{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T01:53:56Z","timestamp":1777859636950,"version":"3.51.4"},"reference-count":45,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2017,11,28]],"date-time":"2017-11-28T00:00:00Z","timestamp":1511827200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pharmacy Practice"],"published-print":{"date-parts":[[2019,4]]},"abstract":"<jats:p>Sexual dysfunction is a bothersome side effect of several medications, though it has not yet been reported with the use of ledipasvir\/sofosbuvir for the treatment of hepatitis C. However, sexual dysfunction is a potentially unrecognized side effect of ledipasvir\/sofosbuvir that could result in nonadherence and treatment failure. We report a case of a 42-year-old man with a sudden onset of sexual dysfunction with the initiation of ledipasvir\/sofosbuvir for the treatment of hepatitis C. The patient had no prior history or risk factors for the development of sexual dysfunction. His symptoms resolved upon discontinuation of ledipasvir\/sofosbuvir after a successful 12-week course. Clinicians should be aware that sexual dysfunction is a possible side effect of ledipasvir\/sofosbuvir and educate patients appropriately. Adherence should be emphasized as the risks of untreated hepatitis C virus far outweigh transient sexual dysfunction.<\/jats:p>","DOI":"10.1177\/0897190017744421","type":"journal-article","created":{"date-parts":[[2017,11,28]],"date-time":"2017-11-28T22:10:52Z","timestamp":1511907052000},"page":"231-235","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Sexual Dysfunction in a Patient Taking Ledipasvir\/Sofosbuvir for the Treatment of Hepatitis C: A Case Report"],"prefix":"10.1177","volume":"32","author":[{"given":"Destin U.","family":"Lenz","sequence":"first","affiliation":[{"name":"Belmont University College of Pharmacy, Nashville, TN, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Effie L.","family":"Crutcher","sequence":"additional","affiliation":[{"name":"Belmont University College of Pharmacy, Nashville, TN, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisa M.","family":"Greene","sequence":"additional","affiliation":[{"name":"Belmont University College of Pharmacy, Nashville, TN, USA"},{"name":"Siloam Family Health Center, Nashville, TN, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2017,11,28]]},"reference":[{"key":"bibr1-0897190017744421","unstructured":"Viral Hepatitis. 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