaging scan, and proton magnetic resonance spectroscopy (\n                      <jats:sup>1<\/jats:sup>\n                      H-MRS). Imaging and neurocognitive assessments were performed before PD exchange, with repeat imaging after 90\u2005min of dwell time.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Twelve patients receiving PD were studied. Patient demographics included (mean\u2009\u00b1\u2009SD): 67\u2009\u00b1\u20098 years, 75% male, 75% diabetic, with a dialysis vintage of 18\u2009\u00b1\u20099 months. Intradialytic\n                      <jats:sup>1<\/jats:sup>\n                      H-MRS detected a 21% increase in glucose after 90\u2005min (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.006); however, no acute white matter effects were evident. The neurocognitive battery indicated that most impairment was seen on the TMT A\/B (92%\/50% impaired), indicating impairments in attention and executive function. Four CBS tasks showed impairment representing verbal, short-term memory, and reasoning impairments. Finally, 17% of the cohort was impaired on the MoCA.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study demonstrated that PD is not associated with the same acute intradialytic ischemic injury routinely experienced by patients receiving HD, which may indicate that PD has a neuro-hemodynamic protective effect. However, those receiving PD did experience metabolic stress in the form of significant cerebral hyperglycemia, which may precipitate neurocognitive impairments indicating further investigation is warranted.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/08968608261421102","type":"journal-article","created":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T10:16:39Z","timestamp":1773224199000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Peritoneal dialysis patients exhibit cognitive deficits but not ischemic brain injury: A magnetic resonance spectroscopy &amp; diffusion tensor imaging study"],"prefix":"10.1177","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4167-8697","authenticated-orcid":false,"given":"Jessica A.","family":"Vanderlinden","sequence":"first","affiliation":[{"name":"Western University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4584-7251","authenticated-orcid":false,"given":"Dickson","family":"Wong","sequence":"additional","affiliation":[{"name":"Schulich School of Medicine and Dentistry, Western University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Chiu","sequence":"additional","affiliation":[{"name":"Lawson Health Research Institute"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"McIntyre","sequence":"additional","affiliation":[{"name":"Western University"},{"name":"Schulich School of Medicine and Dentistry, Western University"},{"name":"Lawson Health Research Institute"},{"name":"London Health Sciences Centre"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arsh K.","family":"Jain","sequence":"additional","affiliation":[{"name":"Schulich School of Medicine and Dentistry, Western University"},{"name":"Lawson Health Research Institute"},{"name":"London Health Sciences Centre"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,3,8]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.02660310"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10157-019-01762-1"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2010.11.026"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.3747\/pdi.2014.00213"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2003.12.031"},{"issue":"6","key":"e_1_3_3_7_2","article-title":"The comparison of cognitive function and risk of dementia in CKD patients under peritoneal dialysis and hemodialysis: A PRISMA-compliant systematic review and meta-analysis","volume":"98","author":"Tian X","year":"2019","unstructured":"Tian X, et al. 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