{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T01:54:34Z","timestamp":1777859674863,"version":"3.51.4"},"reference-count":26,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2019,4,16]],"date-time":"2019-04-16T00:00:00Z","timestamp":1555372800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pharmacy Practice"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Antistaphylococcal \u03b2-lactams antibiotics are the preferred treatment for methicillin-sensitive Staphylococcus aureus (MSSA) infections. Patient-reported \u03b2-lactam allergies may complicate antibiotic decision-making and delay optimal therapy, with potential implications on patient outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To determine the impact of reported \u03b2-lactam allergies on the receipt of optimal therapy and outcomes for MSSA bloodstream infections (BSI).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Retrospective, matched cohort of MSSA BSI patients with and without a reported \u03b2-lactam allergy. The primary end point was receipt of optimal therapy, defined as an antistaphylococcal \u03b2-lactam.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Two hundred twelve patients were included: 53 with reported \u03b2-lactam allergy and 159 without \u03b2-lactam allergy. Commonly reported \u03b2-lactam allergies were 26 (49%) immune-mediated reaction and 8 (15%) intolerance, with 19 (36%) having no documented reaction. Optimal antibiotics were given to 135 patients without a \u03b2-lactam allergy and 37 patients with a reported \u03b2-lactam allergy (85% vs 70%, P = .015). Among reported \u03b2-lactam allergy patients, those without a documented reaction were less likely to receive optimal therapy (47% vs 79 %, P = .042). Reported \u03b2-lactam allergy was not associated with clinical response ( P = .61) or MSSA-related mortality ( P = .83). When adjusting for immunosuppression, variables independently associated with optimal therapy were \u03b2-lactam allergy (adjusted odds ratio [adjOR], 0.3; 95% confidence interval [CI], 0.1-0.6) and infectious diseases consultation (adjOR, 6.1; 95%CI, 2.7-13.9). Optimal antibiotic use was associated with decreased all-cause 90-day mortality (adjOR, 0.23; 95%CI, 0.09-0.54).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Patients with reported \u03b2-lactam allergies, particularly those without a documented reaction, were less likely to receive optimal antibiotics for MSSA BSI. Patient outcomes may be improved with enhanced quality of allergy history and routine infectious disease consultation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0897190019841737","type":"journal-article","created":{"date-parts":[[2019,4,17]],"date-time":"2019-04-17T01:29:38Z","timestamp":1555464578000},"page":"809-814","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Impact of Reported \u03b2-Lactam Allergy on Management of Methicillin-Sensitive\n                    <i>Staphylococcus aureus<\/i>\n                    Bloodstream Infections"],"prefix":"10.1177","volume":"33","author":[{"given":"Michael P.","family":"Veve","sequence":"first","affiliation":[{"name":"Henry Ford Hospital, Detroit, MI, USA"},{"name":"Department of Pharmacy Practice, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, MI, USA."},{"name":"The author is now with the Department of Clinical Pharmacy and Translational Science, University of Tennessee Health Science Center, Knoxville, TN, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Spenser E.","family":"January","sequence":"additional","affiliation":[{"name":"Henry Ford Hospital, Detroit, MI, USA"},{"name":"The author is now with Barnes-Jewish Hospital, St Louis, MO, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachel M.","family":"Kenney","sequence":"additional","affiliation":[{"name":"Henry Ford Hospital, Detroit, MI, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edward M.","family":"Zoratti","sequence":"additional","affiliation":[{"name":"Henry Ford Hospital, Detroit, MI, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcus J.","family":"Zervos","sequence":"additional","affiliation":[{"name":"Henry Ford Hospital, Detroit, MI, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan L.","family":"Davis","sequence":"additional","affiliation":[{"name":"Henry Ford Hospital, Detroit, MI, USA"},{"name":"Department of Pharmacy Practice, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, MI, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2019,4,16]]},"reference":[{"key":"bibr1-0897190019841737","doi-asserted-by":"publisher","DOI":"10.1086\/345476"},{"issue":"19","key":"bibr2-0897190019841737","doi-asserted-by":"crossref","first-page":"2229","DOI":"10.1001\/archinte.162.19.2229","volume":"162","author":"Blot SI","year":"2002","journal-title":"Arch Intern Med"},{"issue":"7","key":"bibr3-0897190019841737","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1016\/j.ajic.2015.01.031","volume":"43","author":"Thampi N","year":"2015","journal-title":"Am J Infect Control"},{"key":"bibr4-0897190019841737","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.05022-11"},{"issue":"3","key":"bibr5-0897190019841737","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1086\/647264","volume":"17","author":"Mylotte JM","year":"1996","journal-title":"Infect Control Hosp Epidemiol"},{"key":"bibr6-0897190019841737","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00101-07"},{"key":"bibr7-0897190019841737","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2334-11-279"},{"key":"bibr8-0897190019841737","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/civ394"},{"key":"bibr9-0897190019841737","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0159406"},{"key":"bibr10-0897190019841737","doi-asserted-by":"crossref","unstructured":"Turner NA, Moehring R, Sarubbi C, et al. 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