{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T16:39:06Z","timestamp":1790786346996,"version":"4.1.0"},"reference-count":42,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T00:00:00Z","timestamp":1782691200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Hunan province college students research learning and innovative experiment project","award":["No. S202510542396"],"award-info":[{"award-number":["No. S202510542396"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["No.82500884"],"award-info":[{"award-number":["No.82500884"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004735","name":"Natural Science Foundation of Hunan Province","doi-asserted-by":"publisher","award":["No. 2024JJ9280"],"award-info":[{"award-number":["No. 2024JJ9280"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Perit Dial Int"],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Peritoneal fibrosis (PF) limits the long-term use of peritoneal dialysis (PD), with effective therapies lacking. Ferroptosis, an iron-dependent cell death process, has been implicated in organ fibrosis, but its role in PD-related PF remains unexplored. Quercetin, a natural flavonoid, possesses potential anti-fibrotic and anti-ferroptotic properties.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>PD effluent cells from patients with different dialysis durations were analyzed for the expression of fibrosis markers (\u03b1-smooth muscle actin and collagen I) and ferroptosis-related markers (glutathione peroxidase 4 (GPX4) and solute carrier family 7 member 11 (SLC7A11)). In vitro, human peritoneal mesothelial cells (MeT-5A) exposed to high glucose were treated with quercetin to examine its effects on mitochondrial ultrastructure and marker expression. A rat model of PF was established through daily intraperitoneal injection of high-glucose dialysate, with or without quercetin administration, to evaluate histological and molecular changes in the parietal peritoneum.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Prolonged dialysis duration was associated with upregulated fibrotic markers and downregulated ferroptosis-related genes in patient samples. In vitro, high glucose induced mitochondrial damage and a profibrotic phenotype in MeT-5A cells, which were significantly attenuated by quercetin. Quercetin restored the expression of GPX4 and SLC7A11, comparable to the effects of the ferroptosis inhibitor ferrostatin-1. In vivo, quercetin treatment markedly alleviated high-glucose-induced peritoneal thickening and fibrosis while enhancing the expression of ferroptosis suppressors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our findings demonstrate that ferroptosis contributes to the pathogenesis of PD-associated PF. Quercetin mitigates fibrotic progression by modulating ferroptosis, highlighting its promise as a novel therapeutic agent for preventing or treating this complication.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/08968608261463605","type":"journal-article","created":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T13:59:36Z","timestamp":1782741576000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Quercetin attenuates peritoneal fibrosis by upregulating ferroptosis-related glutathione peroxidase 4 (GPX4) and solute carrier family 7 member 11 (SLC7A11) in MeT-5A and rat models: Supported by clinical mRNA expression data"],"prefix":"10.1177","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2319-5640","authenticated-orcid":false,"given":"Shaxi","family":"Ouyang","sequence":"first","affiliation":[{"name":"Department of Nephrology and Laboratory of Kidney Disease, Hunan Provincial People's Hospital (The First-Affiliated Hospital of Hunan Normal University), Hunan Clinical Research Center for Chronic Kidney Disease, Hunan Engineering Research Center for Kidney Disease Prevention and Rehabilitation, Changsha Innovation Center for Integrated Diagnosis and Treatment Technology of Metabolic Dysfunction-Associated Kidney Diseases"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Chen","sequence":"additional","affiliation":[{"name":"The Central Hospital of Yongzhou (Yongzhou Hospital Affiliated to University of South China)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siyuan","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine, Zhangjiajie Hospital Affiliated to Hunan Normal University, Zhangjiajie, Hunan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangyi","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Laboratory of Kidney Disease, Hunan Provincial People's Hospital (The First-Affiliated Hospital of Hunan Normal University), Hunan Clinical Research Center for Chronic Kidney Disease, Hunan Engineering Research Center for Kidney Disease Prevention and Rehabilitation, Changsha Innovation Center for Integrated Diagnosis and Treatment Technology of Metabolic Dysfunction-Associated Kidney Diseases"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunling","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Laboratory of Kidney Disease, Hunan Provincial People's Hospital (The First-Affiliated Hospital of Hunan Normal University), Hunan Clinical Research Center for Chronic Kidney Disease, Hunan Engineering Research Center for Kidney Disease Prevention and Rehabilitation, Changsha Innovation Center for Integrated Diagnosis and Treatment Technology of Metabolic Dysfunction-Associated Kidney 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