{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:08:38Z","timestamp":1787018918378,"version":"build-2736575974"},"reference-count":10,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2016,7,8]],"date-time":"2016-07-08T00:00:00Z","timestamp":1467936000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pharmacy Practice"],"published-print":{"date-parts":[[2016,10]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>The emergence of resistant Escherichia coli to fluoroquinolones (FQs) is of growing concern, yet the latest guidelines for the treatment of pyelonephritis still recommend FQs as first-line treatment. Our primary objective was to determine the impact of discordant prescribing of FQs in E coli pyelonephritis on hospital length of stay (LOS) and early clinical response (ECR).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We retrospectively compared discordant and concordant prescribing of FQs for LOS and ECR. We also compared FQs, ceftriaxone, piperacillin\/tazobactam, and carbapenems for these clinical outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Forty-nine patients included in the comparison between discordant (n = 9) and concordant (n = 40) prescribing of FQs. There was significantly lower ECR in patients with discordant prescribing of FQs (38 of 40, 95% vs 5 of 9, 55.6%, P = .0074) and a trend toward longer LOS (4 [2.3] days vs 3 [2.0] days, P = .0571). Illness severity, estimated using Simplified Acute Physiology Score (SAPS II) score, was similar between groups ( P = .717).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>There was a significantly decreased ECR and a trend toward increased LOS when FQs were used in FQ-resistant E coli. Regarding alternative treatment for E coli pyelonephritis, ceftriaxone was as effective as concordant FQs and significantly better than discordant FQs.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0897190014568380","type":"journal-article","created":{"date-parts":[[2015,2,8]],"date-time":"2015-02-08T21:53:02Z","timestamp":1423432382000},"page":"467-471","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Clinical Impact of Discordant Prescribing of Fluoroquinolones and Alternative Treatments in\n                    <i>Escherichia coli<\/i>\n                    Pyelonephritis"],"prefix":"10.1177","volume":"29","author":[{"given":"Minh T.","family":"Hong","sequence":"first","affiliation":[{"name":"Texas Tech University Health Sciences Center School of Pharmacy, Lubbock, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles F.","family":"Seifert","sequence":"additional","affiliation":[{"name":"Texas Tech University Health Sciences Center School of Pharmacy, Lubbock, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2016,7,8]]},"reference":[{"issue":"5","key":"bibr1-0897190014568380","first-page":"519","volume":"84","author":"Colgan R","year":"2011","journal-title":"Am Fam Physician"},{"key":"bibr2-0897190014568380","volume-title":"UpToDate","author":"Hooton TM","year":"2012"},{"key":"bibr3-0897190014568380","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciq257"},{"key":"bibr4-0897190014568380","unstructured":"The Center for Disease Dynamics Economics & Policy at http:\/\/www.cddep.org\/projects\/resistance_map\/fluoroquinolone_resistant_escherichia_coli. Accessed by C.F. Seifert on December 11, 2014."},{"key":"bibr5-0897190014568380","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.35.9.1849"},{"key":"bibr6-0897190014568380","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2010.10.009"},{"key":"bibr7-0897190014568380","doi-asserted-by":"publisher","DOI":"10.1089\/mdr.2011.0139"},{"key":"bibr8-0897190014568380","doi-asserted-by":"publisher","DOI":"10.1001\/jama.283.12.1583"},{"issue":"2","key":"bibr9-0897190014568380","first-page":"ii67","volume":"53","author":"Wells WG","year":"2004","journal-title":"J Infect Chemother"},{"key":"bibr10-0897190014568380","doi-asserted-by":"publisher","DOI":"10.1007\/s10156-009-0721-9"}],"container-title":["Journal of Pharmacy Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0897190014568380","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0897190014568380","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0897190014568380","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T00:36:16Z","timestamp":1777509376000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0897190014568380"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,7,8]]},"references-count":10,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2016,10]]}},"alternative-id":["10.1177\/0897190014568380"],"URL":"https:\/\/doi.org\/10.1177\/0897190014568380","relation":{},"ISSN":["0897-1900","1531-1937"],"issn-type":[{"value":"0897-1900","type":"print"},{"value":"1531-1937","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,7,8]]}}}