{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T01:54:50Z","timestamp":1777859690485,"version":"3.51.4"},"reference-count":18,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2014,2,13]],"date-time":"2014-02-13T00:00:00Z","timestamp":1392249600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pharmacy Practice"],"published-print":{"date-parts":[[2015,2]]},"abstract":"<jats:p>\n                    Purpose: Alogliptin is the newest dipeptidyl peptidase 4 (DPP-4) inhibitor approved for the treatment of type 2 diabetes either alone or in combination with other antidiabetic agents. The purpose of this review is to highlight the clinical studies that led to Food and Drug Administration approval of alogliptin and to provide insight into the place in therapy for the management of type 2 diabetes mellitus. Summary: As a DPP-4 inhibitor, alogliptin raises postprandial levels of glucagon-like peptide 1, leading to insulin secretion and glucose homeostasis. When given as monotherapy, alogliptin has the ability to reduce glycoslate hemoglobin A\n                    <jats:sub>1c<\/jats:sub>\n                    (HbA\n                    <jats:sub>1c<\/jats:sub>\n                    ) by 0.4% to 1.0%. Combination therapy yielded similar reductions with some variability depending on the agent with which alogliptin was combined. The mean HbA\n                    <jats:sub>1c<\/jats:sub>\n                    reduction seen with alogliptin is relative to the degree of HbA\n                    <jats:sub>1c<\/jats:sub>\n                    elevation at baseline. Alogliptin appears to be weight neutral and is relatively well tolerated with few adverse effects. Furthermore, alogliptin has proven to result in comparable efficacy and tolerability in the elderly as in the younger population. Conclusion: Alogliptin alone or in combination with other antidiabetic agents has shown a significant reduction in HbA\n                    <jats:sub>1c<\/jats:sub>\n                    while remaining safe and tolerable. The efficacy profile of alogliptin is comparable to other DPP-4 inhibitors. Additional long-term research is necessary with regard to long-standing efficacy and effects on beta-cell function.\n                  <\/jats:p>","DOI":"10.1177\/0897190014522063","type":"journal-article","created":{"date-parts":[[2014,2,14]],"date-time":"2014-02-14T22:14:58Z","timestamp":1392416098000},"page":"99-106","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":20,"title":["Alogliptin"],"prefix":"10.1177","volume":"28","author":[{"given":"Adriane B.","family":"Marino","sequence":"first","affiliation":[{"name":"Wingate University School of Pharmacy, Wingate, NC, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sabrina W.","family":"Cole","sequence":"additional","affiliation":[{"name":"Wingate University School of Pharmacy, Wingate, NC, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2014,2,13]]},"reference":[{"key":"bibr1-0897190014522063","unstructured":"American Diabetes Association. National Diabetes Fact Sheet; 2011. http:\/\/www.diabetes.org\/diabetes-basics\/diabetes-statistics\/. Accessed May 20, 2013."},{"key":"bibr2-0897190014522063","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1994.00420210113013"},{"key":"bibr3-0897190014522063","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0802987"},{"key":"bibr4-0897190014522063","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)60697-8"},{"key":"bibr5-0897190014522063","doi-asserted-by":"publisher","DOI":"10.1016\/j.annepidem.2007.10.007"},{"key":"bibr6-0897190014522063","unstructured":"Nesina [package insert]. 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