{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T09:13:05Z","timestamp":1784193185813,"version":"3.55.0"},"reference-count":26,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2015,6,1]],"date-time":"2015-06-01T00:00:00Z","timestamp":1433116800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pharmacy Practice"],"published-print":{"date-parts":[[2015,8]]},"abstract":"<jats:p>A 13-year-old female experienced a recurrence of baclofen pump-related central nervous system (CNS) infection caused by Achromobacter, despite absence of retained foreign material. Due to the failure of meropenem (120 mg\/kg\/d in divided doses every 8 hours and infused over 30 minutes) in the initial infection, the dose was infused over 4 hours during the recurrence. Meropenem is an antibiotic for which efficacy is time dependent, and 4-hour versus 30-minute infusions have been shown to prolong the time the concentration of the antibiotic exceeds the minimum inhibitory concentration (MIC) of the organism at the site of infection (T&gt;MIC). Meropenem serum concentrations were obtained and indicated that T&gt;MIC was at least 75% of the dosing interval. Our patient improved with no noted recurrences or adverse effects on the extended-infusion meropenem regimen. Utilization of extended-infusion beta-lactam dosing whenever possible in the treatment of serious infections caused by gram-negative organisms should be considered, as this dosing appears to be safe and improves the probability of achieving pharmacokinetic\/pharmacodynamic goals.<\/jats:p>","DOI":"10.1177\/0897190015585757","type":"journal-article","created":{"date-parts":[[2015,6,1]],"date-time":"2015-06-01T21:30:24Z","timestamp":1433194224000},"page":"430-433","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["Success With Extended-Infusion Meropenem After Recurrence of Baclofen Pump-Related\n                    <i>Achromobacter Xylosoxidans<\/i>\n                    Meningitis in an Adolescent"],"prefix":"10.1177","volume":"28","author":[{"given":"Kristen R.","family":"Nichols","sequence":"first","affiliation":[{"name":"Department of Pharmacy Practice, Butler University College of Pharmacy and Health Sciences, Indianapolis, IN, USA"},{"name":"Department of Pharmacy, Riley Hospital for Children at Indiana University Health, Indianapolis, IN, USA"},{"name":"Department of Pediatrics, Ryan White Center for Pediatric Infectious Disease, Indiana University School of Medicine, Indianapolis, IN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chad A.","family":"Knoderer","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Practice, Butler University College of Pharmacy and Health Sciences, Indianapolis, IN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas G.","family":"Jackson","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Practice, Butler University College of Pharmacy and Health Sciences, Indianapolis, IN, USA"},{"name":"Nicholas G. Jackson was a PharmD Candidate at Butler University at the time of writing this manuscript, he has since graduated"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John J.","family":"Manaloor","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Ryan White Center for Pediatric Infectious Disease, Indiana University School of Medicine, Indianapolis, IN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John C.","family":"Christenson","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Ryan White Center for Pediatric Infectious Disease, Indiana University School of Medicine, Indianapolis, IN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2015,6,1]]},"reference":[{"key":"bibr1-0897190015585757","doi-asserted-by":"publisher","DOI":"10.1016\/j.pediatrneurol.2005.05.001"},{"key":"bibr2-0897190015585757","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0b013e318287f02a"},{"key":"bibr3-0897190015585757","doi-asserted-by":"publisher","DOI":"10.3171\/2009.6.PEDS0921"},{"key":"bibr4-0897190015585757","doi-asserted-by":"publisher","DOI":"10.3171\/2013.11.PEDS13253"},{"key":"bibr5-0897190015585757","doi-asserted-by":"publisher","DOI":"10.1017\/S0012162206000971"},{"issue":"1","key":"bibr6-0897190015585757","first-page":"9","volume":"104","author":"Vender JR","year":"2006","journal-title":"J Neurosurg"},{"key":"bibr7-0897190015585757","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/23.3.569"},{"key":"bibr8-0897190015585757","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/hct170"},{"key":"bibr9-0897190015585757","doi-asserted-by":"publisher","DOI":"10.1007\/BF01713580"},{"key":"bibr10-0897190015585757","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkt424"},{"key":"bibr11-0897190015585757","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-009-0837-y"},{"key":"bibr12-0897190015585757","doi-asserted-by":"publisher","DOI":"10.1086\/382690"},{"key":"bibr13-0897190015585757","doi-asserted-by":"publisher","DOI":"10.1345\/aph.1K060"},{"key":"bibr14-0897190015585757","doi-asserted-by":"publisher","DOI":"10.1592\/phco.24.8.803.36070"},{"key":"bibr15-0897190015585757","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/24.Supplement_2.S181"},{"key":"bibr16-0897190015585757","doi-asserted-by":"publisher","DOI":"10.1201\/b14095"},{"key":"bibr17-0897190015585757","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.39.8.1721"},{"key":"bibr18-0897190015585757","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.42.8.2012"},{"key":"bibr19-0897190015585757","doi-asserted-by":"publisher","DOI":"10.1592\/phco.26.9.1320"},{"key":"bibr20-0897190015585757","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.22051"},{"key":"bibr21-0897190015585757","doi-asserted-by":"publisher","DOI":"10.1016\/S0149-2918(04)80001-8"},{"key":"bibr22-0897190015585757","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinthera.2012.05.005"},{"key":"bibr23-0897190015585757","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02365-12"},{"key":"bibr24-0897190015585757","doi-asserted-by":"publisher","DOI":"10.1086\/510590"},{"key":"bibr25-0897190015585757","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2010.08.016"},{"key":"bibr26-0897190015585757","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2009.07.004"}],"container-title":["Journal of Pharmacy Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0897190015585757","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0897190015585757","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0897190015585757","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T00:36:13Z","timestamp":1777509373000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0897190015585757"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,6,1]]},"references-count":26,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2015,8]]}},"alternative-id":["10.1177\/0897190015585757"],"URL":"https:\/\/doi.org\/10.1177\/0897190015585757","relation":{},"ISSN":["0897-1900","1531-1937"],"issn-type":[{"value":"0897-1900","type":"print"},{"value":"1531-1937","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,6,1]]}}}