{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T01:55:42Z","timestamp":1777859742892,"version":"3.51.4"},"reference-count":28,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2017,3,15]],"date-time":"2017-03-15T00:00:00Z","timestamp":1489536000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pharmacy Practice"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:p>\n                    We aim to describe our experience with the four-factor prothrombin complex concentrates (4F-PCC) Kcentra\n                    <jats:sup>\u00ae<\/jats:sup>\n                    at differing doses in patients with liver cirrhosis requiring emergent hemostasis in the setting of major or life-threatening bleeding. An automated query of patients who received Kcentra between January 2014 and March 2016 was performed. Patients who had clinically significant bleeding and received Kcentra for treatment of coagulopathy of chronic liver disease (CCLD) were included in the study. Baseline patient demographics, administration indication, pertinent laboratory values, and other reversal therapies were collected. Four patients met inclusion for analysis. One patient presented with hemopericardium, cardiac tamponade, and shock, and 3 patients presented with intracranial hemorrhage. Each patient experienced an improvement in international normalized ratio (INR) and at least a period of clinical hemostasis after Kcentra administration without complications referable to Kcentra. Kcentra may be a safe, rapid, and effective treatment option for hemorrhagic emergencies associated with CCLD. Further research is needed to determine the ideal monitoring and dosing regimen for use in CCLD.\n                  <\/jats:p>","DOI":"10.1177\/0897190017696952","type":"journal-article","created":{"date-parts":[[2017,3,15]],"date-time":"2017-03-15T04:22:18Z","timestamp":1489551738000},"page":"120-125","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":11,"title":["The Use of Kcentra\n                    <sup>\u00ae<\/sup>\n                    in the Reversal of Coagulopathy of Chronic Liver Disease"],"prefix":"10.1177","volume":"31","author":[{"given":"Deepika","family":"Pereira","sequence":"first","affiliation":[{"name":"Department of Pharmacy, Northwestern Memorial Hospital, Chicago, IL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric","family":"Liotta","sequence":"additional","affiliation":[{"name":"Section of Neurocritical Care, Northwestern Memorial Hospital, Chicago, IL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmed A.","family":"Mahmoud","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Northwestern Memorial Hospital, Chicago, IL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2017,3,15]]},"reference":[{"key":"bibr1-0897190017696952","doi-asserted-by":"publisher","DOI":"10.1111\/trf.12707"},{"key":"bibr2-0897190017696952","doi-asserted-by":"publisher","DOI":"10.1097\/00042737-200301000-00004"},{"key":"bibr3-0897190017696952","doi-asserted-by":"crossref","unstructured":"Shah NL, Intagliata NM, Northup PG, Procoagulant therapeutics in liver disease: a critique and clinical rationale. Nat Rev Gastroenterol Hepatol. 2014;11(11):675\u2013682. Web site. Web site: http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25023035","DOI":"10.1038\/nrgastro.2014.121"},{"key":"bibr4-0897190017696952","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1011170"},{"key":"bibr5-0897190017696952","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2004.04973.x"},{"key":"bibr6-0897190017696952","doi-asserted-by":"crossref","unstructured":"Barton CA. Treatment of coagulopathy related to hepatic insufficiency. Crit Care Med [Internet]. 