{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T20:41:06Z","timestamp":1777927266305,"version":"3.51.4"},"reference-count":16,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T00:00:00Z","timestamp":1773619200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Perit Dial Int"],"abstract":"<jats:p>\n                    Nontuberculous mycobacteria are rare but serious pathogens in peritoneal dialysis (PD)-associated infections.\n                    <jats:italic toggle=\"yes\">Mycobacterium abscessus (M. abscessus<\/jats:italic>\n                    ) is usually resistant to standard anti-tuberculosis drugs. Macrolide antibiotics are key drugs for treating\n                    <jats:italic toggle=\"yes\">M. abscessus<\/jats:italic>\n                    , but macrolide-resistant strains pose particular challenges, and an optimal antimicrobial treatment strategy or duration has not been established for\n                    <jats:italic toggle=\"yes\">M. abscessus<\/jats:italic>\n                    PD-associated infections. We report a case of a 63-year-old man on PD who developed persistent purulent discharge from his PD catheter exit site. Skin swab culture identified macrolide-resistant\n                    <jats:italic toggle=\"yes\">M. abscessus,<\/jats:italic>\n                    with imaging confirming inflammation along the catheter tunnel. These findings led to the diagnosis of\n                    <jats:italic toggle=\"yes\">M. abscessus<\/jats:italic>\n                    PD catheter tunnel infection, with peritonitis excluded. Initial management included early catheter removal, extensive surgical debridement, and 6 weeks of combination antibiotic therapy, including imipenem\u2013cilastatin, amikacin, and clarithromycin, achieving clinical cure. However, the infection recurred after 5 months, necessitating retreatment with debridement and an antibiotic regimen including imipenem\u2013cilastatin, amikacin, azithromycin, and clofazimine for 4 weeks, followed by a continuation regimen with amikacin, clofazimine, and sitafloxacin for 4 months. This approach achieved sustained clinical cure without recurrence at 14 months of follow-up. Based on a literature review of 67 cases of\n                    <jats:italic toggle=\"yes\">M. abscessus<\/jats:italic>\n                    PD-associated infections, all six cases treated with clofazimine achieved clinical cure, but there were no reports on cases of macrolide-resistant\n                    <jats:italic toggle=\"yes\">M. abscessus<\/jats:italic>\n                    treated with clofazimine. Our case represents the first successful clofazimine treatment of macrolide-resistant\n                    <jats:italic toggle=\"yes\">M. abscessus<\/jats:italic>\n                    PD-associated infection, demonstrating clofazimine as a potentially effective oral antibiotic option in combination therapy, particularly in macrolide-resistant cases with limited therapeutic options.\n                  <\/jats:p>","DOI":"10.1177\/08968608261432158","type":"journal-article","created":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T09:01:16Z","timestamp":1773651676000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Successful treatment with clofazimine for macrolide-resistant\n                    <i>Mycobacterium abscessus<\/i>\n                    infection in a peritoneal dialysis patient: A case report and literature review"],"prefix":"10.1177","author":[{"given":"Mizuki","family":"Kimura","sequence":"first","affiliation":[{"name":"Hokkaido University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8760-8630","authenticated-orcid":false,"given":"Kanako","family":"Watanabe-Kusunoki","sequence":"additional","affiliation":[{"name":"Hokkaido University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mina","family":"Eguchi","sequence":"additional","affiliation":[{"name":"Hokkaido University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fumihiko","family":"Hattanda","sequence":"additional","affiliation":[{"name":"Hokkaido University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daigo","family":"Nakazawa","sequence":"additional","affiliation":[{"name":"Hokkaido University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saori","family":"Nishio","sequence":"additional","affiliation":[{"name":"Hokkaido University Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takayuki","family":"Hirose","sequence":"additional","affiliation":[{"name":"Hokkaido University Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keisuke","family":"Kamada","sequence":"additional","affiliation":[{"name":"Hokkaido University"},{"name":"Japan Anti-Tuberculosis Association"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatsuya","family":"Atsumi","sequence":"additional","affiliation":[{"name":"Hokkaido University"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2026,3,16]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfr504"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00535-2020"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12882-024-03841-2"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.3747\/pdi.2011.00184"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2007.04.017"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200604-571ST"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2023.1100488"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jgar.2021.06.002"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02234-18"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00544-18"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkae041"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01505-12"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1128\/aac.01579-22"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1177\/0896860820909702"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.47102\/annals-acadmedsg.2021228"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciu444"}],"container-title":["Peritoneal 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