{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T02:18:35Z","timestamp":1784945915971,"version":"3.55.0"},"reference-count":10,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2014,8,3]],"date-time":"2014-08-03T00:00:00Z","timestamp":1407024000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pharmacy Practice"],"published-print":{"date-parts":[[2016,4]]},"abstract":"\n Background:<\/jats:title>\n The cephalosporin class has been associated with an increased risk of bleeding among elderly patients receiving warfarin. Urinary tract infections (UTI) are the most prevalent infection in elderly patients.<\/jats:p>\n <\/jats:sec>\n \n Objective:<\/jats:title>\n To determine the extent of interaction between antibiotics used in the treatment of UTI, particularly specific cephalosporins and warfarin.<\/jats:p>\n <\/jats:sec>\n \n Methods:<\/jats:title>\n A retrospective chart review was conducted on chronic warfarin patients with a diagnosis of UTI treated with ceftriaxone, a first-generation cephalosporin, penicillin, or ciprofloxacin. The primary outcome was the comparison of the extent of international normalized ratio (INR) change from baseline between each antibiotic group.<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n The ceftriaxone group was found to have a statistically significant higher peak INR value compared to all other studied antibiotics (ceftriaxone: 3.56, first-generation cephalosporins: 2.66, penicillins: 2.98, ciprofloxacin: 2.3; P = .004), a statistically significant greater extent of change in INR value (+1.19, +0.66, +0.8, +0.275; P = .006), and a statistically significant greater percentage change in INR value when compared to ciprofloxacin (54.4% vs 12.7%; P = .037).<\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n Ceftriaxone interacts with warfarin to increase a patient\u2019s INR value more than other commonly administered antibiotics for UTI treatment. Other antibiotics should be preferred for UTI treatment in patients on warfarin.<\/jats:p>\n <\/jats:sec>","DOI":"10.1177\/0897190014544798","type":"journal-article","created":{"date-parts":[[2014,8,4]],"date-time":"2014-08-04T21:59:00Z","timestamp":1407189540000},"page":"121-124","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":16,"title":["Ceftriaxone Potentiates Warfarin Activity Greater Than Other Antibiotics in the Treatment of Urinary Tract Infections"],"prefix":"10.1177","volume":"29","author":[{"given":"Lindsay M.","family":"Saum","sequence":"first","affiliation":[{"name":"Department of Pharmacy Practice, Butler University College of Pharmacy and Health Sciences, Indianapolis, IN, USA"},{"name":"Department of Pharmacy, St Vincent Hospital, Indianapolis, IN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan P.","family":"Balmat","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Cleveland Clinic, Cleveland, OH, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2014,8,3]]},"reference":[{"key":"bibr1-0897190014544798","doi-asserted-by":"publisher","DOI":"10.1378\/chest.1412S3"},{"key":"bibr2-0897190014544798","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.165.10.1095"},{"key":"bibr3-0897190014544798","doi-asserted-by":"publisher","DOI":"10.1503\/cmaj.070946"},{"key":"bibr4-0897190014544798","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2011.08.014"},{"key":"bibr5-0897190014544798","doi-asserted-by":"publisher","DOI":"10.2146\/ajhp100681"},{"key":"bibr6-0897190014544798","doi-asserted-by":"publisher","DOI":"10.1001\/archinternmed.2010.37"},{"key":"bibr7-0897190014544798","volume-title":"Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc","author":"Institute of Medicine, Food and Nutrition Board","year":"2001"},{"issue":"3","key":"bibr8-0897190014544798","first-page":"311","volume":"87","author":"Conly JM","year":"1992","journal-title":"Am J Gastroenterol"},{"key":"bibr9-0897190014544798","volume-title":"Rocephin (ceftriaxone) [package insert]","year":"2004"},{"key":"bibr10-0897190014544798","doi-asserted-by":"publisher","DOI":"10.1345\/aph.1K605"}],"container-title":["Journal of Pharmacy Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0897190014544798","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0897190014544798","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0897190014544798","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T00:36:05Z","timestamp":1777509365000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0897190014544798"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,8,3]]},"references-count":10,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2016,4]]}},"alternative-id":["10.1177\/0897190014544798"],"URL":"https:\/\/doi.org\/10.1177\/0897190014544798","relation":{},"ISSN":["0897-1900","1531-1937"],"issn-type":[{"value":"0897-1900","type":"print"},{"value":"1531-1937","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,8,3]]}}}