{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T01:55:04Z","timestamp":1777859704301,"version":"3.51.4"},"reference-count":14,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2014,8,11]],"date-time":"2014-08-11T00:00:00Z","timestamp":1407715200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pharmacy Practice"],"published-print":{"date-parts":[[2015,12]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Several nomograms include recommendations to give intravenous (IV) vancomycin at 8-hour dosing intervals (Q8H). However, there is a lack of detailed data regarding this dosing recommendation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>A retrospective chart review of 100 patients who received 107 treatment courses of vancomycin Q8H for at least 5 days was performed. Distribution of vancomycin trough levels and rate of nephrotoxicity were evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Median patient age was 38 years (interquartile range [IQR] 27-50 years), median weight was 67 kg (IQR 55-79 kg), and median creatinine clearance was 124 mL\/min (IQR 101-147 mL\/min). Median duration of Q8H dosing was 9 days (IQR 7-12 days). Within the initial 96 hours, only 7% (7 of 104) of maximum trough concentrations were &gt;20 mg\/L (median dose 15 mg\/kg [IQR 15-18 mg\/kg]). After 96 hours of Q8H dosing, 34% (30 of 89) of maximum troughs were &gt;20 mg\/L (median dose 17 mg\/kg [IQR 15-20 mg\/kg]), P = .0005. The rate of nephrotoxicity was 4%.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>We observed an increase in the percentage of trough levels &gt;20 mg\/L later during treatment courses of vancomycin IV Q8H with a relatively small corresponding increase in vancomycin dose. Close monitoring of trough levels (eg, every 3 days) with prolonged courses of vancomycin IV Q8H is warranted.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0897190014544817","type":"journal-article","created":{"date-parts":[[2014,8,11]],"date-time":"2014-08-11T23:44:53Z","timestamp":1407800693000},"page":"511-517","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Evaluation of Treatment Courses When Vancomycin Is Given Every 8 Hours in Adult Patients"],"prefix":"10.1177","volume":"28","author":[{"given":"Erica","family":"Brumer","sequence":"first","affiliation":[{"name":"Department of Pharmacy, NYU Langone Medical Center, New York, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanina","family":"Dubrovskaya","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, NYU Langone Medical Center, New York, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco R.","family":"Scipione","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, NYU Langone Medical Center, New York, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caitlin","family":"Aberle","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, NYU Langone Medical Center, New York, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph","family":"Rahimian","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine, NYU Langone Medical Center, New York, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Papadopoulos","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, NYU Langone Medical Center, New York, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2014,8,11]]},"reference":[{"key":"bibr1-0897190014544817","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciq146"},{"key":"bibr2-0897190014544817","doi-asserted-by":"publisher","DOI":"10.2146\/ajhp080434"},{"key":"bibr3-0897190014544817","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cit178"},{"key":"bibr4-0897190014544817","doi-asserted-by":"publisher","DOI":"10.1086\/600877"},{"key":"bibr5-0897190014544817","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01602-07"},{"key":"bibr6-0897190014544817","doi-asserted-by":"publisher","DOI":"10.1016\/S0272-6386(88)80168-9"},{"key":"bibr7-0897190014544817","doi-asserted-by":"publisher","DOI":"10.1002\/j.1875-9114.1985.tb03441.x"},{"key":"bibr8-0897190014544817","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.32.6.848"},{"key":"bibr9-0897190014544817","doi-asserted-by":"publisher","DOI":"10.1592\/phco.19.4.257.30933"},{"key":"bibr10-0897190014544817","doi-asserted-by":"publisher","DOI":"10.1592\/phco.31.5.441"},{"key":"bibr11-0897190014544817","volume-title":"Characterization of Vancomycin Pharmacokinetic Parameters in Young and Elderly Patients With Normal Renal Function Using a Bayesian Forecasting Technique","author":"Vance-Bryan K","year":"1999"},{"issue":"1","key":"bibr12-0897190014544817","doi-asserted-by":"crossref","first-page":"13","DOI":"10.4212\/cjhp.v63i1.863","volume":"63","author":"Legal M","year":"2010","journal-title":"Can J Hosp Pharm"},{"key":"bibr13-0897190014544817","doi-asserted-by":"publisher","DOI":"10.1097\/00007691-199604000-00007"},{"key":"bibr14-0897190014544817","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01568-12"}],"container-title":["Journal of Pharmacy Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0897190014544817","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0897190014544817","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0897190014544817","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T00:35:59Z","timestamp":1777509359000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0897190014544817"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,8,11]]},"references-count":14,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2015,12]]}},"alternative-id":["10.1177\/0897190014544817"],"URL":"https:\/\/doi.org\/10.1177\/0897190014544817","relation":{},"ISSN":["0897-1900","1531-1937"],"issn-type":[{"value":"0897-1900","type":"print"},{"value":"1531-1937","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,8,11]]}}}