{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T12:45:00Z","timestamp":1791809100679,"version":"4.3.4"},"reference-count":15,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T00:00:00Z","timestamp":1779753600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100010230","name":"Queensland Health","doi-asserted-by":"publisher","award":["Queensland Advancing Clinical Research Fellowship"],"award-info":[{"award-number":["Queensland Advancing Clinical Research Fellowship"]}],"id":[{"id":"10.13039\/100010230","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009844","name":"PA Research Foundation","doi-asserted-by":"publisher","award":["Renal Tied Fund"],"award-info":[{"award-number":["Renal Tied Fund"]}],"id":[{"id":"10.13039\/100009844","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Perit Dial Int"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Patients receiving peritoneal dialysis (PD) often report problems with constipation. Constipation in PD is associated with increased risks of mechanical and infectious complications, such as poor drainage and fluid removal, catheter migration and peritonitis. A natural fibre supplement, psyllium husk, has been identified as a potential alternative therapy to minimise the risk of constipation for patients receiving PD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      FIBRE-PD is a prospective parallel-arm open-label feasibility study in which patients on PD were 1:1 randomly assigned to receive either psyllium husk (intervention group) or continue routine Movicol\n                      <jats:sup>\u00ae<\/jats:sup>\n                      (control group) for four weeks (28 days). The primary outcome was feasibility, defined as successful recruitment of 60 patients, representing 70% of eligible PD patients. Secondary outcomes included adherence, retention, safety, bowel frequency and patient-reported outcomes (e.g., gastrointestinal symptom burden, quality of life).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Overall, 96 patients were screened for eligibility. Sixty-six (69%) were deemed not eligible, mainly due to non-adherence to prescribed regular Movicol (\n                      <jats:italic toggle=\"yes\">n\u2009=\u2009<\/jats:italic>\n                      41, 62%). Among 30 eligible patients, 20 patients (67% of eligible population) were successfully recruited into the study. The intervention group demonstrated high retention (77%), adherence rates (78%) and significant improvement in gastrointestinal symptoms and quality of life compared to patients in the control group. No adverse outcomes were reported.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The FIBRE-PD did not meet its original recruitment target due to an unexpectedly high number of ineligible patients. The recruited proportion almost reached the pre-specified target of 70% of eligible patients, and participants in the intervention group demonstrated high retention and adherence rates with observed benefits in gastrointestinal symptom burden and quality of life.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/08968608261429654","type":"journal-article","created":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T12:46:31Z","timestamp":1779799591000},"page":"510-517","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Pilot randomised controlled trial evaluating feasibility, safety and adherence to psyllium husk in peritoneal dialysis: The FIBRE-PD trial"],"prefix":"10.1177","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-5506-4132","authenticated-orcid":false,"given":"Chloe","family":"Howard","sequence":"first","affiliation":[{"name":"Princess Alexandra Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5491-3460","authenticated-orcid":false,"given":"David W","family":"Johnson","sequence":"additional","affiliation":[{"name":"Princess Alexandra Hospital"},{"name":"Australasian Kidney Trials Network at the Faculty of Health, Medicine and Behavioural Science at the University of Queensland, Brisbane, QLD, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmel M","family":"Hawley","sequence":"additional","affiliation":[{"name":"Princess Alexandra Hospital"},{"name":"Australasian Kidney Trials Network at the Faculty of Health, Medicine and Behavioural Science at the University of Queensland, Brisbane, QLD, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kylie","family":"Pegg","sequence":"additional","affiliation":[{"name":"Princess Alexandra Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannah","family":"Mayr","sequence":"additional","affiliation":[{"name":"Princess Alexandra Hospital"},{"name":"Greater Brisbane Clinical School, Faculty of Health, Medicine and Behavioural Science, the University of Queensland, Brisbane, QLD, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana","family":"Leary","sequence":"additional","affiliation":[{"name":"Princess Alexandra Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachael","family":"Hale","sequence":"additional","affiliation":[{"name":"Princess Alexandra Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea K","family":"Viecelli","sequence":"additional","affiliation":[{"name":"Australasian Kidney Trials Network at the Faculty of Health, Medicine and Behavioural Science at the University of Queensland, Brisbane, QLD, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janette","family":"Hamilton","sequence":"additional","affiliation":[{"name":"Princess Alexandra Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vicki","family":"Thomas","sequence":"additional","affiliation":[{"name":"Princess Alexandra Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irish","family":"Dela-Pena","sequence":"additional","affiliation":[{"name":"Princess Alexandra Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3502-9837","authenticated-orcid":false,"given":"Yeoungjee","family":"Cho","sequence":"additional","affiliation":[{"name":"Princess Alexandra Hospital"},{"name":"Australasian Kidney Trials Network at the Faculty of Health, Medicine and Behavioural Science at the University of Queensland, Brisbane, QLD, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,5,26]]},"reference":[{"key":"e_1_3_3_2_2","unstructured":"ANZDATA. 43rd Annual Report 2020 (Data to 2019) \u2013 anzdata.org.au."},{"key":"e_1_3_3_3_2","doi-asserted-by":"crossref","unstructured":"Kosmadakis G Albaret J Da Costa Correia E et al. Constipation in peritoneal dialysis patients. Perit Dial Int 2019; 39: 399\u2013404.","DOI":"10.3747\/pdi.2018.00169"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.5414\/CN107249"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ekir.2019.11.002"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.05380518"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/jorc.12056"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/JXX.0000000000000346"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctim.2018.07.004"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1080\/19490976.2023.2197837"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.5152\/tjg.2020.20229"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2431-12-178"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1177\/08968608251361298"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2017.10.019"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1177\/08968608221126849"},{"key":"e_1_3_3_16_2","first-page":"441","article-title":"Managing the symptom burden associated with maintenance dialysis: conclusions from a kidney disease: improving global outcomes (KDIGO)","volume":"104","author":"Mehrotra R, Davison SN, Farrington K, et al.","year":"2023","unstructured":"Mehrotra R, Davison SN, Farrington K, et al. Managing the symptom burden associated with maintenance dialysis: conclusions from a kidney disease: improving global outcomes (KDIGO). Controvers Conf. Kidney Int 2023; 104: 441\u2013454.","journal-title":"Controvers Conf. 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