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Anticoagulant prophylaxis with warfarin is effective in preventing stroke in eligible patients with AF, but in real-world practice this agent, though inexpensive, is underutilized. Moreover, warfarin has notable drawbacks that result in suboptimal anticoagulation and, as a result, greater disease burden and higher costs. Newer oral antithrombotic drugs with a wide therapeutic window and no requirement for routine coagulation monitoring may be as efficacious as warfarin and, given the costs associated with managing warfarin therapy, they may also prove to be more cost effective.<\/jats:p>","DOI":"10.1177\/0897190012452309","type":"journal-article","created":{"date-parts":[[2012,7,27]],"date-time":"2012-07-27T09:31:41Z","timestamp":1343381501000},"page":"204-213","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Current Approaches to Anticoagulation for Reducing Risk of Atrial Fibrillation\u2013Related Stroke"],"prefix":"10.1177","volume":"26","author":[{"given":"Cynthia A.","family":"Sanoski","sequence":"first","affiliation":[{"name":"Department of Pharmacy Practice, Jefferson School of Pharmacy, Thomas Jefferson University, Philadelphia, Pennsylvania, PA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2012,7,25]]},"reference":[{"key":"bibr1-0897190012452309","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0b013e3182009701"},{"key":"bibr2-0897190012452309","unstructured":"World Health Organization. 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