{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T01:53:49Z","timestamp":1777859629614,"version":"3.51.4"},"reference-count":15,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2017,10,5]],"date-time":"2017-10-05T00:00:00Z","timestamp":1507161600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pharmacy Practice"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:p>Garcinia cambogia is a Southeast Asian fruit becoming increasingly popular as a weight management supplement. Hydroxycitric acid (HCA) is the primary active ingredient which demonstrates serotonergic- and muscarinic-enhancing properties via inhibition of selective serotonin reuptake and acetylcholinesterase. We report a young adult female with no history of bipolar disorder who developed mania and psychosis approximately 1 week following initiation of G cambogia and the Cleanse and Detox\u2122 dietary supplement manufactured by Apex Vitality Health. She presented with a predominantly expansive mood, psychomotor agitation, disorganized and pressured speech, flight of ideas, grandiosity, delusions, and auditory hallucinations. Following discontinuation of G cambogia and the initiation of lithium and quetiapine, the patient experienced rapid and progressive mood stabilization and was discharged after 8 days. Seven previous case reports associating (hypo)mania and\/or psychosis with G cambogia consumption have been published. The chronology of mania and\/or psychosis onset may appear between 1 and 8 weeks following initiation of G cambogia. Psychiatric symptoms have resolved with G cambogia discontinuation in some instances and may not require chronic pharmacotherapy. Our report should encourage further research and case reports regarding this adverse event and the reconciliation of complete herbal supplement use at clinic visits and hospital admissions.<\/jats:p>","DOI":"10.1177\/0897190017734728","type":"journal-article","created":{"date-parts":[[2017,10,5]],"date-time":"2017-10-05T21:33:50Z","timestamp":1507239230000},"page":"99-102","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":16,"title":["Possible\n                    <i>Garcinia cambogia<\/i>\n                    -Induced Mania With Psychosis: A Case Report"],"prefix":"10.1177","volume":"32","author":[{"given":"David C.","family":"Nguyen","sequence":"first","affiliation":[{"name":"Department of Pharmacy Practice, College of Health Professions & Biomedical Sciences, The University of Montana, Missoula, MT, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tysen K.","family":"Timmer","sequence":"additional","affiliation":[{"name":"The University of Washington School of Medicine, Seattle, WA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Blair C.","family":"Davison","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Providence St Patrick Hospital, Missoula, MT, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ian R.","family":"McGrane","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Practice, College of Health Professions & Biomedical Sciences, The University of Montana, Missoula, MT, USA"},{"name":"Department of Pharmacy, Providence St Patrick Hospital, Missoula, MT, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2017,10,5]]},"reference":[{"key":"bibr1-0897190017734728","doi-asserted-by":"publisher","DOI":"10.1016\/j.fitote.2015.02.012"},{"issue":"5","key":"bibr2-0897190017734728","first-page":"835","volume":"29","author":"Klein Junior LC","year":"2010","journal-title":"Lat Am J Pharm"},{"key":"bibr3-0897190017734728","doi-asserted-by":"publisher","DOI":"10.1007\/s13181-014-0390-7"},{"key":"bibr4-0897190017734728","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.1981.154"},{"key":"bibr5-0897190017734728","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2004.12.029"},{"key":"bibr6-0897190017734728","doi-asserted-by":"publisher","DOI":"10.1177\/0004867413493522"},{"key":"bibr7-0897190017734728","doi-asserted-by":"publisher","DOI":"10.1177\/0004867416634869"},{"key":"bibr8-0897190017734728","doi-asserted-by":"publisher","DOI":"10.1177\/0004867416667827"},{"issue":"2","key":"bibr9-0897190017734728","first-page":"1","volume":"18","author":"Hendrickson BP","year":"2016","journal-title":"Prim Care Companion CNS Disord"},{"issue":"1","key":"bibr10-0897190017734728","volume":"18","author":"Wong MK","year":"2016","journal-title":"Prim Care Companion CNS Disord"},{"key":"bibr11-0897190017734728","doi-asserted-by":"publisher","DOI":"10.1006\/abio.2001.5046"},{"issue":"6","key":"bibr12-0897190017734728","volume":"13","author":"Patel A","year":"2011","journal-title":"Prim Care Companion CNS Disord"},{"issue":"7","key":"bibr13-0897190017734728","first-page":"40","volume":"6","author":"Potash MN","year":"2009","journal-title":"Psychiatry (Edgmont)"},{"key":"bibr14-0897190017734728","doi-asserted-by":"publisher","DOI":"10.1176\/appi.psy.42.6.525"},{"key":"bibr15-0897190017734728","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.201601020"}],"container-title":["Journal of Pharmacy Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0897190017734728","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0897190017734728","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0897190017734728","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T00:34:40Z","timestamp":1777509280000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0897190017734728"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,10,5]]},"references-count":15,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,2]]}},"alternative-id":["10.1177\/0897190017734728"],"URL":"https:\/\/doi.org\/10.1177\/0897190017734728","relation":{},"ISSN":["0897-1900","1531-1937"],"issn-type":[{"value":"0897-1900","type":"print"},{"value":"1531-1937","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,10,5]]}}}