{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T01:54:53Z","timestamp":1777859693644,"version":"3.51.4"},"reference-count":24,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2019,10,30]],"date-time":"2019-10-30T00:00:00Z","timestamp":1572393600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pharmacy Practice"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Intravenous (IV) iron sucrose can be used for iron deficiency anemia (IDA), but little information exists on total dose infusion (TDI) of this drug. At a tertiary hospital, an iron sucrose TDI protocol was implemented with staff pharmacists aiding physicians in appropriate dosing.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>We sought to define the safety and efficacy of this protocol in adults \u226518 years old with IDA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We conducted a retrospective chart review of patients who received iron sucrose TDI. Inclusion criteria included patients \u226518 years old who were hospitalized and received iron sucrose in doses \u2265300 mg. We reviewed the medical record for adverse reactions to any TDI of iron sucrose as well as pre-TDI and post-TDI hemoglobin (Hgb) levels to assess efficacy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>A total of 238 patients received iron sucrose TDI for IDA during the study period. One hundred ninety-three (81%) patients were female, and the mean age in our cohort was 60.6 years. Mean pre-TDI Hgb was 8.76 g\/dL. The mean total dose of iron sucrose in the total cohort was 680 mg (range: 300-2500 mg). Adverse effects attributable to iron sucrose were reported in 15 patients, with nausea being the most common effect (7\/238, 2.9%). When matching patients\u2019 preadmission and postadmission records, a Hgb increase of 2.1 g\/L was found ( P &lt; .001). No increase in liver function tests was found in any patient.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>A pharmacist-assisted iron sucrose TDI protocol for patients with IDA successfully increased serum Hgb and was well tolerated. Anaphylaxis was not reported.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0897190019885239","type":"journal-article","created":{"date-parts":[[2019,10,30]],"date-time":"2019-10-30T23:56:51Z","timestamp":1572479811000},"page":"573-576","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Retrospective Safety Evaluation of a Pharmacist-Assisted Total Dose Iron Sucrose Protocol in Hospital Inpatients With Iron Deficiency Anemia"],"prefix":"10.1177","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8668-9966","authenticated-orcid":false,"given":"Geoffrey","family":"Wall","sequence":"first","affiliation":[{"name":"College of Pharmacy and Health Sciences, Drake University, Des Moines, IA, USA"},{"name":"Internal Medicine Residency, Iowa Methodist Medical Center, Des Moines, IA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vedica","family":"Sharma","sequence":"additional","affiliation":[{"name":"Internal Medicine Residency, Iowa Methodist Medical Center, Des Moines, IA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew J.","family":"Taylor","sequence":"additional","affiliation":[{"name":"Internal Medicine Residency, Iowa Methodist Medical Center, Des Moines, IA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Schneider","sequence":"additional","affiliation":[{"name":"Internal Medicine Residency, Iowa Methodist Medical Center, Des Moines, IA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristi","family":"Adams","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Iowa Methodist Medical Center, Des Moines, IA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lindy","family":"Gasperi","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Iowa Methodist Medical Center, Des Moines, IA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joshua C.","family":"Lukenbill","sequence":"additional","affiliation":[{"name":"Staff Hematologist, Medical Oncology and Hematology Associates, Des Moines, IA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2019,10,30]]},"reference":[{"key":"bibr1-0897190019885239","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1401038"},{"key":"bibr2-0897190019885239","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.f4822"},{"key":"bibr3-0897190019885239","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-6686.2009.00127.x"},{"key":"bibr4-0897190019885239","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2015.15572"},{"key":"bibr5-0897190019885239","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-1755.2005.00758.x"},{"key":"bibr6-0897190019885239","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2015.189"},{"key":"bibr7-0897190019885239","volume-title":"Venofer Product Information","year":"2019"},{"key":"bibr8-0897190019885239","doi-asserted-by":"publisher","DOI":"10.1111\/apt.14043"},{"key":"bibr9-0897190019885239","doi-asserted-by":"publisher","DOI":"10.2146\/ajhp070222"},{"key":"bibr10-0897190019885239","volume-title":"ImFed Product Information","year":"2004"},{"key":"bibr11-0897190019885239","unstructured":"Ravel R. 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