{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T01:53:42Z","timestamp":1777859622791,"version":"3.51.4"},"reference-count":23,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2017,6,14]],"date-time":"2017-06-14T00:00:00Z","timestamp":1497398400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pharmacy Practice"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Vitamin K antagonists (VKAs) have been used for decades to prevent thromboembolic events, but can be burdensome to patients based on numerous factors impacting anticoagulation control. Low-dose vitamin K supplementation has been theorized to improve anticoagulation control in patients on VKAs that may be vitamin K deficient. The objective of this literature review is to propose criteria for implementing low-dose vitamin K supplementation in patients on VKAs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Literature review:<\/jats:title>\n                    <jats:p>The CHEST 2012 antithrombotic guidelines recommended against routine use of vitamin K supplementation in patients on VKAs. An observational study and three randomized controlled trials pertaining to this recommendation were evaluated. A literature review was also performed on other studies looking at the impact of low-dose vitamin K supplementation on anticoagulation control through a search in PubMed and the Cochrane Database of Systematic Reviews. One retrospective and two prospective studies were reviewed. Six of the seven studies demonstrated a non-statistically significant trend in data supporting improvement in anticoagulation control with low-dose vitamin K supplementation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>While many of the studies did not achieve significant results, the majority demonstrated a trend in support of the improvement of anticoagulation control with low-dose vitamin K supplementation in patients on VKAs.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0897190017711518","type":"journal-article","created":{"date-parts":[[2017,6,14]],"date-time":"2017-06-14T05:01:45Z","timestamp":1497416505000},"page":"208-215","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Proposed Criteria for the Use of Low-Dose Vitamin K Supplementation in Patients Using Vitamin K Antagonists: A Literature Review of a Clinical Controversy"],"prefix":"10.1177","volume":"31","author":[{"given":"Christy E.","family":"Evans","sequence":"first","affiliation":[{"name":"Scott & White Medical Center \u2013 Temple, Temple, TX, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katerine E.","family":"Getchell","sequence":"additional","affiliation":[{"name":"Department of Veterans Affairs, Central Texas Veterans Health Care System, Temple, TX, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Delaney R.","family":"Ivy","sequence":"additional","affiliation":[{"name":"Scott & White Medical Center \u2013 Temple, Temple, TX, USA"},{"name":"Department of Pharmacy Practice, Texas A&M University Irma Lerma Rangel College of Pharmacy, Temple, TX, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2017,6,14]]},"reference":[{"key":"bibr1-0897190017711518","doi-asserted-by":"publisher","DOI":"10.1378\/chest.11-2292"},{"key":"bibr2-0897190017711518","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-200544120-00003"},{"key":"bibr3-0897190017711518","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-04-1525"},{"issue":"5","key":"bibr4-0897190017711518","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1160\/TH04-06-0346","volume":"92","author":"Kurnik D","year":"2004","journal-title":"Thromb Haemost"},{"key":"bibr5-0897190017711518","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-09-049262"},{"key":"bibr6-0897190017711518","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2007.02715.x"},{"key":"bibr7-0897190017711518","doi-asserted-by":"publisher","DOI":"10.1592\/phco.2005.25.12.1746"},{"key":"bibr8-0897190017711518","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2010.08108.x"},{"key":"bibr9-0897190017711518","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2010.035162"},{"key":"bibr10-0897190017711518","doi-asserted-by":"publisher","DOI":"10.1007\/s11239-007-0014-z"},{"key":"bibr11-0897190017711518","doi-asserted-by":"publisher","DOI":"10.1160\/TH10-04-0257"},{"issue":"2","key":"bibr12-0897190017711518","doi-asserted-by":"crossref","first-page":"e125S","DOI":"10.1378\/chest.11-2295","volume":"141","author":"Holbrook A","year":"2012","journal-title":"CHEST"},{"key":"bibr13-0897190017711518","doi-asserted-by":"publisher","DOI":"10.1378\/chest.10-2738"},{"key":"bibr14-0897190017711518","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2015.03.017"},{"key":"bibr15-0897190017711518","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.167.3.239"},{"key":"bibr16-0897190017711518","doi-asserted-by":"publisher","DOI":"10.1185\/030079905X75050"},{"key":"bibr17-0897190017711518","doi-asserted-by":"publisher","DOI":"10.1111\/jth.12969"},{"key":"bibr18-0897190017711518","unstructured":"Xarelto\u00ae [package insert]. Titusville, NJ: Janssen Pharmaceuticals, Inc. 2015."},{"key":"bibr19-0897190017711518","unstructured":"Pradaxa\u00ae [package insert]. Ridgefield, CT: Boehringer Ingelheim Pharmaceuticals, Inc. 2015."},{"key":"bibr20-0897190017711518","unstructured":"Eliquis\u00ae [package insert]. Princeton, NJ and New York NY: Bristol-Myers Squibb Company and Pfizer Inc. 2015."},{"key":"bibr21-0897190017711518","unstructured":"Savaysa\u00ae [package insert]. Parsippany, NJ: Daiichi Sankyo Co., LTD. 2015."},{"issue":"5","key":"bibr22-0897190017711518","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1160\/TH04-12-0773","volume":"93","author":"Sconce E","year":"2005","journal-title":"Thromb Haemost"},{"key":"bibr23-0897190017711518","unstructured":"Institute of Medicine (US) Panel on Micronutrients. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington (DC): National Academies Press (US); 2001. 5, Vitamin K. Available from: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK222299\/. Accessed June 11, 2016."}],"container-title":["Journal of Pharmacy Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0897190017711518","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0897190017711518","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0897190017711518","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T00:34:33Z","timestamp":1777509273000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0897190017711518"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6,14]]},"references-count":23,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2018,4]]}},"alternative-id":["10.1177\/0897190017711518"],"URL":"https:\/\/doi.org\/10.1177\/0897190017711518","relation":{},"ISSN":["0897-1900","1531-1937"],"issn-type":[{"value":"0897-1900","type":"print"},{"value":"1531-1937","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,6,14]]}}}