2016;44(10). Web site. http:\/\/journals.lww.com\/ccmjournal\/Fulltext\/2016\/10000\/Treatment_of_Coagulopathy_Related_to_Hepatic.16.aspx. Accessed November 20, 2016.","DOI":"10.1097\/CCM.0000000000001998"},{"key":"bibr7-0897190017696952","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccc.2012.04.006"},{"key":"bibr8-0897190017696952","doi-asserted-by":"crossref","unstructured":"Hsia CC, Chin-Yee IH, McAlister VC. Use of recombinant activated factor VII in patients without hemophilia: a meta-analysis of randomized control trials. Ann Surg. 2008;248(1):61\u201368. Web site: www.ncbi.nlm.nih.gov\/pubmed\/18580208","DOI":"10.1097\/SLA.0b013e318176c4ec"},{"key":"bibr9-0897190017696952","volume-title":"Product Information: KCENTRA(R) Intravenous Injection Lyophilized Powder for Solution, Prothrombin Complex Concentrate Human Intravenous Injection Lyophilized Powder for Solution","author":"Thromboembolic V","year":"2013"},{"key":"bibr10-0897190017696952","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.113.002283"},{"key":"bibr11-0897190017696952","doi-asserted-by":"publisher","DOI":"10.1186\/cc9311"},{"issue":"3","key":"bibr12-0897190017696952","first-page":"3","volume":"28","author":"Lusher JM","year":"1991","journal-title":"Semin Hematol"},{"key":"bibr13-0897190017696952","unstructured":"Hoffman. Chapter 155 - Hematologic Manifestations of Liver Disease [Internet]. Sixth Edit. Hematology: Basic Principles and Practice 6th ed. Elsevier Inc. 2012:2167\u20132172.e1 p. http:\/\/dx.doi.org\/10.1016\/B978-1-4377-2928-3.00155-6. Accessed November 20, 2016."},{"key":"bibr14-0897190017696952","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccc.2005.03.002"},{"key":"bibr15-0897190017696952","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2008.03674.x"},{"key":"bibr16-0897190017696952","doi-asserted-by":"publisher","DOI":"10.1016\/j.tmrv.2014.03.002"},{"key":"bibr17-0897190017696952","doi-asserted-by":"publisher","DOI":"10.1309\/NQXHUG7HND78LFFK"},{"key":"bibr18-0897190017696952","doi-asserted-by":"publisher","DOI":"10.1186\/cc8205"},{"key":"bibr19-0897190017696952","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2003.07467.x"},{"key":"bibr20-0897190017696952","doi-asserted-by":"crossref","unstructured":"Franchini M, Montagnana M, Targher G, The use of recombinant factor VIIa in liver diseases. Blood Coagul Fibrinolysis [Internet]. 2008;19(5):341\u2013348. Web site: http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/18600080.","DOI":"10.1097\/MBC.0b013e32830496a7"},{"key":"bibr21-0897190017696952","doi-asserted-by":"crossref","unstructured":"Mart\u00ed-Carvajal AJ, Karakitsiou DE, Salanti G. Human recombinant activated factor VII for upper gastrointestinal bleeding in patients with liver diseases. Cochrane Database Syst Rev [Internet]. 2012;3:CD004887. Web site: http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22419301.","DOI":"10.1002\/14651858.CD004887.pub3"},{"key":"bibr22-0897190017696952","doi-asserted-by":"crossref","unstructured":"Amarapurkar PD, Amarapurkar DN. Management of coagulopathy in patients with decompensated liver cirrhosis. Int J Hepatol\n                      [Internet]\n                      . 2011;2011:695470. http:\/\/www.pubmedcentral.nih.gov\/articlerender.fcgi?artid=3227517&tool=pmcentrez&rendertype=abstract. Accessed November 20, 2016.","DOI":"10.4061\/2011\/695470"},{"key":"bibr23-0897190017696952","doi-asserted-by":"crossref","unstructured":"Parand A, Honar N, Aflaki K, Management of bleeding in post-liver disease, surgery and biopsy in patients with high uncorrected international normalized ratio with prothrombin complex concentrate: an Iranian experience. Iran Red Crescent Med J [Internet]. 2013;15(12):e12260. http:\/\/www.pubmedcentral.nih.gov\/articlerender.fcgi?artid=3955503&tool=pmcentrez&rendertype=abstract. Accessed November 20, 2016.","DOI":"10.5812\/ircmj.12260"},{"key":"bibr24-0897190017696952","doi-asserted-by":"publisher","DOI":"10.1002\/phar.1827"},{"key":"bibr25-0897190017696952","doi-asserted-by":"crossref","unstructured":"de Oliveira Manoel AL, Goffi A, Zampieri FG, The critical care management of spontaneous intracranial hemorrhage: a contemporary review. Crit Care [Internet]. 2016;20(1):272. http:\/\/dx.doi.org\/10.1186\/s13054-016-1432-0. 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