{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T01:54:42Z","timestamp":1777859682468,"version":"3.51.4"},"reference-count":9,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2019,6,27]],"date-time":"2019-06-27T00:00:00Z","timestamp":1561593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pharmacy Practice"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>We describe a case of morphine toxicity presumably caused by accumulation of its active metabolite morphine-6-glucuronide (M6G) secondary to reduced clearance by peritoneal dialysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We present the relevant history and laboratory data and review pertinent literature regarding the use of opioids in renal failure.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>A 76-year-old African-American female received one dose of morphine sulfate and developed signs and symptoms of morphine toxicity for 2 days, even after multiple peritoneal dialysis sessions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Because of reduced renal clearance of morphine and its metabolites in patients requiring peritoneal dialysis, morphine should be avoided as an analgesic option in this population due to increased risk of morphine toxicity.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0897190019853992","type":"journal-article","created":{"date-parts":[[2019,6,28]],"date-time":"2019-06-28T00:16:43Z","timestamp":1561681003000},"page":"903-906","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Morphine Use in Renal Failure: A Case Report of Single-Dose Morphine Toxicity in a Patient Requiring Peritoneal Dialysis"],"prefix":"10.1177","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4854-8329","authenticated-orcid":false,"given":"Nicole A.","family":"Slater","sequence":"first","affiliation":[{"name":"Department of Pharmacy Practice, Harrison School of Pharmacy, Auburn University, AL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthony M.","family":"Todd","sequence":"additional","affiliation":[{"name":"Department of Family Medicine, University of South Alabama College of Medicine, AL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marirose C.","family":"Trimmier","sequence":"additional","affiliation":[{"name":"Department of Family Medicine, University of South Alabama College of Medicine, AL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristina C.","family":"Campbell","sequence":"additional","affiliation":[{"name":"Department of Family Medicine, University of South Alabama College of Medicine, AL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2019,6,27]]},"reference":[{"key":"bibr1-0897190019853992","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/14.4.903"},{"key":"bibr2-0897190019853992","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpainsymman.2004.02.021"},{"key":"bibr3-0897190019853992","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.1981.154"},{"key":"bibr4-0897190019853992","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-200005000-00038"},{"key":"bibr5-0897190019853992","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.09910917"},{"key":"bibr6-0897190019853992","unstructured":"Coalition for Supportive Care of Kidney Patients: Treating pain in advanced CKD and dialysis patients: Clinical algorithm and preferred medications, 2016. Accessed Aug 21, 2018. http:\/\/www.kidneysupportivecare.org\/Files\/TreatingPaininLateCKD11-2016.aspx"},{"key":"bibr7-0897190019853992","doi-asserted-by":"publisher","DOI":"10.1089\/jpm.2007.0142"},{"key":"bibr8-0897190019853992","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2006050477"},{"key":"bibr9-0897190019853992","doi-asserted-by":"publisher","DOI":"10.1191\/026921601669626431"}],"container-title":["Journal of Pharmacy Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0897190019853992","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0897190019853992","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0897190019853992","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T00:35:33Z","timestamp":1777509333000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0897190019853992"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6,27]]},"references-count":9,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2020,12]]}},"alternative-id":["10.1177\/0897190019853992"],"URL":"https:\/\/doi.org\/10.1177\/0897190019853992","relation":{},"ISSN":["0897-1900","1531-1937"],"issn-type":[{"value":"0897-1900","type":"print"},{"value":"1531-1937","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,6,27]]}}}