{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T19:04:51Z","timestamp":1790881491330,"version":"4.1.0"},"reference-count":20,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2018,1,8]],"date-time":"2018-01-08T00:00:00Z","timestamp":1515369600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"crossref","award":["UL1TR001117"],"award-info":[{"award-number":["UL1TR001117"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pharmacy Practice"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>De-escalation to a beta-lactam improves outcomes for patients with a methicillin-susceptible Staphylococcus aureus bloodstream infection (BSI). Whether a similar strategy is appropriate for enterococcal species is less clear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To determine whether definitive antibiotic selection affects outcomes for patients with an ampicillin-susceptible enterococcal BSI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>This retrospective cohort study included patients over 18 years of age receiving definitive therapy with vancomycin or a beta-lactam for one or more blood cultures positive for Enterococcus spp. isolates between 2007 and 2014. Survival differences were examined using a Kaplan-Meier curve with log-rank test.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>One-hundred eighty-six patients received definitive therapy with either vancomycin (n = 45, 24.2%) or a beta-lactam (n = 141, 75.8%). The primary outcome, 30-day all-cause mortality, was not different between groups (6.7% vs 7.1%; P = .992). A post hoc analysis of all-cause mortality 1 year after the index BSI was significantly higher in the vancomycin group (51% vs 33%; P = .032). In a Cox proportional hazards regression model, definitive vancomycin was associated with an increased risk of all-cause mortality at 1 year (hazard ratio [HR]: 2.39; 95% confidence interval [CI]: 1.41-4.04).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>For patients with an ampicillin-susceptible enterococcal BSI, definitive therapy with vancomycin or a beta-lactam was not independently associated with a difference in 30-day all-cause mortality. Whether definitive vancomycin is associated with poor long-term outcomes warrants further exploration.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0897190017751208","type":"journal-article","created":{"date-parts":[[2018,1,8]],"date-time":"2018-01-08T21:44:47Z","timestamp":1515447887000},"page":"375-381","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["Effectiveness of Vancomycin or Beta-Lactam Therapy in Ampicillin-Susceptible\n                    <i>Enterococcus<\/i>\n                    spp. Bloodstream Infections"],"prefix":"10.1177","volume":"32","author":[{"given":"Jesse M.","family":"Fletcher","sequence":"first","affiliation":[{"name":"Department of Pharmacy, Duke University Hospital, Durham, NC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shawn J.","family":"Kram","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Duke University Hospital, Durham, NC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina B.","family":"Sarubbi","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Duke University Hospital, Durham, NC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deverick J.","family":"Anderson","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine, Duke Infection Control Outreach Network, Duke University Hospital, Durham, NC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bridgette L.","family":"Kram","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Duke University Hospital, Durham, NC, 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