{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T00:31:26Z","timestamp":1778545886625,"version":"3.51.4"},"reference-count":13,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2016,7,8]],"date-time":"2016-07-08T00:00:00Z","timestamp":1467936000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pharmacy Practice"],"published-print":{"date-parts":[[2017,4]]},"abstract":"<jats:p>We describe the first successful case of posaconazole salvage therapy for mucormycosis with concomitant sirolimus (SRL) maintenance immunosuppression following liver transplantation, despite black box drug interaction following intolerance to first-line tacrolimus and amphotericin due to nephrotoxicity and neurotoxicity. This case describes a 55-year-old female who developed rhinocerebral mucormycosis 108 days after liver transplantation. After 3 months of posaconazole therapy, the patient remains free of disease at 3 years posttransplant. This case report illustrates successful resolution of mucormycosis without SRL toxicity to resolve nephrotoxicity of long-term amphotericin on top of already nephrotoxic immunosuppression. With higher bioavailability of recently FDA-approved posaconazole delayed release tablets, this azole may be a therapeutic option for transplant patients who need to remain on CYP3A4-metabolized immunosuppressive agents.<\/jats:p>","DOI":"10.1177\/0897190016628702","type":"journal-article","created":{"date-parts":[[2016,2,10]],"date-time":"2016-02-10T20:33:15Z","timestamp":1455136395000},"page":"261-265","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":12,"title":["Salvage Treatment of Mucormycosis Post-Liver Transplant With Posaconazole During Sirolimus Maintenance Immunosuppression"],"prefix":"10.1177","volume":"30","author":[{"given":"Jennifer C.","family":"Deyo","sequence":"first","affiliation":[{"name":"Department of Pharmacy, University of North Carolina, Memorial Hospital, Chapel Hill, NC, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicole","family":"Nicolsen","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Vidant Medical Center, Greenville, NC, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne","family":"Lachiewicz","sequence":"additional","affiliation":[{"name":"Department of Medicine, School of Medicine, University of North Carolina, Chapel Hill, NC, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomasz","family":"Kozlowski","sequence":"additional","affiliation":[{"name":"Department of Surgery, School of Medicine, University of North Carolina, Chapel Hill, NC, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2016,7,8]]},"reference":[{"key":"bibr1-0897190016628702","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.12118"},{"key":"bibr2-0897190016628702","unstructured":"Noxafil [package insert]. 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