{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T08:09:01Z","timestamp":1778486941854,"version":"3.51.4"},"reference-count":45,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T00:00:00Z","timestamp":1778198400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T00:00:00Z","timestamp":1778198400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Perit Dial Int"],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The choice of kidney replacement therapy (KRT) modality for treatment of dialysis requiring acute kidney injury (AKI-D) is underappreciated as a modifiable factor that can impact outcomes. Peritoneal dialysis (PD) and extracorporeal dialysis are both established modalities for treatment of kidney failure; their comparative effectiveness in AKI remains controversial. We conducted a systematic review and meta-analysis to compare clinical outcomes between PD and extracorporeal dialysis in patients with AKI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We systematically searched Medline, Embase, and Cochrane Central Register of Controlled Trials from inception through November 2024 for randomized controlled trials comparing PD with extracorporeal dialysis in adult patients with AKI requiring KRT. The primary outcome was mortality. Secondary outcomes included kidney function recovery, time to kidney function recovery, and infectious complications. We conducted meta-analyses using random-effects models and assessed risk of bias using the Cochrane Risk of Bias tool 2.0.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      About 358 records were identified, of which 7 were included in quantitative meta-analysis. We found no significant difference in mortality between PD and extracorporeal dialysis (odds ratio [OR] 1.05; 95% confidence interval [CI], 0.62\u20131.76;\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.87). Event rates were similar between groups (PD: 56.1%, extracorporeal: 56.5%). Kidney function recovery rates were comparable (OR 1.26; 95% CI, 0.81\u20131.95;\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.30), though time to kidney function recovery was significantly shorter with PD (mean difference \u22123.34 days, 95% CI \u22123.95 to \u22122.73,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.00001). Infection rates were similar between modalities (OR 1.02, 95% CI 0.47\u20132.22,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.96).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This meta-analysis demonstrates comparable clinical outcomes between PD and extracorporeal dialysis for AKI management across key metrics including mortality, kidney function recovery, and infectious complications. PD was associated with faster time to kidney function recovery. These findings support the use of PD as an equally effective treatment for AKI-D. Further research is needed to evaluate patient-reported outcomes and patient modality preference.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/08968608261448781","type":"journal-article","created":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T14:42:26Z","timestamp":1778251346000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Peritoneal dialysis results in similar outcomes to extracorporeal dialysis in acute kidney injury: A systematic review and meta-analysis"],"prefix":"10.1177","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4259-361X","authenticated-orcid":false,"given":"Rajiv Hans","family":"Menghrajani","sequence":"first","affiliation":[{"name":"Lincoln Medical Center"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mirtha C","family":"Almanzar","sequence":"additional","affiliation":[{"name":"Lincoln Medical Center"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Angela","family":"Matabang","sequence":"additional","affiliation":[{"name":"Lincoln Medical Center"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saifudheen","family":"Faroog","sequence":"additional","affiliation":[{"name":"Lincoln Medical Center"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siena","family":"Placino","sequence":"additional","affiliation":[{"name":"St. Luke's Medical Center College of Medicine \u2013 William H. Quasha Memorial, Quezon City, Philippines"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anika","family":"Sinha","sequence":"additional","affiliation":[{"name":"Brown University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John Paul","family":"Aparece","sequence":"additional","affiliation":[{"name":"Texas Tech University Health Science Center"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0811-6900","authenticated-orcid":false,"given":"Ankur D","family":"Shah","sequence":"additional","affiliation":[{"name":"Warren Alpert Medical School of Brown University"},{"name":"Division of Kidney Disease and Hypertension, Department of Medicine, Rhode Island Hospital, Providence, Rhode Island"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2026,5,8]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/ckj\/sfaa177"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-021-06454-7"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-015-3934-7"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e3182281f1b"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrneph.2013.282"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1159\/000337487"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.01730221"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-79533-6"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2014.10.017"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1159\/000445846"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/ckj\/sfac201"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.3747\/pdi.2016.00178"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.3747\/pdi.2018.00029"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1177\/0896860820931662"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1177\/0896860819887286"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.3747\/pdi.2014.00041"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.3747\/pdi.2017.00190"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.3747\/pdi.2014.00185"},{"key":"e_1_3_2_20_2","article-title":"Framework for establishing integrated kidney care programs in low- and middle-income countries","volume":"10","author":"Tonelli M","year":"2020","unstructured":"Tonelli M, Nkunu V, Varghese C, et al. Framework for establishing integrated kidney care programs in low- and middle-income countries. Kidney Int Suppl (2011) 2020; 10: e19\u2013e23.","journal-title":"Kidney Int Suppl (2011)"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-194611000-00004"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1177\/0896860820970834"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41581-022-00623-7"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1159\/000046671"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfi296"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.34067\/KID.0005192020"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ekir.2020.07.017"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2020.06.001"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2021.04.017"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2020.06.012"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.01540213"},{"key":"e_1_3_2_32_2","article-title":"Peritoneal dialysis for acute kidney injury","volume":"12","author":"Liu L","year":"2017","unstructured":"Liu L, Zhang L, Liu GJ, et al. Peritoneal dialysis for acute kidney injury. Cochrane Database Syst Rev 2017; 12: CD011457.","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0138811"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2019.10.013"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0041-1741080"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1111\/sdi.12856"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2020.03.028"},{"key":"e_1_3_2_38_2","unstructured":"Medicare and Medicaid programs; CY 2025 end-stage renal disease prospective payment system and quality incentive program; and changes to the ESRD Treatment Choices Model (CMS-1805-F). 2024."},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa020074"},{"key":"e_1_3_2_40_2","article-title":"High volume peritoneal dialysis vs daily hemodialysis: a randomized, controlled trial in patients with acute kidney injury","volume":"108","author":"Gabriel DP","year":"2008","unstructured":"Gabriel DP, Caramori JT, Martim LC, et al. High volume peritoneal dialysis vs daily hemodialysis: a randomized, controlled trial in patients with acute kidney injury. Kidney Int Suppl 2008; 108: S87\u2013S93.","journal-title":"Kidney Int Suppl"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.3747\/pdi.2009.00231"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11255-012-0301-2"},{"key":"e_1_3_2_43_2","first-page":"2015","article-title":"Efficacy of acute peritoneal dialysis (PD) over sustained low efficiency dialysis (SLED) in critically ill ICU patients with acute kidney injury - A comparative study","volume":"26","author":"Bora M","year":"2015","unstructured":"Bora M. Efficacy of acute peritoneal dialysis (PD) over sustained low efficiency dialysis (SLED) in critically ill ICU patients with acute kidney injury - A comparative study. J Am Soc Nephrol 2015; 26: 2015.","journal-title":"J Am Soc Nephrol"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1111\/1744-9987.12660"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.0000000000000482"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2021.01.002"}],"container-title":["Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/08968608261448781","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/08968608261448781","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/08968608261448781","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T07:20:06Z","timestamp":1778484006000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/08968608261448781"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,8]]},"references-count":45,"alternative-id":["10.1177\/08968608261448781"],"URL":"https:\/\/doi.org\/10.1177\/08968608261448781","relation":{},"ISSN":["0896-8608","1718-4304"],"issn-type":[{"value":"0896-8608","type":"print"},{"value":"1718-4304","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,8]]},"article-number":"08968608261448781"}}