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Aminophylline was administered and resulted in immediate and sustained symptom resolution. Ticagrelor has been associated with dyspnea and bradyarrhythmias, both attributed to increased adenosine exposure. Ticagrelor inhibits reuptake of intracellular adenosine. Adenosine antagonists aminophylline and theophylline have been utilized to reverse the effects of adenosine and may relieve adenosine-mediated adverse effects induced by ticagrelor therapy. Aminophylline may be considered for reversal of dyspnea and bradyarrhythmia associated with ticagrelor therapy through alterations in adenosine exposure.<\/jats:p>","DOI":"10.1177\/0897190016680978","type":"journal-article","created":{"date-parts":[[2016,12,5]],"date-time":"2016-12-05T20:45:27Z","timestamp":1480970727000},"page":"112-114","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":15,"title":["Successful Reversal of Bradycardia and Dyspnea With Aminophylline After Ticagrelor Load"],"prefix":"10.1177","volume":"31","author":[{"given":"Sarah A.","family":"Minner","sequence":"first","affiliation":[{"name":"Hospital Pharmacy Services, The University of Chicago Medicine, Chicago, IL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pamela","family":"Simone","sequence":"additional","affiliation":[{"name":"Hospital Pharmacy Services, The University of Chicago Medicine, Chicago, IL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benjamin B.","family":"Chung","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The University of Chicago Medicine, Chicago, IL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atman P.","family":"Shah","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The University of Chicago Medicine, Chicago, IL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2016,12,5]]},"reference":[{"key":"bibr1-0897190016680978","unstructured":"Brilinta (ticagrelor) [package insert]. 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