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Aminoglycosides are concentration-dependent, bactericidal agents that undergo active transport into the cell where they inhibit protein synthesis on the 30S subunit of the bacterial ribosome. As the use of aminoglycosides became more widespread, the toxic effects of these agents, most notably ototoxicity and nephrotoxicity, became more apparent. When other, safer, antimicrobial agents became available, the use of aminoglycosides sharply declined. The development of multi-drug resistance among bacteria has now lead clinicians to reexamine the role of the aminoglycosides in the treatment of serious infections. This review will revisit the mechanism and risk factors for the development of aminoglycoside-induced nephrotoxicity, as well as strategies to prevent patients from developing nephrotoxicity.<\/jats:p>","DOI":"10.1177\/0897190014546836","type":"journal-article","created":{"date-parts":[[2014,9,9]],"date-time":"2014-09-09T00:39:49Z","timestamp":1410223189000},"page":"573-577","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":223,"title":["Aminoglycoside-Induced Nephrotoxicity"],"prefix":"10.1177","volume":"27","author":[{"given":"Kurt A.","family":"Wargo","sequence":"first","affiliation":[{"name":"Division of Internal Medicine, Auburn University Harrison School of Pharmacy, Huntsville, AL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan D.","family":"Edwards","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Huntsville Hospital, Huntsville, AL, 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