{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T01:54:14Z","timestamp":1777859654410,"version":"3.51.4"},"reference-count":25,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2012,4,27]],"date-time":"2012-04-27T00:00:00Z","timestamp":1335484800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pharmacy Practice"],"published-print":{"date-parts":[[2012,8]]},"abstract":"<jats:p>Background: Tablet splitting is a common practice for multiple reasons including cost savings; however, it does not necessarily result in weight-uniform half-tablets. Objectives: To determine weight uniformity of half-tablets resulting from splitting 4 products available in the Jordanian market and investigate the effect of tablet characteristics on weight uniformity of half-tablets. Methods: Ten random tablets each of warfarin 5\u00a0mg, digoxin 0.25 mg, phenobarbital 30 mg, and prednisolone 5 mg were weighed and split by 6 PharmD students using a knife. The resulting half-tablets were weighed and evaluated for weight uniformity. Other relevant physical characteristics of the 4 products were measured. Results: The average tablet hardness of the sampled tablets ranged from 40.3 N to 68.9 N. Digoxin, phenobarbital, and prednisolone half-tablets failed the weight uniformity test; however, warfarin half-tablets passed. Digoxin, warfarin, and phenobarbital tablets had a score line and warfarin tablets had the deepest score line of 0.81 mm. Conclusion: Splitting warfarin tablets produces weight-uniform half-tablets that may possibly be attributed to the hardness and the presence of a deep score line. Digoxin, phenobarbital, and prednisolone tablet splitting produces highly weight variable half-tablets. This can be of clinical significance in the case of the narrow therapeutic index medication digoxin.<\/jats:p>","DOI":"10.1177\/0897190012442716","type":"journal-article","created":{"date-parts":[[2012,4,28]],"date-time":"2012-04-28T20:15:59Z","timestamp":1335644159000},"page":"471-476","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":40,"title":["Tablet Splitting and Weight Uniformity of Half-Tablets of 4 Medications in Pharmacy Practice"],"prefix":"10.1177","volume":"25","author":[{"given":"Linda M.","family":"Tahaineh","sequence":"first","affiliation":[{"name":"Department of Clinical Pharmacy, Jordan University of Science & Technology (JUST), Irbid, Jordan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shadi F.","family":"Gharaibeh","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Technology, Jordan University of Science & Technology (JUST), Irbid, Jordan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2012,4,27]]},"reference":[{"key":"bibr1-0897190012442716","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-006-0202-3"},{"key":"bibr2-0897190012442716","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejps.2003.10.018"},{"issue":"6","key":"bibr3-0897190012442716","first-page":"453","volume":"8","author":"Gee M","year":"2002","journal-title":"J Manag Care Pharm"},{"key":"bibr4-0897190012442716","unstructured":"Institute for safe medication practices. Tablet splitting: do it only if you \u201chalf\u201d to, and then do it safely. http:\/\/ismp.org\/Newsletters\/acutecare\/articles\/20060518.asp. Accessed May 16, 2010."},{"key":"bibr5-0897190012442716","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2005.02.019"},{"issue":"4","key":"bibr6-0897190012442716","first-page":"22","volume":"7","author":"Rindone JP","year":"2000","journal-title":"JCOM"},{"key":"bibr7-0897190012442716","doi-asserted-by":"publisher","DOI":"10.1176\/ps.2007.58.2.201"},{"issue":"3","key":"bibr8-0897190012442716","first-page":"253","volume":"15","author":"Hill SW","year":"2009","journal-title":"J Manag Care Pharm"},{"issue":"5","key":"bibr9-0897190012442716","first-page":"401","volume":"9","author":"Polli JE","year":"2003","journal-title":"J Manag Care Pharm"},{"key":"bibr10-0897190012442716","doi-asserted-by":"publisher","DOI":"10.2165\/00019053-200220050-00005"},{"issue":"7","key":"bibr11-0897190012442716","first-page":"105","volume":"140","author":"Arnet I","year":"2010","journal-title":"Swiss Med Wkly"},{"key":"bibr12-0897190012442716","doi-asserted-by":"publisher","DOI":"10.1503\/cmaj.050176"},{"issue":"8","key":"bibr13-0897190012442716","first-page":"707","volume":"55","author":"Noviasky J","year":"2006","journal-title":"J Fam Pract"},{"issue":"3","key":"bibr14-0897190012442716","first-page":"272","volume":"15","author":"Navarro RP","year":"2009","journal-title":"J Manag Care Pharm"},{"key":"bibr15-0897190012442716","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2648.2010.05477.x"},{"key":"bibr16-0897190012442716","unstructured":"United states pharmacopeia 26-National Formulary 21\n                      . Rockville, MD: The United States Pharmacopeial Convention, Inc. 2002:2227\u20132229."},{"key":"bibr17-0897190012442716","doi-asserted-by":"publisher","DOI":"10.1331\/108658002763508489"},{"key":"bibr18-0897190012442716","first-page":"69","volume":"35","author":"Grissinger M","year":"2010","journal-title":"P T"},{"key":"bibr19-0897190012442716","doi-asserted-by":"publisher","DOI":"10.1097\/01.NME.0000403197.60545.39"},{"key":"bibr20-0897190012442716","doi-asserted-by":"publisher","DOI":"10.1208\/s12249-009-9365-4"},{"key":"bibr21-0897190012442716","doi-asserted-by":"publisher","DOI":"10.1378\/chest.08-0670"},{"key":"bibr22-0897190012442716","doi-asserted-by":"publisher","DOI":"10.1097\/MAJ.0b013e318176b94d"},{"key":"bibr23-0897190012442716","unstructured":"Jordan food and drug administration. http:\/\/www.jfda.jo\/barcode_java\/index.jsp?LangID=en. Accessed May 17, 2010."},{"key":"bibr24-0897190012442716","unstructured":"U.S. Food and Drug Administration. Guidance for Industry Tablet Scoring: Nomenclature, Labeling, and Data for Evaluation. Draft Guidance (August 2011). Available at: http:\/\/www.fda.gov\/downloads\/Drugs\/GuidanceComplianceRegulatoryInformation\/Guidances\/UCM269921.pdf. Accessed January 7, 2011."},{"key":"bibr25-0897190012442716","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6947-9-30"}],"container-title":["Journal of Pharmacy Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0897190012442716","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0897190012442716","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0897190012442716","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T00:35:09Z","timestamp":1777509309000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0897190012442716"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,4,27]]},"references-count":25,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2012,8]]}},"alternative-id":["10.1177\/0897190012442716"],"URL":"https:\/\/doi.org\/10.1177\/0897190012442716","relation":{},"ISSN":["0897-1900","1531-1937"],"issn-type":[{"value":"0897-1900","type":"print"},{"value":"1531-1937","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,4,27]]}}}