{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T01:53:24Z","timestamp":1777859604096,"version":"3.51.4"},"reference-count":55,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2010,3,31]],"date-time":"2010-03-31T00:00:00Z","timestamp":1269993600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Pharmacy Practice"],"published-print":{"date-parts":[[2010,6]]},"abstract":"<jats:p>\n                    Gilles de la Tourette syndrome (GTS) is a neuropsychiatric, lifelong disorder with onset in childhood. The essential features of this disorder are multiple motor tics and one or more vocalizations. The neurochemical pathophysiology of GTS involves an unknown abnormality in the central dopaminergic system. Atypical antipsychotics, such as aripiprazole, serve as a new therapeutic option for GTS. The authors describe a unique case of Tourette\u2019s syndrome (TS) in an adolescent in which aripiprazole resolved the patient\u2019s symptoms. A 17-year-old, 5\u203211\u2032\u2032 tall, African American male weighing 220 lbs was diagnosed with TS at 9 years old. By age 16, the patient developed prominent symptoms of intermitted eye blinking, forehead raising, finger snapping, heavy breathing, and head bobbing. Clonidine, in addition to homeopathic remedies (\n                    <jats:italic toggle=\"yes\">N<\/jats:italic>\n                    -acetylcholine and alpha lipoic acid), was administered to the patient without significant diminution of symptoms. Later, aripiprazole was initiated at 5 mg\/d. As a result, noticeable symptomatic improvement occurred within 48 hours. Aripiprazole was titrated over the next 4 weeks to 6.5 mg\/d, with significant results. Over the next 6 months, aripiprazole was titrated again to 10 mg\/d with additional symptom reduction. This case illustrates a patient who responded to aripiprazole with no reported adverse effects, when standard therapy failed to improve symptoms.\n                  <\/jats:p>","DOI":"10.1177\/0897190009358771","type":"journal-article","created":{"date-parts":[[2010,3,31]],"date-time":"2010-03-31T20:59:37Z","timestamp":1270069177000},"page":"239-244","source":"Crossref","is-referenced-by-count":5,"title":["Aripiprazole for the Treatment of Adolescent Tourette\u2019s Syndrome"],"prefix":"10.1177","volume":"23","author":[{"given":"Kendra","family":"Lewis","sequence":"first","affiliation":[{"name":"Florida A&amp;M University College of Pharmacy and Pharmaceutical Sciences, Jackson Medical Towers, Miami, FL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leonard","family":"Rappa","sequence":"additional","affiliation":[{"name":"Florida A&amp;M University College of Pharmacy and Pharmaceutical Sciences, Jackson Medical Towers, Miami, FL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Devon A.","family":"Sherwood-Jachimowicz","sequence":"additional","affiliation":[{"name":"Palm Beach Atlantic University, Lloyd L. Gregory School of Pharmacy, West Palm Beach, FL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margareth","family":"Larose-Pierre","sequence":"additional","affiliation":[{"name":"Florida A&amp;M University College of Pharmacy and Pharmaceutical Sciences, Jackson Medical Towers, Miami, FL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2010,3,31]]},"reference":[{"key":"e_1_2_2_2_2","volume-title":"Diagnostic and Statistical Manual of Mental Disorders","author":"American Psychiatric Association","year":"2000","unstructured":"American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders, 4th ed. Text revised (DSM-IV-TR). Washington, DC: Author; 2000.","edition":"4"},{"key":"e_1_2_2_3_2","article-title":"Tourette syndrome","author":"Jankovic J","year":"2008","unstructured":"Jankovic J. Tourette syndrome. UpToDate. 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