{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T22:48:51Z","timestamp":1782859731643,"version":"3.54.5"},"reference-count":31,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2016,7,8]],"date-time":"2016-07-08T00:00:00Z","timestamp":1467936000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pharmacy Practice"],"published-print":{"date-parts":[[2017,4]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>The purpose of this article is to review the safety, efficacy, and role of efinaconazole and tavaborole in the treatment of onychomycosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Summary:<\/jats:title>\n                    <jats:p>Onychomycosis is a fungal infection of the nail caused by dermatophytes, yeasts, and nondermatophyte fungi. Distal and lateral subungual onychomycosis (DLSO) accounts for the majority of the cases. These infections cause structural damage to the nail which makes treatment difficult. Both oral and topical agents exist for the treatment of onychomycosis. Oral medications have generally been more effective, yet adverse effects and drug interactions limit their use in some patients. Food and Drug Administration (FDA)-approved agents in the United States for oral therapies include terbinafine, itraconazole, and griseofulvin. The only topical product available up to recently was ciclopirox.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>This article will review efinaconazole and tavaborole, 2 new topical antifungal agents released in 2014.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0897190016630904","type":"journal-article","created":{"date-parts":[[2016,2,13]],"date-time":"2016-02-13T06:15:29Z","timestamp":1455344129000},"page":"245-255","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":23,"title":["Efinaconazole and Tavaborole"],"prefix":"10.1177","volume":"30","author":[{"given":"Mara","family":"Poulakos","sequence":"first","affiliation":[{"name":"Lloyd L. Gregory School of Pharmacy, Palm Beach Atlantic University, West Palm Beach, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasmin","family":"Grace","sequence":"additional","affiliation":[{"name":"Lloyd L. Gregory School of Pharmacy, Palm Beach Atlantic University, West Palm Beach, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jade D.","family":"Machin","sequence":"additional","affiliation":[{"name":"Lloyd L. Gregory School of Pharmacy, Palm Beach Atlantic University, West Palm Beach, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erin","family":"Dorval","sequence":"additional","affiliation":[{"name":"Lloyd L. Gregory School of Pharmacy, Palm Beach Atlantic University, West Palm Beach, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2016,7,8]]},"reference":[{"key":"bibr1-0897190016630904","unstructured":"Dresser LD. Chapter 98. Superficial Fungal Infections. In: DiPiro JT, Talbert RL, Yee GC, Matzke GR, Wells BG, Posey L. eds. Pharmacotherapy: A Pathophysiologic Approach, 9e. New York, NY: McGraw-Hill; 2014. Web site. http:\/\/accesspharmacy.mhmedical.com\/content.aspx?bookid=689&Sectionid=48811493. Accessed February 2, 2016."},{"key":"bibr2-0897190016630904","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(03)02117-0"},{"key":"bibr3-0897190016630904","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2003.05242.x"},{"key":"bibr4-0897190016630904","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-1097.2009.00672.x"},{"key":"bibr5-0897190016630904","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2011.02.038"},{"key":"bibr6-0897190016630904","unstructured":"Efinaconazole [monograph]. In: Lexicomp [online database]. Hudson, OH: Lexi-Comp. Web site. http:\/\/online.lexi.com\/lco\/action\/doc\/retrieve\/docid\/patch_f\/5189944. Accessed February 2, 2016."},{"key":"bibr7-0897190016630904","unstructured":"Jublia (efinaconazole) [product monograph]. Laval, Quebec, Canada: Valeant Canada LP; October 2013."},{"key":"bibr8-0897190016630904","unstructured":"Jublia (efinaconazole) [prescribing information]. Bridgewater, NJ: Valeant Pharmaceuticals North America; March 2015. Accessed February 2, 2016."},{"key":"bibr9-0897190016630904","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-014-0276-7"},{"key":"bibr10-0897190016630904","unstructured":"Anacor Pharmaceutical Inc. Tavaborole KERYDIN\u2122 (tavaborole): US prescribing information. 2014. Web site. http:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/label\/2014\/204427s000lbl.pdf. Accessed February 2, 2016."},{"issue":"7","key":"bibr11-0897190016630904","first-page":"10","volume":"7","author":"Del Rosso JQ","year":"2014","journal-title":"J Clin Aesthet Dermatol"},{"key":"bibr12-0897190016630904","doi-asserted-by":"publisher","DOI":"10.1016\/j.yrtph.2014.07.012"},{"key":"bibr13-0897190016630904","unstructured":"Tavaborole [monograph]. In Micromedex Drugdex [online database]. Web site. http:\/\/www.micromedexsolutions.com\/micromedex2\/librarian\/ND_T\/evidencexpert\/ND_PR\/evidencexpert\/CS\/F14947\/ND_AppProduct\/evidencexpert\/. 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Ciclopirox [package insert]. 2010. Web site. http:\/\/dailymed.nlm.nih.gov\/dailymed\/archives\/fdaDrugInfo.cfm?archiveid=36161. 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